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| Number | Title | Issue Date |
| 7803567 | Methods and compositions for detecting in a sample contacted with fixative The present invention provides methods and compositions for detecting a Trichomonas antigen in a fixed sample and for diagnosing Trichomonas infection by detecting a Trichomonas antigen in a fixed sample. ... | 09/28/2010 |
| 7455985 | Detection and quantification of intracellular pathogens The present invention provides methods and compositions for detecting bacteria of the Chlamydiaceae family in a biological sample. Methods include, for example, contacting a biological sample with an antibody that specifically binds to a chlamydial antigen displayed... | 11/25/2008 |
| 7354721 | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same Methods of determining whether a sample includes one or more analytes, particularly proteinaceous analytes, of interest are provided. In the subject methods, an array of binding agents, where each binding agent includes an epitope binding domain of an antibody, is c... | 04/08/2008 |
| 7312071 | Effective monitoring system for anthrax smallpox, or other pathogens A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devic... | 12/25/2007 |
| 7253275 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising o... | 08/07/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7169550 | Diffraction-based diagnostic devices A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive mater... | 01/30/2007 |
| 7157603 | Method for the separation of oligomeric N-substituted (meth)acrylamide compounds and conjugates thereof which are reversibly thermally precipitating The method of separating reversibly thermally precipitable oligomeric N-substituted (meth)acrylamides and conjugates thereof from aqueous solution includes thermally precipitating the oligomeric N-substituted (meth)acrylamides and the conjugates thereof from an aque... | 01/02/2007 |
| 7153651 | Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the s... | 12/26/2006 |
| 7122314 | Methods for detecting vancomycin-resistant microorganisms and compositions therefor A method for detecting the presence of a vancomycin-resistant microorganism in a biological sample using a single chimeric probe in a cycling probe reaction. ... | 10/17/2006 |
| 7105171 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising o... | 09/12/2006 |
| 7070791 | Detection of antibodies against pgp3 antigen in patient sera by enzyme-linked immunoassay A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis, serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy on clinical samples in an ELISA format. ... | 07/04/2006 |
| 7018807 | Method and medium for detecting vancomycin-resistant A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium for vancomycin-resistant Enterococci and includes specifi... | 03/28/2006 |
| 7008797 | Recovery of liquids from absorbent packaging materials The present invention describes a method for recovery of aqueous samples or components thereof from polymer packaging materials, wherein the spilled aqueous sample has been absorbed by the packaging material to form a liquid swollen absorbent gel. The method compris... | 03/07/2006 |
| 7005270 | Compositions and methods for detecting Methods for the specific and highly sensitive detection of Treponema pallidum infection comprising the use of specific antigenic proteins and peptides unique to Treponema pallidum are provided. In particular, detection assays based recognition of acidi... | 02/28/2006 |
| 6955908 | Organism associated with nongonococcal urethritis The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument for collecting and detecting an SPR infection, and methods for treating... | 10/18/2005 |
| 6919187 | Compounds and methods for treatment and diagnosis of chlamydial infection Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceu... | 07/19/2005 |
| 6913929 | Sexual fidelity and sex crime verification A series of unique biochemical tests are combined to enable unskilled law enforcement and private investigation personnel to rapidly perform sex crime investigations on skin swipes and body fluid residues deposited on specific articles of clothing. The invention als... | 07/05/2005 |
| 6858439 | Compositions and methods for separation of moieties on chips The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in... | 02/22/2005 |
| 6838552 | Diagnosis and management of infection caused by Chlamydia The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stag... | 01/04/2005 |
| 6815173 | Method for detecting syphilis using synthetic antigents An antigen composition and method for the detection of antibodies to Treponema pallidum and the diagnosis of syphilis are described. The antigen composition contains synthetic cardiolipin and synthetic lecithin. The antigen composition may additionally contai... | 11/09/2004 |
| 6706490 | Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the CB10 peptide of mammalian type II collagen, or an antibody-binding f... | 03/16/2004 |
| 6699678 | Chlamydia trachomatis specific peptides and their use in diagnostic assays Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis (C. trachomatis) immunodominant major outer membrane protein (MOMP). The peptides or mixtures of peptides are characterized... | 03/02/2004 |
| 6676949 | Two-step immunization procedure against Chlamydia infection A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a... | 01/13/2004 |
| 6660275 | Chlamydia antigens and corresponding DNA fragments and uses thereof The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequenc... | 12/09/2003 |
| 6607730 | Chlamydia antigens and corresponding DNA fragments and uses thereof In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, ... | 08/19/2003 |
| 6565856 | Compounds and methods for treatment and diagnosis of chlamydial infection Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharm... | 05/20/2003 |
| 6562586 | In vitro model for HIV and other viral diseases An in vitro model system for viral infection is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherin the supported tissue block is cultured in a medium whose surface is congruent with th... | 05/13/2003 |
| 6479248 | Process and agent for detecting antibodies against Treponema pallidum A method and agent for antibodies against Treponema pallidum are provided. The method involves gene-amplifying and cloning a selection of recombinant antigens. The selection of recombinant antigens consists of 17 kD antigen, 47 kD antigen and TmpA. The an... | 11/12/2002 |
| 6355449 | Method and medium for detecting vancomycin-resistant enterococcus A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium for vancomycin-resistant Enterococci and includes specific n... | 03/12/2002 |
| 6344335 | Liposome immunoassay A liposome or microsphere containing guaiac or other reagent is used in an immunoassay to detect an antigen or antibody. The guaiac or other reagent reacts with hemoglobin or other blood constituent to produce color indicating a positive result.... | 02/05/2002 |
| 6300140 | Rapid test employing an adhesive slide A slide having a portion thereof provided with transparent adhesive which adheres to a test sample. The slide and adhesive may be transparent. Specific types of infection and particularly fungal infections can be detected in the test sample using immunote... | 10/09/2001 |
| 6277965 | CysS The invention provides cysS polypeptides and DNA (RNA) encoding cysS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing cysS polypeptides to screen for antibacterial compounds.... | 08/21/2001 |
| 6258532 | Methods for in vitro susceptibility testing of chlamydia Methods for determining the susceptibility of intracellular pathogens, particularly Chlamydia, to single or combination of test agents are described. The methods can be used for in vitro or in vivo evaluation of agents that can be used as therapeutic agen... | 07/10/2001 |
| 6207647 | RatA The invention provides ratA polypeptides and DNA (RNA) encoding ratA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ratA polypeptides to screen for antibacterial compounds.... | 03/27/2001 |
| 6165478 | DNA encoding Chlamydia pneumoniae antigenic polypeptide Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding said antigenic polypeptides, or DNAs complementary thereto; recombinant... | 12/26/2000 |
| 6159703 | Assays Enhanced extraction and assay of solubilized lipopolysaccharide antigens from bacteria such as Chlamydia by the use of a buffer containing an anionic polysaccharide, especially heparin, and surface active agent, especially CHAPS or CHAPSO.... | 12/12/2000 |
| 6146839 | Chlamydia pneumoniae antigens, method for production of the antigens, method and reagents for measurement of anti-Chlamydia pneumoniae antibodies using the antigens The present invention relates to a Chlamydia pneumoniae antigen comprising protein derived from the outer membrane of Chlamydia pneumoniae, a method for producing a Chlamydia pneumoniae antigen which comprises solubilizing the cytosol and the cytoplasmic ... | 11/14/2000 |
| 6096519 | Chlamydia trachomatis serotype D proteins A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; ... | 08/01/2000 |
| 6030799 | Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthetic major outer membrane protein polypeptides as substitute antigens Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recog... | 02/29/2000 |
