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| Number | Title | Issue Date |
| 8071326 | Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The metho... | 12/06/2011 |
| 8039217 | Proteomic interaction and genomic action determinations in the presence of associated redox state conditions Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease includ... | 10/18/2011 |
| 7906295 | Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The metho... | 03/15/2011 |
| 7799535 | Methods for identifying factors that control the folding of amyloid proteins of diverse origin The present invention provides a yeast cell based system for determining factors that control the folding of amyloid proteins of diverse origins. Further the present invention provides methods of using such a system to screen for reagents that affect amyloid formati... | 09/21/2010 |
| 7794962 | High-throughput screening of expressed DNA libraries in filamentous fungi The invention provides a method for the expression of exogenous DNA libraries in filamentous fungi. The fungi are capable of processing intron-containing eukaryotic genes, and also can carry out post-translational processing steps such as glyclosylation and protein ... | 09/14/2010 |
| 7759079 | Methods of diagnosing inflammatory bowel disease The present invention provides methods for diagnosing the presence or severity of inflammatory bowel disease (IBD) in an individual and methods for stratifying IBD by determining the level of one or more IBD markers in a sample from the individual and calculating an... | 07/20/2010 |
| 7745158 | Detection of secreted aspartyl proteases from species Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorgani... | 06/29/2010 |
| 7622271 | Identification of aging genes through large-scale analysis High throughput methods for screening genetic variants that are phenotypically distinguishable are provided. Methods for identifying “long-lived” genetic variants among a set of variants are also provided. Methods for identifying pharmaceutical compounds that ca... | 11/24/2009 |
| 7618793 | Identifying agents for decreasing cellular toxicity associated with huntingin polypeptide Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene assoc... | 11/17/2009 |
| 7611854 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 11/03/2009 |
| 7566547 | Gene 763 of phytopathogenic fungus and use thereof for identifying fungicidal compounds The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of... | 07/28/2009 |
| 7429449 | Potassium channel mutants of the yeast and their use for screening eukaryotic potassium channels The invention relates to processes for identifying inhibitors and activators of eukaryotic potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous potassium channels TRK1, TRK2 and TOK1 are not expressed functionally, but which expr... | 09/30/2008 |
| 7413876 | Expression of G protein coupled receptors in yeast Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protein-coupled receptor and a second heterologous DNA sequence which codes for a mammalian G protein α subunit (mammalian Gα). The first an... | 08/19/2008 |
| 7361260 | Methods, articles and kits for labeling polymer gels The invention provides methods, apparatus and kits for integrally labeling polymeric gels, such as polyacrylamide and agarose gels, with indicia that can serve, inter alia, unambiguously to identify the individual gel, using polymeric film labeled with detectable in... | 04/22/2008 |
| 7361498 | Yeast cells expressing modified G proteins and methods of use therefor The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coup... | 04/22/2008 |
| 7358043 | Proteomic interaction and genomic action determinations in the presence of associated redox state conditions Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease includ... | 04/15/2008 |
| 7354726 | Screening method The present invention intends to provide a screening of agonist/antagonist and the like. Specifically, the invention provides a method of screening a compound or its salt that alters the binding property between a novel G protein-coupled receptor protein or its salt... | 04/08/2008 |
| 7351573 | BGL3 beta-glucosidase and nucleic acids encoding the same The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant ... | 04/01/2008 |
| 7349158 | Diffraction grating-based encoded micro-particles for multiplexed experiments Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected... | 03/25/2008 |
| 7335515 | (1→3)-β-D-glucan binding domain protein, measuring method using the substance and assay kit A (1→3)-β-D-glucan binding protein, a fluorescence-labeled (1→3)-β-D-glucan binding domain protein, a (1→3)-β-D-glucan measuring agent comprising the same, a method for measuring (1→3)-β-D-glucan using the same, and a (1→3)-β-D-glucan assay kit compri... | 02/26/2008 |
| 7335505 | Materials and methods relating to protein aggregation in neurodegenerative disease The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor protein is associated with a disease state in which the precursor protein ... | 02/26/2008 |
