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| Number | Title | Issue Date |
| 7524640 | Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon. ... | 04/28/2009 |
| 7524639 | Assay for screening antipsychotic drugs A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal cell lines effect for it to predict the extrapyramidal symptoms that m... | 04/28/2009 |
| 7517661 | Methods of screening for ligands for FPRL2 The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of ... | 04/14/2009 |
| 7514229 | Methods for diagnosing and evaluating treatment of blood disorders Methods, systems and kits are provided for the clinical staging of blood disorders including myelodysplastic syndrome, myeloproliferative diseases and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or... | 04/07/2009 |
| 7510846 | Assay employing human or rat GAL-R2 galanin receptor The present invention is directed to a novel receptor for galanin which has been designated as galanin receptor 2. The invention encompasses both the receptor protein as well as nucleic acids encoding the protein. In addition, the present invention is directed to me... | 03/31/2009 |
| 7510847 | Kidney-specific urate transporter and gene thereof It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ... | 03/31/2009 |
| 7498141 | Assay system for GLP-2 receptor ligands Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP... | 03/03/2009 |
| 7491501 | Methods for identifying modulators of intracellular aggregate formation Methods and compositions for modulating the formation of intracellular aggregates are provided, in particular TRAF6 mediated intracellular aggregate formation. Additionally, methods and compositions for identifying modulators of intracellular aggregate formation are... | 02/17/2009 |
| 7491502 | In vivo flow cytometry system and method The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite t... | 02/17/2009 |
| 7491503 | Identification of ligands by selective amplification of cells transfected with receptors The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as in... | 02/17/2009 |
| 7485432 | Selective modulation of TLR-mediated biological activity Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the ... | 02/03/2009 |
| 7476511 | Method of detecting and analyzing paclitaxel-mimetic compounds A large part of cytostatics, among them paclitaxel (Taxol®) and other recently discovered substances that mimic its antitumour effects, have cellular microtubules as their target. The present invention is a high-efficiency homogeneous test based on the use of stabi... | 01/13/2009 |
| 7476512 | Methods of identifying dermal papilla cells Methods and compositions for identifying and isolating dermal papilla cells are described. DP cells can be identified based on corin expression. Isolated DP cells can be used, e.g., to modulate hair growth. ... | 01/13/2009 |
| 7465552 | Patched genes and uses related thereto Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinoma... | 12/16/2008 |
| 7455983 | Medium for growing human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of mouse embryonic fibroblast feeder cells to prevent them from differentiating. In the system described here, the r... | 11/25/2008 |
| 7449303 | Use of JAG2 expression in diagnosis of plasma cell disorders The present invention is based on the finding that plasma cell disorders such as Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance are characterized by an increase in the expression of JAG2. Accordingly, the present invention provides a method for d... | 11/11/2008 |
| 7445904 | Cysteine string protein and its role in neurodegenerative diseases The present invention relates to in vitro and in vivo assays for the identification of agents that are useful in the treatment of neurodegenerative diseases that are associated with defects in protein folding. The present further relates to in vitro and in vivo assa... | 11/04/2008 |
| 7445905 | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid... | 11/04/2008 |
| 7442516 | Antibody specific to central nervous system tau protein The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connec... | 10/28/2008 |
| 7439025 | Antibodies binding a gamma carboxyglutamic acid displaying epitope Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while not reacting with glutamic (Glu) residues in corresponding proteins and... | 10/21/2008 |
| 7439030 | Preparing membrane receptors from extracellular baculoviruses The present invention describes a method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors... | 10/21/2008 |
| 7439039 | Assays for novel serotonin transporter (SERT) blockers The serotonin transporter (SERT) is a target of various therapeutic agents used in the treatment of neurological and neurodegenerative disorders. The present invention provides novel forms of SERT that lacks high affinity recognition of specific serotonin reuptake i... | 10/21/2008 |
| 7435552 | Binding assays that use human T1R2 to identify potential taste modulators Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically ... | 10/14/2008 |
| 7431932 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 10/07/2008 |
| 7431928 | Identification of new CD8 epitopes from HIV-1 proteins The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 pro... | 10/07/2008 |
| 7429460 | Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid storage diseases, and use of the compounds for treating patients affecte... | 09/30/2008 |
| 7429459 | Methods for identifying a compound that inhibits the procession of amyloid-beta protein production in a mammalian cell expressing APP and overexpressing a G-protein coupled receptor in the cell A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-be... | 09/30/2008 |
| 7427488 | Purified and isolated platelet calcium channel nucleic acids and polypeptides and therapeutic and screening methods using same Isolated and purified platelet voltage dependent calcium channel (VDCC) α1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids, and recombinant proteins are also disclosed, along with meth... | 09/23/2008 |
| 7427478 | Beta-secretase enzyme compositions and methods Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recomb... | 09/23/2008 |
| 7427487 | Constitutively active CXCR3 G protein-coupled chemokine receptor and modulators thereof for the treatment of inflammatory disorders The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3 (CXCR3), and most particularly to mutated (non-endogenous) version of the ... | 09/23/2008 |
| 7427489 | Screening assay to identify modulators of the sleep/wake cycle Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also pr... | 09/23/2008 |
| 7427486 | Mullerian inhibiting substance levels and ovarian response Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and ser... | 09/23/2008 |
| 7425445 | Modulators that promote cell surface expression of odorant receptors The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptor... | 09/16/2008 |
| 7425420 | Identification of ligands by selective amplification of cells transfected with a 5HT2A receptor The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as in... | 09/16/2008 |
| 7422849 | Method for determining expression of a PI3 kinase gene This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptid... | 09/09/2008 |
| 7419779 | Modulators of angiogenesis The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids” which are involved in modulation of angiogenesis. The invention furth... | 09/02/2008 |
| 7413867 | Method for the identification of antagonists of a phenylthiocarbamide/bitter taste receptor The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block bitter taste transduction, or enhance bitter taste response. ... | 08/19/2008 |
| 7413864 | Treating cancer using a telomerase vaccine The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 08/19/2008 |
| 7407769 | Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms, and methods of correcting taste defects are also provided. ... | 08/05/2008 |
| 7407761 | Methods for assaying expression of novel galanin receptors The present invention is directed to methods for assaying a test compound's ability to alter the expression of novel receptor for galanin which has been designated as galanin receptor 2. The invention also encompasses both the receptor protein as well as nucleic aci... | 08/05/2008 |
