Quotables
"Telephone, n. An invention of the devil which abrogates some of the advantages of making a disagreeable person keep his distance. "
Ambose Bierce
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6607729 | Surface antigen The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions containing the polypeptide and nucleic acids of the invention ar... | 08/19/2003 |
| 6607725 | Conjugate vaccine for nontypeable Haemophilus influenzae A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infect... | 08/19/2003 |
| 6605457 | Influenza vaccine A recombinant neuraminidase obtainable by culturing in a suitable culture medium host cells which are transformed with a neuraminidase expression vector or infected with a virus which is transformed with a neuraminidase expression vector, wherein the expr... | 08/12/2003 |
| 6605448 | Method and means for sorting and identifying biological information In one aspect the invention discloses a matrix comprising a discrete population of random oligopeptides of the same length, the length being selected from about 4 to about 12 L-amino acid residues, the population comprising at least 10% of all amino acid ... | 08/12/2003 |
| 6602506 | Delivery of proteins into eukaryotic cells with recombinant Yersinia The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.... | 08/05/2003 |
| 6599508 | Papilloma virus-like particles, fusion proteins as well as processes for their production The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papill... | 07/29/2003 |
| 6593463 | Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mamm... | 07/15/2003 |
| 6592873 | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproducti... | 07/15/2003 |
| 6589532 | Papilloma viruses, means for the detection thereof and therapy for diseases caused thereby The invention relates to DNA coding for a peptide of a papilloma virus major capsid protein or a papilloma virus genome. The invention also relates to proteins coded by the papilloma virus genome and antibodies directed against said proteins, in addition ... | 07/08/2003 |
| 6589755 | Assay for quantifying arthritic conditions The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons and polyclonal and monoclonal antibodies to the new COMP fra... | 07/08/2003 |
| 6589531 | Recombinant yellow fever virus and method of use thereof The present invention provides recombinant yellow fever viruses (YFV), particularly live attenuated recombinant YFV, which comprise exogenous (i.e., non-YFV) nucleotide sequences which encode exogenous (i.e., non-YFV) amino acid sequences. These recombina... | 07/08/2003 |
| 6589530 | Hepatitis B surface antigen vaccine HBV surface antigen particles, prepared by recombinant DNA technology are described, said particles being composed of epitopes from the group of surface peptides and/or core peptide of non-A, non-B hepatitis virus, hepatitis A virus, or hepatitis virus B.... | 07/08/2003 |
| 6579676 | Rapid mutational analysis method and compositions A novel rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The powerful, rapid, and simple method of the present invention... | 06/17/2003 |
| 6570061 | Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with human genes, either through conventional gene targeting, or b... | 05/27/2003 |
| 6569433 | Compounds and methods for the diagnosis and treatment of B. microti infection Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Anti... | 05/27/2003 |
| 6569635 | Growth state-specific immunofluorescent probes for determining physiological state and method of use A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody fluorochrome-coupled probe. Utilizing the method of the in... | 05/27/2003 |
| 6562348 | Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same The present invention provides a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine. The present invention also provides a vaccine comprising a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine, as well as a ... | 05/13/2003 |
| 6562597 | Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus ... | 05/13/2003 |
| 6555345 | Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus ... | 04/29/2003 |
| 6555347 | Human minor vault protein p193 A polynucleotide molecule encoding human minor vault protein p193, or its complementary strands. A purified and isolated polynucleotide molecule consisting essentially of a nucleotide sequence encoding human minor vault protein p193, or its complementary ... | 04/29/2003 |
| 6551820 | Expression of immunogenic hepatitis B surface antigens in transgenic plants Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, includi... | 04/22/2003 |
| 6551594 | Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in said method The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infec... | 04/22/2003 |
