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| Number | Title | Issue Date |
| 8029986 | KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detect... | 10/04/2011 |
| 8026050 | Methods for modifying an oligonucleotide The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided ... | 09/27/2011 |
| 8026051 | PNA probes, probe sets, methods and kits pertaining to the detection of This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be sel... | 09/27/2011 |
| 8026057 | Nucleic acid labeling compounds Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminal... | 09/27/2011 |
| 8026058 | PCR hot start by magnesium sequestration The present invention is directed to a synthetic peptide having a length of not more than 30 amino acids comprising a divalent cation binding site. Such a peptide according to the present invention is part of a composition for nucleic acid amplification and provides... | 09/27/2011 |
| 8026059 | Treatment response in generalized social phobia This invention generally pertains to the field of psychiatry. In particular, this invention relates to, inter alia, the discovery that a subject's serotonin transporter gene promoter polymorphism genotype can be used to determine the subject's response to certain dr... | 09/27/2011 |
| 8026061 | Probe, probe set, probe carrier, and testing method A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishing... | 09/27/2011 |
| 8026055 | Materials and methods for prognosing lung cancer survival The invention provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups. The invention also includes kits for use in the methods of the invention. ... | 09/27/2011 |
| 8026060 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 09/27/2011 |
| 8026056 | Compositions and methods for detecting Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segme... | 09/27/2011 |
| 8026053 | Mutations of the PIK3CA gene in human cancers Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is freq... | 09/27/2011 |
| 8026054 | Antibodies against cells of fetal origin This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood. | 09/27/2011 |
| 8026052 | Delivery of nucleic acids into eukaryotic genomes using in vitro assembled Mu transposition complexes The present invention relates to genetic engineering and especially to the use of DNA transposition complex of bacteriophage Mu. In particular, the invention provides a gene transfer system for eukaryotic cells, wherein in vitro assembled Mu transposition complexes ... | 09/27/2011 |
| 8021840 | Diagnostic marker for interferon responsiveness in multiple sclerosis Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon the... | 09/20/2011 |
| 8021837 | Detection of chromosomal abnormalities associated with breast cancer Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially remov... | 09/20/2011 |
| 8021842 | Nucleic acid analysis using sequence tokens The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, whi... | 09/20/2011 |
| 8021836 | Method of diagnosing infectious disease by measuring the level of soluble TREM-1 in a sample The present invention concerns a method of diagnosing disease of bacterial or fungal origin in a subject, which method comprises the step of measuring the level of Strem-1 in a biological sample obtained from said subject. ... | 09/20/2011 |
| 8021839 | Methods and compositions for detecting polynucleotides Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of t... | 09/20/2011 |
| 8021838 | Transcriptional regulation of target genes The present invention describes a method of identifying inducible genetic regulatory sequences that can control the transcription of specific gene transcripts. Methods of using inducible genetic regulatory sequences are also discussed. In particular, the genetic reg... | 09/20/2011 |
| 8021841 | Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology Methods and apparatuses for analyzing biomolecules are presented. The methods include dividing of sample molecules into multiple fragments, spatially separating these fragments while maintaining knowledge of their original ordering, and analyzing individual fragment... | 09/20/2011 |
| 8017330 | Artificial chimeras engineered to simulate multiple biological threat agents This invention provides safe, non-infectious chimeras that include the nucleic acid signature of most bacterial and viral biological threat agents. These chimeras mimic properties of threat agents and are useful as simulants to develop, evaluate, test, and train on ... | 09/13/2011 |
| 8017559 | Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains The present invention provides novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target compounds and also provides nucleic acids encoding the polypeptides. The p... | 09/13/2011 |
| 8017329 | Method of screening baff suppressor or inhibitor A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a m... | 09/13/2011 |
| 8017318 | Method for detecting and/or quantifying a known function from a nucleic acid sample The invention concerns a method for detecting a known function, from nucleic acids present in a sample, characterized in that it comprises the following steps: (a) preparing, from the nucleic acids of the sample, nucleic acid molecules comprising the gene(s) coding ... | 09/13/2011 |
| 8017324 | ENPP1 (PC-1) gene haplotype associated with the risk of obesity and type 2 diabetes and their applications The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or... | 09/13/2011 |
| 8017326 | Methods of modulating cell death based on the Bit-1/AES regulatory pathway The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or acti... | 09/13/2011 |
| 8017325 | Selection of high-producing cell lines The invention describes a method for screening antibody producing cell lines for selection of high expressing clones. ... | 09/13/2011 |
| 8017319 | Evanescence-based multiplex sequencing method The invention relates to a method and a device for evanescence-based multiplex sequencing of nucleic acid molecules immobilized on a support. ... | 09/13/2011 |
| 8017322 | Method for rapid detection and identification of bioagents Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived f... | 09/13/2011 |
| 8017323 | Free reactant use in nucleic acid-templated synthesis The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates ... | 09/13/2011 |
| 8017327 | Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform A method and apparatus for real-time, simultaneous, quantitative measurement for detecting a single nucleotide polymorphism in a target nucleic acid is provided. This method involves combining a polymerase chain reaction (PCR) technique with invader assay technique.... | 09/13/2011 |
| 8017320 | Method of detecting metastasizing cancer cells originating in stomach cancer Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biologica... | 09/13/2011 |
| 8017328 | Genome partitioning using a nicking endonuclease A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-strand... | 09/13/2011 |
| 8017321 | Gefitinib sensitivity-related gene expression and products and methods related thereto Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to gefitinib and other EGFR inhibitors, and products and processes related thereto. Specifically, a method is described for selecting a cancer patient ... | 09/13/2011 |
| 8012680 | Microchip, nucleic acid extracting kit, and nucleic acid extracting method A new technical means is provided that can be produced and prepared at low cost, and in which the generation of stagnation in the flow of a liquid sample can be suppressed, microbeads can be smoothly and simply injected, filled and transported and the generation of ... | 09/06/2011 |
| 8012681 | Methods of modulating metastasis and skeletal related events resulting from metastases The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and m... | 09/06/2011 |
| 8012682 | Nucleic acids encoding chromophores/fluorophores and methods for using the same Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein.... | 09/06/2011 |
| 8012688 | Gene expression profiling from FFPE samples Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can be electronically stored and implemented as well as used to augment diagnosis and treatment of diseas... | 09/06/2011 |
| 8012687 | Isolated genomic polynucleotide fragments from chromosome 19 that encode human resistin and the human syntaxin binding protein 2 The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides ... | 09/06/2011 |
| 8012685 | Detection of analytes and nucleic acids Methods of detecting at least one analyte and at least one nucleic acid in a sample are provided. Reagents for carrying out the methods are also provided. ... | 09/06/2011 |
