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| Number | Title | Issue Date |
| 6815174 | Thioredoxin-glutamate decarboxylase 65 fusion protein The present invention relates to a novel protein, a recombinant fusion hybrid, thioredoxin-human glutamate decarboxylase 65 and to a method of using such fusion protein in assaying anti-human glutamate decarboxylase antibodies for the diagnosis of insulin dependant ... | 11/09/2004 |
| 6815172 | Methods and compositions for opsonophagocytic assays Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneou... | 11/09/2004 |
| 6811787 | Over-expressing homologous antigen vaccine and a method of making the same This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering from disease caused by a pathogenic micro-organism. The vaccine is an ... | 11/02/2004 |
| 6808900 | Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof Cloning and expression of genes encoding C. parvum antigenic polypeptides are described as are antibodies that recognize epitopes on these polypeptides. The antigenic polypeptides and antibodies thereto can be used in therapeutic compositions for the preventi... | 10/26/2004 |
| 6808713 | Chlamydia antigens and corresponding DNA fragments and uses thereof The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The method involves nucleic acid immunization, including DNA immunization, and employs a vector conta... | 10/26/2004 |
| 6806065 | Rickettsia felis outer membrane protein The present invention is directed to isolated nucleic acid molecules encoding Rickettsia felis outer membrane proteins (R. felis omp). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for inc... | 10/19/2004 |
| 6805868 | Moraxella catarrhalis antigen, corresponding gene and uses thereof The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 10/19/2004 |
| 6803214 | Nucleic acids and new polypeptides associated with and/or overlapping with hepatitis C virus core gene products DNA encoding core+1 polypeptides of hepatitis C virus (HCV), nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed. ... | 10/12/2004 |
| 6803043 | Basbo27 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 10/12/2004 |
| 6803035 | Anti-diarrheal and method for using the same A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal wherein the egg product is obtained from a hyperimmunized avian.... | 10/12/2004 |
| 6800442 | Methods of selecting polynucleotides encoding antigens The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such antigens in immunogenic compositions or vaccines to induce regres... | 10/05/2004 |
| 6797273 | Neisseria meningitidis antigen The invention provides BASB053 polypeptides and polynucleotides encoding BASB053 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 09/28/2004 |
| 6797274 | Compounds The invention provides BASB047, BASB054, BASB068 and BASB069 polypeptides, and polynucleotides encoding BASBO47, BASB054, BASB068 and BASB069 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylact... | 09/28/2004 |
| 6794156 | Cell growth, induction and lysis in an antibody-coated microplate for use in an ELISA A competitive assay to determine the presence and concentration of an intracellular analyte (e.g., cAMP) in a sample is provided. All of the steps of the assay can be performed on the same assay plate, thereby eliminating the need to transfer the cells from a tissue... | 09/21/2004 |
| 6790630 | DNA and protein from Dirofilaria immitis In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known members include Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 and Av33. T... | 09/14/2004 |
| 6787145 | Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open ... | 09/07/2004 |
| 6780596 | Methods for determining the activity of complex mixtures According to the present invention, the biological or pharmacological activity of a test material like a plant or herbal material, an extract of a plant or herbal material, a natural or synthetic compound or some combination thereof, can be quantified by observing t... | 08/24/2004 |
| 6780417 | Transmission blocking immunogen from malaria The present invention relates to transmission blocking vaccines against malaria. Vaccines of the present invention contain a recombinant virus encoding all, or a unique portion, of the 25 kDa sexual stage surface protein of Plasmodium falciparum, Pfs25, or th... | 08/24/2004 |
| 6780419 | Basb029 polynucleotide(s) and polypeptides from neisseria meningitidis The invention provides BASB029 polypeptides and polynucleotides encoding BASB029 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 08/24/2004 |