| 7323299 | Methods for in vivo diversification of single genes Methods and compositions are provided for the efficient in vivo diversification of gene-products in filamentous fungi, starting from (but not limited to) two or more copies of a single gene constituent. The diversification involve use of the Repeat-Induced Point mut... | 01/29/2008 |
| 7319009 | Methods and compositions for identifying receptor effectors The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screenin... | 01/15/2008 |
| 7314712 | Systems for in vivo site-directed mutagenesis using oligonucleotides This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The methods employ integrative recombinant oligonucleotides (IROs). Specific ... | 01/01/2008 |
| 7291454 | Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines t... | 11/06/2007 |
| 7291477 | Method and device for detection A method and kit for detecting Trichomonas vaginalis infection in a human subject are disclosed. In the method, a body-fluid sample such as a vaginal swab sample or urine is obtained from the subject and contacted with an antibody specific against a Tricho... | 11/06/2007 |
| 7285403 | Xylose-fermenting recombinant yeast strains Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as methods of fermenting xylose to obtain ethanol using the recombinant... | 10/23/2007 |
| 7273747 | Cell having amplified signal transduction pathway responses and uses therefor The invention provides recombinant cells that have been engineered such that ligand stimulation of a receptor expressed by the cells leads to amplified signal transduction responses. In one embodiment, the receptor-expressing cells have been engineered to carry a he... | 09/25/2007 |
| 7270977 | Polypeptides for identifying fungicidally active compounds The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the polypeptides and nucleic acids for identifying modulators of the polypeptides, ... | 09/18/2007 |
| 7241905 | Dioxin analogues and methods and kits for searching out dioxins-decomposing organisms or enzymes or dioxin-decomposing enzyme genes The present invention provides a novel dioxin analogue for use in the search for organisms capable of degrading dioxin. The dioxin analogue is represented by the following chemical formula (1) or (2): ... | 07/10/2007 |
| 7232664 | Fermentation process using specific oxygen uptake rates as a process control Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invent... | 06/19/2007 |
| 7229762 | Proteomic screening for redox state dependent protein—protein interactions This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to identify NO-dependent interactions. The physiological relevance of these ... | 06/12/2007 |
| 7226735 | Xylose-fermenting recombinant yeast strains Disclosed are xylose-fermenting recombinant yeast strains comprising heterologous PsXYL1, Ps XYL2, and PsXYL3, as well as methods of fermenting xylose to obtain ethanol using the recombinant yeast strain. ... | 06/05/2007 |
| 7223533 | Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The ... | 05/29/2007 |
| 7208585 | Protein purification The present invention relates to a method of purifying a protein of interest from its fusion analog, comprising obtaining a protein solution comprising a protein of interest and its fusion analog; adjusting the pH and/or ionic strength of the protein solution with a... | 04/24/2007 |
| 7205104 | Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays A method for identifying or quantifying an organism by a detecting its nucleotide sequence among at least 4 other homologous sequences comprising amplifying nucleic acids from the organism to generate target nucleotide sequences to be detected; contacting the target... | 04/17/2007 |
| 7202356 | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast The regulatory sequences (i.e., promoter regions, introns and enhancers) associated with the Yarrowia lipolytica gene encoding fructose bis-phospate aldolase (FBA1) have been found to be particularly effective for the expression of heterologus genes in oleagi... | 04/10/2007 |
| 7202026 | Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array The present invention is related to an identification and/or quantification method of a large number of biological organisms groups at different levels (family, genus, species) or part of those (possibly present in a biological sample) by a detection of their nucleo... | 04/10/2007 |
| 7190522 | Chemical synthesis using diffraction grating-based encoded optical elements An optical identification element having a synthesized chemical attached thereto includes an optical substrate having at least one diffraction grating disposed therein, the grating having a resultant refractive variation at a grating location, said grating being emb... | 03/13/2007 |
| 7169550 | Diffraction-based diagnostic devices A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive mater... | 01/30/2007 |
