"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 5212075 | Compositions and methods for introducing effectors to pathogens and cells Compositions and methods for the inhibition and prevention of pathogenic infection and neoplastic disease are provided. The compositions include hybrid molecules having a binding moiety and an effector moiety joined by a linker region. When administered t... | 05/18/1993 |
| 5210022 | Method test media and chromogenic compounds for identifying and differentiating general coliforms and Escherichia coli bacteria A chromogenic ଲ-galactosidase substrate producing an insoluble precipitate of a first color when reacted upon by ଲ-galactosidase and a chromogenic ଲ-glucuronidase substrate producing an insoluble precipitate of a second, contrasting colo... | 05/11/1993 |
| 5198339 | Method for detection of gram-negative bacterial lipopolysaccharides in biological fluids The invention relates to a method of detecting gram-negative bacterial endotoxin using antibody capture combined with amoebocyte lysate chromogenic detection. The method is highly sensitive and rapid and may be used for detection of specific endotoxin. In... | 03/30/1993 |
| 5164298 | Verocytotoxin receptor assay This invention relates to the identification of verocytotoxin receptors of the formula: X--O--Y(R) (I) wherein Y is sphingosine, hydroxylated sphinogosine or saturated sphingosine, wherein X is selected from said... | 11/17/1992 |
| 5137812 | Colony blotting method and device A method and article for the identification of colonies of microbes involves the use of a reconstitutable dry culture medium plate in combination with a transfer membrane. Microbe-specific antigen can be extracted from the surface of the growth medium of ... | 08/11/1992 |
| 5126244 | Determination of antigens A method for the liberation of polysaccharide antigens from bacteria or fungi in biological probes or in grown cultures of these probes is described. In the majority of cases such a liberation is necessary in order that subsequently the polysaccharide ant... | 06/30/1992 |
| 5075228 | Recombinant clones of Chlamydia trachomatis lipopolysaccharide Disclosed is a clone and the process for cloning genes encoding the genus-specific lipopolysaccharide antigen of chlamydia. The clone is a hybrid lipopolysaccharide molecule composed of both chlamydia and E. coli components.... | 12/24/1991 |
| 4906567 | Non-immunochemical binding of lipopolysaccharides and sandwich assays therefor Sandwich assays for detecting and identifying lipopolysaccharides of gram negative bacteria utilizing immobilized lipopolysaccharide binding proteins and labelled detection reagents are provided. The active supports are also useful in removing LPS from bi... | 03/06/1990 |
| 4898815 | Novel synthetic peptide, process for its preparation and medicaments containing it The invention provides a synthetic peptide which reproduces at least 5 of the 11 amino acids common to the γ chain of sub-unit A of cholera toxin and the γ chain of LT toxin of Escherichia coli. It is preferably constituted by a pentadecapeptide which c... | 02/06/1990 |
| 4784943 | Ice nucleation immunoassay A novel method for carrying out immunoassays is described. The method involves use of a biological ice nucleating agent as a label. In particular, the method involves use of ice nucleating bacteria, or ice nucleating components derived therefrom, as a lab... | 11/15/1988 |
| 4722891 | Methods and compositions for detection of Legionnaires' disease Recombinant E. coli clones which cell surface-express Legionella pneumophila antigens, a method for utilizing these clones for the detection of Legionella antibodies in a clinical sample, and a method for isolation of mono-specific anti-Legionella antibod... | 02/02/1988 |
| 4693968 | Agent for quantitative determination of microorganisms An agent for quantitative determination of microorganisms, which comprises (a) an antibody prepared from a strain of the same species as the species of microorganisms to be determined, (b) an insolubilized cell component of a strain which can sufficiently bind ... | 09/15/1987 |
| 4683196 | Method and materials for the identification of lipopolysaccharide producing microorganisms The subject invention provides a means for the immunological detection of an entire class of microorganisms in clinical samples. The detection is accomplished by reaction of the clinical sample iwth a class-specific immunological reagent. This reagent is ... | 07/28/1987 |
| 4677080 | Rapid particle agglutination test for enterotoxigenic bacteria A rapid technique is disclosed for the identification of enteric bacteria which elaborate cholera-related heat-labile enterotoxin antigens which have the ability to cause diarrheal disease in man or animals. The invention includes a sensitized carrier par... | 06/30/1987 |
