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| Number | Title | Issue Date |
| 4740457 | Method of diagnosis A method of identifying the presence or absence of an infected state in the living body by obtaining a biological fluid sample from a living body, adding to the sample a material known to bind with immune complex, adding to samples of the resulting materi... | 04/26/1988 |
| 4737455 | Analytical utilization of phagocyte cell lines The property of phagocyte cells to show chemiluminescence when activated by certain chemical or immunological agents is used for a qualitative and quantitative analysis of such agents in biological fluids. A variety of factors such as opsonizing anti-bodi... | 04/12/1988 |
| 4737453 | Sandwich immunoassay utilizing a separation specific binding substance Immunoassay system for determining the amount of a polyvalent ligand in a liquid test sample, and based on: (a) an insoluble phase to which is bound a separation specific binding substance which does not bind said ligand; (b) a capture specific binding substan... | 04/12/1988 |
| 4707442 | Hybrid cell line producing monoclonal antibody cytolytic to Trichomonas vaginalis Hybridomas secreting monoclonal antibody having specificity for and cytolytic against Trichomonas vaginalis are provided. The cytolytic monoclonal antibodies specific for T. vaginalis are useful in detecting the presence of T. vaginalis among a general po... | 11/17/1987 |
| 4703001 | Immunoassay for the detection of serum analytes using pH dependent chastropic acids The performance of immunoassays for the analysis of serum analytes can be significantly improved by the pretreatment of the sample. Analyte in serum samples is often complexed with serum antibody. Such analyte-antibody complexes can mask the analyte and i... | 10/27/1987 |
| 4695537 | Particles sensitized with detergent-treated antigen for agglutination immunoassay An agglutination immunoassay for antibody wherein antigen for sensitizing a solid particulate support is treated with detergent. The resultant antigen-sensitized support is resistant to self-agglutination.... | 09/22/1987 |
| 4670384 | Diagnostic reagent for swine trichinosis A hybrid cell formed by the fusion of a mouse spleen cell with a mouse myeloma cell secretes an IgM class antibody. The antibody is useful as a preparative reagent in the isolation of three proteins, molecular weights 45,000, 49,000 and 53,000, from the p... | 06/02/1987 |
| 4657850 | Serodiagnosis of heartworm infection An improvement in immunological methods for quantitative detection of Dirofilaria immitis antibodies in a fluid sample comprising a treatment of the sample with Toxocara canis-derived antigens.... | 04/14/1987 |
| 4656251 | Rapid separation of Dirofilaria immitis immune complexes A method for the rapid separation of Dirofilaria immitis immune complexes in a sample of blood or bodily fluid from an animal infected with Dirofilaria immitis preparatory to assaying for the presence of circulating parasite antigens of Dirofilaria immiti... | 04/07/1987 |
| 4612281 | Immunoassay for detecting immunoglobulins and test kit An immunoassay for detecting disease associated Ig, such as IgM associated with acute forms of Toxoplasma gondii infection. Wells of microtiter plates are first coated with an antibody against the Ig to be detected and the test sample, e.g. serum, is then... | 09/16/1986 |
| 4603106 | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) A mediator substance exhibiting inhibitory effect upon anabolic enzyme activity in mammals, is prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material t... | 07/29/1986 |
| 4596707 | Babesia parasite antigen useful in vaccine and diagnostic reagent Soluble antigen, specific for Babesia parasites, is isolated from growth media of Babesia-infected erythrocytes in cell culture and characterized, inter alia, by its ability to inhibit the capacity of specific Babesia serum antibodies to neutralize infect... | 06/24/1986 |
| 4548909 | Method of diagnosis A method of diagnosis using an attached material for binding to an immune complex, by treating the bound complex with a series of different reagents or mixtures thereof and detecting the presence or absence of reaction in each case, this method being base... | 10/22/1985 |
| 4540660 | Substrate for fluoroimmunoassay of biological fluids A substrate for fluoroimmunoassay is disclosed comprising a swellable, rehydratable polymeric protein-binding material forming a three-dimensional matrix; first particulate, light scattering centers distributed in the polymeric matrix capable of scatterin... | 09/10/1985 |
| 4530908 | Diagnosis and treatment of fluke infections with monoclonal antibodies Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded animal is provided which comprises the testing of body ser... | 07/23/1985 |
| 4517303 | Specific binding assays utilizing analyte-cytolysin conjugates A novel analyte-cytolysin conjugate and its use in a lipid vesicle mediated measurement process is described for a wide variety of analytes present at very low concentration. The method involves forming a reaction system consisting of analyte, analyte spe... | 05/14/1985 |
| 4480043 | Process for the preparation of toxoplasmas for the diagnosis of toxoplasmosis, and preparations thus obtained The invention relates to a process for obtaining preparations of toxoplasmas, improved for the diagnosis of toxoplasmosis by direct agglutination, said process comprising, in a first step, the inoculation in mice of a mixture of toxoplasmas and of sarcoma... | 10/30/1984 |
| 4459359 | Sensitive immunoassays of antigens or antibodies sequestered within immune complexes A process for determining the presence of an antigen or antibody in a sample wherein said antigen or antibody exists in the form of an immune complex which comprises: A. contacting the immune complex originating from the sample suspected of containing imm... | 07/10/1984 |
| 4446233 | Homogeneous immunoassay using covalent hybrid antibodies An immunoassay for analytes such as antigens or haptens, which utilizes covalent hybrid antibodies to modulate the activity of indicators. The hybrid antibody has binding sites for the analyte and the indicator. Final activity of the indicator is proporti... | 05/01/1984 |
| 4416866 | Diagnosis and treatment of fluke infections with monoclonal antibodies Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. Fluke infections are screened by determining presence of fluke antigens defined by antibodies produced by hybridomas ATCC HB-8086 and HB-8087. Chro... | 11/22/1983 |