| 6777547 | Collagen-binding proteins from streptococcus pyogenes Isolated proteins, designated Cpa1 and Cpa49, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by group A streptococcal bacteria such as Streptococcus pyogenes. The... | 08/17/2004 |
| 6777546 | Methods and substances for preventing and treating autoimmune disease A plant-based edible vaccine against autoimmune disease prepared by expressing a CTB-autoantigen chimeric gene construct in plant cells and transgenic plants is disclosed. DNA constructs, expression vectors comprising a nucleotide sequence that encodes a CTB-autoant... | 08/17/2004 |
| 6773712 | Parasitic helminth cuticlin proteins and uses thereof The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised against such cuticlin proteins; and compounds that inhibit parasitic hel... | 08/10/2004 |
| 6774218 | Mutants of streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 08/10/2004 |
| 6770284 | Polypeptides and polynucleotides BASB040 from neisseria meningitidis and vaccine comprising said polypeptides and polynucleotides The invention provides BASB040 polypeptides and polynticleotides from Neisseria meningitidis encoding BASB040 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. | 08/03/2004 |
| 6770459 | Immunogenic compounds The invention provides BASB081 polypeptides and polynucleotides encoding BASB081 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 08/03/2004 |
| 6770275 | Live attenuated RTX-producing bacteria of the family pasteurellaceae The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a non-activated form. The invention also relates to vaccines for the protection of... | 08/03/2004 |
| 6764834 | BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 07/20/2004 |
| 6752991 | Nucleic acids encoding a house dust mite allergen Der p III, and uses therefor Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids... | 06/22/2004 |
| 6750043 | Viral vectors having reduced virulence The present invention provides recombinant vaccinia virus having a deletion of the region encoding the C-terminal seven amino acids of the E3L gene product and comprising exogenous DNA. Compositions comprising the recombinant vaccinia virus and methods of use thereo... | 06/15/2004 |
| 6733757 | Adeno-associated virus capsid immunologic determinants Polypeptides of adeno-associated virus (AAV) that bind to AAV antibodies or block binding of AAV to mammalian cells are described. Derivatives of peptides can be less immunogenic, enhance binding to cells, render a virus tissue specific and so on. The nucleic acid s... | 05/11/2004 |
| 6730305 | Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins The present invention relates to recombinant DNA molecules which encode bovine respiratory syncytial (BRS) virus proteins, to BRS virus proteins, and peptides and to recombinant BRS virus vaccines produced therefrom. It is based, in part, on the cloning of substanti... | 05/04/2004 |
| 6723323 | Vibrio Cholerae vaccine candidates and method of their constructing Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA mutant of Vibrio cholerae and the general methodol... | 04/20/2004 |
| 6716431 | Differential cytotoxicity of alternative forms of rotavirus nonstructural protein 4 The nonstructural protein 4 (NSP4) in the SA11 ATCC rotavirus strain has a histidine at amino acid position 47. This substituted form is more cytotoxic than the NSP4 of the Australia rotavirus strain, which has an asparagine at amino acid position 47. The histidine ... | 04/06/2004 |
| 6716433 | Group a streptococcal vaccines The present invention provides immunogenic synthetic fusion polypeptide which stimulates an immune response against a selected pathogen, comprising at least two immunogenic polypeptides from a Group A streptococci of at least 10 amino acids in length which are capab... | 04/06/2004 |
| 6713284 | Bacterial superantigen vaccines The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen t... | 03/30/2004 |
| 6706495 | Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal ... | 03/16/2004 |
| 6706494 | BASB028 polypeptides and polynucleotides encoding therefor from moraxella catarrhalis The invention provides BASB028 polypeptides and polynucleotides encoding BASB028 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6706270 | Compounds The invention provides BASB041, 43, 44 and 48 polypeptides and polynucleotides encoding BASB041, 43, 44 and 48 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6706271 | Cloning of BASB023 antigen from Moraxella catarrhalis The invention provides BASB023 polypeptides encoding BASB023 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 03/16/2004 |
| 6706484 | Protein/(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ... | 03/16/2004 |