| 4677055 | Immunological detection of bacterial pathogens with antibody-containing magnetic gel A process for the immunobacteriological detection of pathogenic germs possessing specific antigenic determinants, and a kit for carrying out the process, with the aid of a magnetic gel to which are coupled anti-specific antigenic determinant antibodies, c... | 06/30/1987 |
| 4657849 | Compositions and methods useful for uropathogenic bacterial identification or diagnosis and inhibition of adherence of uropathogenic bacteria to cells having a structural element similar to that of the active principle of the invention Compositions and methods useful for identification or diagnostic use, or inhibition of adherence of uropathogenic bacteria to cells, all in connection with uropathogenic bacterial infections, containing as an active constituent the structural element, pre... | 04/14/1987 |
| 4617265 | Colony blot assay for enterotoxigenic bacteria A plate of suitable nutrient medium and agar is inoculated with bacteria from a biological sample. Bacterial colonies are cultured on the plate and are then overlaid with a soft agar layer containing bacterial lysing agents. A removable sheet with bound f... | 10/14/1986 |
| 4592994 | Method for the determination of biochemical data Microorganisms and unicellular organisms in a sample are identified or determined by exposing the sample to an adsorbent having a specific binding power for the entity to be determined to bind the entity to the adsorbent, separating unbound sample, exposi... | 06/03/1986 |
| 4492761 | Complement assay method A method of determining (1) the activity of complement, (2) the bacteriolytic activity of serum, or (3) the titer of antibody in a sample which comprises: (a) incubating complement-sensitive microorganisms containing an assayable intracellular component w... | 01/08/1985 |
| 4439356 | Unsymmetrical fluorescein derivatives Unsymmetrically substituted 6-hydroxy-3H-xanthen-3-ones for use as fluorescers or quenchers, particularly conjugated to provide reagents in competitive protein binding assays. Substituents are aliphatic groups bonded to an annular carbon atom through carb... | 03/27/1984 |
| 4397959 | Forced precipitation method for preparing antigen/antibody particles Process for the preparation of test reagents comprising antigens or antibodies adsorbed on a surface, for example, the surface of synthetic or natural polymer particles in which the test material to be adsorbed is dissolved in a solvent in contact with th... | 08/09/1983 |
| 4374925 | Macromolecular environment control in specific receptor assays Method and compositions are provided for performing protein binding assays involving a homologous pair consisting of ligand and receptor for the ligand. The method employs a label conjugated to a member of said homologous pair and a uniformly dispersed di... | 02/22/1983 |
| 4288539 | Bacterial or bacterial antibody assay Automated tests to evaluate the antibody titer of a sample by incubating a test sample, bacteria, and complement, and detecting bacterial growth in the incubated mixture, and to identify bacteria and its titer in a sample by incubating a test sample, bact... | 09/08/1981 |
| 4281061 | Double antibody for enhanced sensitivity in immunoassay Method and compositions are provided for performing homogeneous immunoassays. The method involves having a signal producing system, which provides a detectable signal, which system includes a macromolecular member. The determination of the analyte, which ... | 07/28/1981 |
| 4275149 | Macromolecular environment control in specific receptor assays Method and compositions are provided for performing protein binding assays involving a homologous pair consisting of ligand and receptor for the ligand. The method employs a label conjugated to a member of said homologous pair and a uniformly dispersed di... | 06/23/1981 |
| 4223005 | Antibody coated bacteria Process for identification and enumeration of B and T lymphocytes in an unseparated peripheral body sample comprises contacting the sample with two morphologically distinguishable bacteria, each of which is coated with an antibody specific to an antigen o... | 09/16/1980 |
| 4166767 | Insolubilized antibody An insolubilized antibody suitable for an enzyme immuno assay or radio immuno assay, which has characteristic infrared absorptions at around 1,040 cm-1, 1,540 cm-1 and 1,640 cm-1 and is prepared by chemically binding an an... | 09/04/1979 |
| 4133639 | Test article including a covalently attached diagnostic reagent and method A body suitable for use in the quantitative detection of an unknown quantity of a biologically derived sample suitably by radioimmunoassay, fluorometric detection, or by spectrophotometry. The body includes a handle attached to a nonparticulate, nonswella... | 01/09/1979 |
| 4104126 | Non-isotopic substrate assay employing bacteriolysis products Substrates such as haptens and antigens, and those for receptor proteins and native circulating binding proteins are assayed by determining bacteriolysis products occasioned by bacteriophage infection of host cells, in a modification of the "chemically mo... | 08/01/1978 |