Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 4376819 | Biological extracts and method for making same A p-nitrophenyl hydrolase contaminant present in Limulus coagulase sources interferes in, i.e., inhibits, coagulase-based assays for endotoxin. The contaminant inhibitor enzyme may be removed from coagulase by physical separation or by selective denaturat... | 03/15/1983 |
| 4375459 | Cytoreceptor assay Novel assays are provided employing specific ells having cytoreceptors for an analyte. The assay combines the specific cells, the sample, and a tagged analyte, normally radioactively tagged. After a sufficient time, the cells are separated, conveniently b... | 03/01/1983 |
| 4352751 | Species-linked diamine triacetic acids and their chelates Species-linked diamine triacetic acids of the formula ##STR1## wherein T is an organic species containing at least one amine, hydroxyl, or thiol functional group, L is the residue of at least one of those functional groups and R is a two or more atom... | 10/05/1982 |
| 4343734 | Protein diagnostic for atherosclerosis Compositions and processes featuring, in one aspect, a process of purifying a protein diagnostic for atherosclerosis comprising separating out of primate and human atherosclerotic tissue a Gla-containing protein of molecular weight of about 80,000.... | 08/10/1982 |
| 4334017 | Method for detecting cancer in mammalian tissue An improved method for assaying for cancer by detecting ଲ-linked galactose moieties associated with cells is disclosed wherein a label specific for such moieties is added to the cells and subsequently sensed.... | 06/08/1982 |
| 4322217 | Process for preparing Limulus lysate This invention relates to a process for treating Limulus Lysate having improved sensitivity to endotoxin, to lysate reagents utilizing such lysate, and to the use of such lysate reagents.... | 03/30/1982 |
| 4317877 | Process for detecting the presence of malignant and pre-malignant cells in humans Malignant and pre-malignant cells in humans are detected by contacting an antibody to oncofoetal deoxythymidine kinase with human cells and detecting the presence of cells containing oncofoetal deoxythymidine kinase antigen bound to the antibody.... | 03/02/1982 |
| 4314026 | Process for determining the complement-dependent cytotoxicity mediated by anti-HLA antibodies by means of ATP determination and device for ATP determination The present invention relates to a process for determining the complement-dependent cytotoxicity mediated by anti-HLA antibodies wherein the cytotoxicity is determined by measuring the loss of intracellular ATP after addition of complement to anti-HLA coa... | 02/02/1982 |
| 4297104 | Method of detecting or identifying virus antigens, erythrocyte or cell antigens or antibodies in a biological medium A method for detecting or identifying virus antigens or erythrocyte or cell antigens or antibodies in a biological medium. The reaction of analysis is conducted in a vessel the wall of which has a point of convegence or apex situated on the axis of symmet... | 10/27/1981 |
| 4287087 | Fixed-dried blood platelets Screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in human and animal blood plasma are effected using a reagent of blood platelets and snake venom having a positive platelet aggregating cofactor effect. The reagent and ... | 09/01/1981 |
| 4282315 | Preparation of enriched whole virus radioligand Obtaining a virus subpopulation, useful in qualitative and quantitative biological assay procedures, of enhanced sensitivity toward host cells for the virus by contacting a virus population with an inanimate substrate having moieties which mimic host cell... | 08/04/1981 |
| 4275150 | Radioenzymatic method for assaying normetanephrine Normetanephrine, an N-methylatable phenylethanolamine, is converted to its N-methylated, tritiated derivative, metanephrine, utilizing phenylethanolamine-N-methyltransferase as enzyme and tritiated S-adenosyl-L-methionine as methyl donor. The formed triti... | 06/23/1981 |
| 4275053 | Blood cell typing and compatibility test procedure A solid-phase blood typing procedure is described based upon either aggluation or immune lysis. In this invention, a monolayer of cells is irreversibly bound to a solid matrix, and thereafter a serum containing antibodies is brought into contact with the... | 06/23/1981 |
| 4263255 | Assay method and compounds The present invention provides an assay method for opioid activity comprising the steps of: (a) incubating together an opiate receptor material, a radio-iodinated structural analogue of leucine-enkephalin or methionine-enkephalin, and a liquid sample; (b)... | 04/21/1981 |
| 4257773 | Assay method and compounds The present invention provides an assay method for opioid activity comprising the steps of: (a) incubating together an opiate receptor material, a radio-iodinated structural analogue of leucine-enkephalin or methionine-enkephalin, and a liquid sample; (b)... | 03/24/1981 |