| 4407943 | Immobilized antibody or antigen for immunoassay An antigen or antibody and an immunochemically neutral protein are immobilized in two stages on a microporous membrane coated with a protein such as zein or collagen. Immobilized antigen to Toxoplasma gondii is used in an immunoassay to detect the presenc... | 10/04/1983 |
| 4397959 | Forced precipitation method for preparing antigen/antibody particles Process for the preparation of test reagents comprising antigens or antibodies adsorbed on a surface, for example, the surface of synthetic or natural polymer particles in which the test material to be adsorbed is dissolved in a solvent in contact with th... | 08/09/1983 |
| 4361647 | Sandwich immunoassay and compositions for use therein An improved sandwich immunoassay for Toxoplasma gondii antigens associated with acute forms of Toxoplasma infection is disclosed. The assay employs either an F(ab')2 fragment of IgG which reacts specifically with such antigens or a monoclonal a... | 11/30/1982 |
| 4329331 | Diagnostic method for detection of systemic lupus erythematosus Systemic lupus erythematosus is diagnosed by contacting the blood serum of a patient with anaplasma antigen derived from a vertebrate infected by an organism of the genus Anaplasmataceae and thereafter contacting the antigen with an indicator for human im... | 05/11/1982 |
| 4322495 | Immunoassay An immunoassay for the detection of antibodies for canine heartworm (D. immitis) in the blood serum of dogs by immobilizing D. immitis microfilariae on a solid support which is then inoculated with a sample of the blood serum being tested, incubated and w... | 03/30/1982 |
| 4294817 | Method of fluoro immunoassay A new surface immunoassay method is performed with two test surfaces. The method is used where serum samples may contain both an antibody for which it is desirable to test, and also competing sera constituents which may be present in indeterminate amounts... | 10/13/1981 |
| 4246339 | Test device A test device for assaying liquid samples for the presence of a predetermined reagent is described. The device comprises telescoping top and bottom members defining a liquid reservoir therebetween, resilient means for biasing the members in the open posit... | 01/20/1981 |
| 4239746 | Complement fixation test employing reactants in a disposable package A ready-for-use rapid test package for carrying out serological investigations in which at least two of the following reactants: (1) patients serum; (2) erythrocytes; (3) amboceptors specific for the erythrocytes; (4) complement and (5) a reactant selected from the... | 12/16/1980 |
| 4200690 | Immunoassay with membrane immobilized antibody The presence of antigens is detected with a device having an antibody immunochemically reactive with the antigen bound to a first microporous membrane coated with an inert proteinaceous material and an antibody immunochemically non-reactive with the antig... | 04/29/1980 |
| 4158049 | Antigen fraction of Schistosoma mansoni eggs suitable for testing for schistosomiasis Schistosoma mansoni eggs are ground to liberate soluble egg antigens which are fractionated and purified by absorption, gel filtration and/or ion exchange chromatography, and then radioactively labelled with 125 I. A fraction, identified as MSA... | 06/12/1979 |
| 4150107 | Antigen from schistosomes and process for obtaining same The invention relates to a process for obtaining antigens from living adult schistosomes, wherein schistosomes are kept alive for 12 to 96 hours in a sterile physiologically tolerable salt solution, subsequently isolated and extracted with an aqueous medi... | 04/17/1979 |
| 4118349 | Process for the manufacture of polystyrene latex compounds The present invention relates to a process for the manufacture of protein or peptide polystyrene latex compounds useful as diagnostic agents, in which a protein or peptide is linked by means of an aromatic diazonium compound to a homo- or copolymer of sty... | 10/03/1978 |
| 4018884 | Fluorogenic materials and labeling techniques Compounds of the formula ##STR1## wherein R1 is lower alkyl or phenyl lower alkyl: R2 is phenyl or substituted phenyl; and R3 is substituted or unsubstituted phenyl, naphthyl or indolyl; Are fluorogenic reagents which... | 04/19/1977 |
| 3993743 | Method for diagnosis of Chagas' disease A process for diagnosing Chagas' disease in a living mammal susceptible to infection by Trypanosoma cruzi which comprises reacting in vitro an antibody-containing blood sample from said mammal in an immunoprecipitin test with an immunologically effective ... | 11/23/1976 |
| 3992516 | Direct fluorescent antibody composition and method for P. Pneumocystis carinii A Pneumocystis carinii antiserum conjugated with fluorescein isothiocyanate composition, its use being the detection of Pneumocystis carinii organisms and the method of making this composition using an enzyme purifying technique.... | 11/16/1976 |
| 3988115 | Diagnostic method for determining pathological condition by antigen-combining capacity of lymphocytes A method for determining in a patient the presence or absence of a pathological condition producing a specific immune response. The antigen associated with the pathological condition is labeled and added to a sample of the patient's lymphocytes and to a c... | 10/26/1976 |
| 3979509 | Opaque layer method for detecting biological particles A monomolecular layer of first biological particles is adsorbed on the surface of a substrate fabricated of virtually any nonreactive solid material, the coated substrate is then exposed to a solution suspected of containing second biological particles sp... | 09/07/1976 |
| 3963441 | Article with a lyophilized immunoreactive self-adhering coating An article for carrying out immunologic determinations. The article is provided with a lyophilized immunologic-reactive coating which is self-adhering to a carrier. The article is useful in diagnosing various diseases.... | 06/15/1976 |
| 3951748 | Sensitized matrix for detection of disease A specific sensitized matrix for diagnosing both infectious and non-infectious disease is disclosed comprised of an insoluble, inert, pliable and wettable matrix having a network of pores, and a protein polymer network immobilized in the network of pores ... | 04/20/1976 |