| 6551597 | Vaccine compositions for human papillomavirus Large quantities of soluble multimers of human papillomavirus L1 proteins can be produced in bacterial expression systems and used as therapeutic and diagnostic tools. L1 multimers can be used in immunogenic vaccine compositions, as diagnostic reagents, a... | 04/22/2003 |
| 6548287 | Non-pyrogenic bacterial strains and use of the same The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the... | 04/15/2003 |
| 6544522 | Fusion proteins of mycobacterium tuberculosis antigens and their uses The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigen... | 04/08/2003 |
| 6541459 | Soluble herpesvirus glycoprotein complex vaccine The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA encoding a herpes simplex virus glycoprotein H-glycoprotein L... | 04/01/2003 |
| 6538126 | Hepatitis C diagnostics and vaccines The present invention provides polynucleotides derived from cDNA of novel type of hepatitis C virus named Korean type hepatitis C virus (KHCV), polypeptides encoded therein, and antibodies directed against the polypeptides; and also provide diagnostics an... | 03/25/2003 |
| 6537556 | Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation process A polypeptide useful as an immunogen element and characterized in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine res... | 03/25/2003 |
| 6537594 | Vaccina virus comprising cytokine and/or tumor associated antigen genes Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses.... | 03/25/2003 |
| 6537769 | Purified and recombinant antigenic protein associated with abdominal aortic aneurysm (AAA) disease, and diagnostic and therapeutic use thereof This invention provides an isolated protein of approximately 40 kDa which is purified from human aortic tissue and immunoreactive with AAA-associated immunoglobulin. Also provided are a method of diagnosing AAA disease in a subject using said isolated pro... | 03/25/2003 |
| 6534638 | Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections The present invention provides nucleic acid molecules containing nucleotide sequences encoding helminth aminopeptidase enzymes, and antigenic fragments and functionally-equivalent variants thereof, their use in the preparation of vaccines for use against ... | 03/18/2003 |
| 6531313 | Invasive bacterial vectors for expressing alphavirus replicons The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to be expressed in the animal or the animal cells. The bacteri... | 03/11/2003 |
| 6528063 | Recombinant vaccines against IBDV There is provided a stable vaccine for providing protection against disease having viral proteins transgenically expressed in plant cells. Also provided is a stable vaccine which provides protection against disease containing viral protein and coding sequ... | 03/04/2003 |
| 6524588 | Attenuated vaccination and gene-transfer virus, a method to make the virus and a pharmaceutical composition comprising the virus RNA polymerase I transcription in vivo in transiently DNA-transfected cells has been used for expression of influenza vRNA molecules coding for chloramphenicol acetyltransferase (CAT) in anti-sense orientation. Influenza virus superinfection served to pro... | 02/25/2003 |
| 6525173 | Process for expression and production of recombinant protein hybrid protein (p24/p17) derived from human immunodeficiency viruses (HIV-1) The present invention describes recombinant p24/p17 hybrid protein derived from the human immunodeficiency virus, their corresponding encoding recombinant DNA molecule and the process of production of the recombinant protein produced through genetic engin... | 02/25/2003 |
| 6521746 | Polynucleotides encoding LKT 111 New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at leas... | 02/18/2003 |
| 6517844 | Compositions and method for immunizing polutry The present invention is directed to vaccine compositions and methods for immunizing poultry. The vaccine compositions comprise inactivated bacterial organisms which can be administered to the poultry through oral intake of water.... | 02/11/2003 |
| 6514727 | Antimicrobial theta defensins and methods of using same The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-X... | 02/04/2003 |
| 6514501 | Recombinant vaccine against dengue virus A recombinant protein encompassing the complete envelope glycoprotein and a portion of the carboxy-terminus of the membrane/premembrane protein of dengue 2 virus was expressed in baculovirus as a protein particle. The recombinant protein particle was puri... | 02/04/2003 |
| 6509017 | 66 KDA antigen from Borrelia The present invention relates to nucleic acid molecules, polypeptides encoded by the same, antibodies directed thereto and a method of preparing such polypeptides including: (a) inserting an isolated DNA molecule coding for a polypeptide which is immunore... | 01/21/2003 |
