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| Number | Title | Issue Date |
| 7368551 | DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 05/06/2008 |
| 7364864 | ANGE gene in atopy The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic acid sequences from two or more of th... | 04/29/2008 |
| 7364921 | Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a... | 04/29/2008 |
| 7364867 | Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The in... | 04/29/2008 |
| 7361275 | Use of derivatized nanoparticles to minimize growth of micro-organisms in hot filled drinks A method and article for removing a selected metal-ion from a solution. The method included providing a container for holding a liquid, the container having an internal surface having a metal-ion sequestering agent provided on at least a portion of the internal surf... | 04/22/2008 |
| 7361462 | Method for efficiently determining a DNA strand break The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors accomplished the present invention by providing a method for detectin... | 04/22/2008 |
| 7361336 | Methods of cancer therapy targeted against a cancer stem line Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer t... | 04/22/2008 |
| 7358060 | Method for monitoring and prognosis of disease course of gastrointestinal tumors The present invention provides a method for diagnosis, monitoring and prognosticating the disease course of gastrointestinal tumors, comprising determining the level of a cyclin dependent kinase inhibitor (CK1) in a sample and diagnosing the disease and/or recurrenc... | 04/15/2008 |
| 7359116 | Microscope turret mounted laser EPI-illumination port An optical injection system for use in conjunction with a microscope having a turret supporting an objective having an optical path is provided. The optical injection system includes a dichroic mirror disposed between the turret and the objective, along the optical ... | 04/15/2008 |
| 7358057 | QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells The present invention relates e.g., to QM-7 or QT-6 cells comprising a heterologous mutant nicotinic α7 acetylcholine receptor and/or a nucleic acid encoding it, or a fragment or variant thereof. In a preferred embodiment, the mutant nicotinic α7 acetylcholine rec... | 04/15/2008 |
| 7358059 | Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood (lymphocytes, monocytes, neutrophils and eosinophils). The single measurement ... | 04/15/2008 |
| 7357863 | Container for inhibiting microbial growth in liquid nutrients A fluid container and method for inhibiting the growth of microbes in liquid nutrient in a container, the container having an interior surface having a metal-ion sequestering agent and antimicrobial agent for inhibiting growth of microbes in the liquid nutrient.... | 04/15/2008 |
| 7354726 | Screening method The present invention intends to provide a screening of agonist/antagonist and the like. Specifically, the invention provides a method of screening a compound or its salt that alters the binding property between a novel G protein-coupled receptor protein or its salt... | 04/08/2008 |
| 7354721 | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same Methods of determining whether a sample includes one or more analytes, particularly proteinaceous analytes, of interest are provided. In the subject methods, an array of binding agents, where each binding agent includes an epitope binding domain of an antibody, is c... | 04/08/2008 |
| 7356416 | Method and system for automated inference creation of physico-chemical interaction knowledge from databases of co-occurrence data Methods and system for automated inference of physico-chemical interaction knowledge from databases of term co-occurrence data. The co-occurrence data includes co-occurrences between chemical or biological molecules or co-occurrences between chemical or biological m... | 04/08/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7354722 | Modulators of Smurf and BMP/TGFβ signaling pathways This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGFβ/activin pathway-specific Smads. The novel ligases have been named Smurf1 and Smurf2. They directly interact with Smads1 and 5 and Smad7, respectivel... | 04/08/2008 |
| 7355013 | PRO6017 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/08/2008 |
| 7351540 | Protein isolation and analysis Novel methods for the identification and/or sequencing of proteins are provided. These methods are particularly suited to screening antibody libraries and in preferred embodiments make use of mass spectrometry techniques for direct or indirect sequencing. ... | 04/01/2008 |
| 7348185 | Method and apparatus for capturing target substance A method for capturing a target substance in a sample, comprising the steps of preparing particles capable of capturing the target substance in a dispersed state in a fluid, aggregating the particles, and allowing the particles to capture the target substance in the... | 03/25/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7348155 | Method for identifying compounds for treating aging processes in the coronary circulatory system The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or breakdown of the extracellular matrix being influenced. ... | 03/25/2008 |
| 7348156 | 7B2 knockout transgenic animals as models of endocrine disease In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and ... | 03/25/2008 |
| 7349158 | Diffraction grating-based encoded micro-particles for multiplexed experiments Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected... | 03/25/2008 |
| 7344829 | Methods for detecting the efficacy of anticancer treatments Methods for determining the effectiveness of anticancer agents by determining and comparing growth factor receptor phosphorylation levels in samples obtained by non-invasive procedures before and after anticancer treatments are provided. The invention also provides ... | 03/18/2008 |
| 7344845 | Olfactory receptor for isovaleric acid and related malodorants and use thereof in assays for identification of blockers of malodor A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying potential anti-odorants which may be used in deodorants, air and carpe... | 03/18/2008 |
| 7344846 | Diagnostics and therapeutics for macular degeneration-related disorders The invention relates to methods for diagnosing and treating macular degeneration-related disorders. The invention also related to methods for identifying genes that cause macular degeneration-related disorders. ... | 03/18/2008 |
| 7341849 | Polynucleotides encoding SREB1 receptor This invention belongs to the genetic engineering field, and provides novel G protein-coupled receptor family proteins SREB1, SREB2 and SREB3 expressed in the central nervous system, genes coding for these proteins, screening methods using these proteins and so on. ... | 03/11/2008 |
| 7342108 | De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, ... | 03/11/2008 |
| 7338773 | Multiplexed assays of cell migration Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and/or microplates. ... | 03/04/2008 |
| 7338772 | G-protein coupled receptor ligands and methods The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which ... | 03/04/2008 |
| 7338769 | Methods for identifying agonists of cypin Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders. ... | 03/04/2008 |
| 7338767 | Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the ... | 03/04/2008 |
| 7338771 | Use of specific T2R taste receptors to identify compounds that block bitter taste Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with... | 03/04/2008 |
| 7335505 | Materials and methods relating to protein aggregation in neurodegenerative disease The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor protein is associated with a disease state in which the precursor protein ... | 02/26/2008 |
| 7335467 | Breast cancer antigens The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers f... | 02/26/2008 |
| 7332353 | Method for detecting analyte(s) using magnetic colloidal particles The invention concerns a method for detecting and/or quantifying at least an analyte in a liquid medium, characterized in that it consists in using magnetic colloidal particles functionalized at the surface with at least a ligand specific of the analyte to be detect... | 02/19/2008 |
| 7332291 | Methods of identifying modulators of ligand binding to ChemerinR polypeptides The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful fo... | 02/19/2008 |
| 7332292 | Constitutively translocating cell line The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modi... | 02/19/2008 |
| 7332295 | Multidimensional leukocyte differential analysis This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells, including the quantification of each subpopulation in terms of cells pe... | 02/19/2008 |