| 4251360 | Method and apparatus for the detection of a specific binding protein The invention provides a method for detecting and determining one component of the reaction between a specific binding protein, e.g., an antibody, and the corresponding bindable substance, e.g., an antigen, by utilizing the affinity of these components fo... | 02/17/1981 |
| 4224304 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody- or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample, irradiating the reaction mixture with li... | 09/23/1980 |
| 4208185 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody- or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample and irradiating the reaction mixture with... | 06/17/1980 |
| 4203724 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody-or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample and irradiating the reaction mixture with ... | 05/20/1980 |
| 4166106 | Immunologic determination method A method for determininng a reagent capable of immunologic reaction by direct or indirect test methods, wherein an antigen is contacted with the Fc fragment of an immune globulin prior to contacting it with an antibody having no specificity to said Fc fra... | 08/28/1979 |
| 4157383 | Tanned thrombocytes The invention provides tanned thrombocytes, a process for preparing them and a diagnostic agent containing them to make evident antibodies of thrombocytes.... | 06/05/1979 |
| 4144031 | Cell test for detecting human chorionic gonadotropin A diagnostic cell test and kit for detecting human chorionic gonadotropin as evidence of cancer. The subject's cells undergoing examination are contacted with artiserum specific to the beta-subunit of human chorionic gonadotropin, the antiserum having bee... | 03/13/1979 |
| 4142939 | Method of producing an R-type bacteriocin and its use in the detection of specific microorganisms A method of detecting a specific microorganism comprising contacting said microorganism with bacteriocins from a microorganism of a genus which is taxonomically unrelated to said specific organism. The result of such contact may be utilized to detect the ... | 03/06/1979 |
| 4118192 | Method and apparatus for the measurement of antigens and antibodies A method of the quantitative measurement of antigens and antibodies by reacting antibody- or antigen-sensitized insoluble carrier particles with a corresponding antigen or antibody or a mixture thereof in a sample and irradiating the reaction mixture with... | 10/03/1978 |
| 4096091 | Limulus lysate having improved capacity to precipitate in the presence of low endotoxin concentrations, and reconstituting solutions therefor A family of catalysts is disclosed for providing improved capacity for Limulus lysate solution to precipitate in the presence of extremely low concentrations of endotoxin. The catalyst family includes imidazole, manganese ions, Cleland's reagent, magnesiu... | 06/20/1978 |
| 4092116 | Method for binding antibodies to a surface such that they remain active In carrying out an immunological reaction or diagnostic test, an immunologically inert organic compound of sufficient quantity is added to an aqueous medium containing an immunologically reactive antigen. A substrate is then treated with the aqueous mediu... | 05/30/1978 |
| 4054646 | Method and apparatus for detection of antibodies and antigens Method and apparatus for the detection of antibodies and antigens based upon the effect that any arbitrary antigen will adsorb onto a substrate in a monomolecular layer only, but that a corresponding specific antibody for such arbitrary antigen will bond ... | 10/18/1977 |
| 4038029 | Limulus lysate turbidity test for pyrogens A sample of an aqueous liquid, e.g. an aqueous parenterally-administered drug, is tested for determining the amount of any endotoxin contained therein by admixing a sample of the liquid with lysate obtained by water lysing washed amebocyte cells from the ... | 07/26/1977 |
| 4002532 | Enzyme conjugates This invention relates to the provision of enzyme-macromolecule conjugates by conjugation with polyfunctional reagents in the presence of organic compounds which act as conditioners. Conjugation of enzymes with antibodies in the presence of conditioner yi... | 01/11/1977 |
| 3997657 | Dry slide reagent employed in immunofluorescent test for detection of human antinuclear factor A dry diagnostic reagent composed of specially prepared, fixed and stabilized fetal calf thymocytes on microscope slides ready for use in an immunofluorescent test for the detection of human anti-nuclear factor in human serum or plasma in the diagnosis of... | 12/14/1976 |
| 3966898 | Method and reagent for determining immunologic materials A method of qualitatively or quantitatively indicating immunoglobulin whose Fab-portion is bound to or is caused to bind to an antigen or a hapten or indicating the antigen or hapten which is bound to or caused to bind to the Fab-portion of the immunoglob... | 06/29/1976 |
