Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 7951542 | Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a SULT4A1-1 haplotype are described. Furthermore, the invention provides methods and comp... | 05/31/2011 |
| 7951543 | Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a SULT4A1-1 haplotype are described. Furthermore, the invention provides methods and comp... | 05/31/2011 |
| 7951541 | Assay kit for use in method of detecting a target nucleic acid Kits for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and B3 | 05/31/2011 |
| 7951539 | Two-stage nucleic acid amplification using an amplification oligomer This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a se... | 05/31/2011 |
| 7951540 | Sequences diagnostic for shrimp pathogens Primers have been isolated that are diagnostic for the detection of Vibrio harveyi. The primers are based on a portion of the Vibrio harveyi LuxR gene and may be used in primer directed amplification or nucleic acid hybridization assay methods. ... | 05/31/2011 |
| 7951536 | Method for determining base sequence of DNA The present invention provides a method for determining the base sequence of a DNA. According to the method for determining the base sequence of a DNA of the present invention, a probe is used, which is a probe having a protruding end and identification-labeled acco... | 05/31/2011 |
| 7951537 | Development of low allergen soybean seeds using molecular markers for the P34 allele A mutation in the gene encoding the P34 protein in soybean which affects allergenicity is characterized. Soybean homozygous for a mutant allele comprising a four base pair insertion at the start codon of the gene encoding the P34 protein, exhibit significantly reduc... | 05/31/2011 |
| 7951534 | Hot start nucleic acid amplification Methods and compositions for performing nucleic acid duplication and amplification reactions are provided. A single-stranded nucleic acid binding protein is selected and provided in the reaction mixture which is assembled at a low, nonstringent temperature to includ... | 05/31/2011 |
| 7951538 | Method to determine the risk for side effects of an SSRI treatment in a person A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor gene. This provides for a method to improve the treatment o... | 05/31/2011 |
| 7951535 | SERS molecular probe for diagnostics and therapy and methods of use thereof An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the lo... | 05/31/2011 |
| 7947455 | System for genome selection Systems, methods, compositions and apparatus relating to genome selection are disclosed. ... | 05/24/2011 |
| 7947456 | Assessing brain aneurysms This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm r... | 05/24/2011 |
| 7947457 | Systems for genome selection Systems, methods, compositions and apparatus relating to genome selection are disclosed. ... | 05/24/2011 |
| 7947448 | Use of regulatory sequences for specific, transient expression in neuronal determined cells The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences f... | 05/24/2011 |
| 7947452 | Oligonucleotides originating from sequences coding for the surface component of PTLV envelope proteins and their uses The invention relates to the use of oligonucleotides from the nucleotide sequences coding for the amino-terminal region of the surface component (SU) of envelope proteins of PTLV viruses in order to perform methods of detecting every PTLV strain or PTLV-related viru... | 05/24/2011 |
| 7947449 | Methods of diagnosing pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 05/24/2011 |
| 7947451 | Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid... | 05/24/2011 |
| 7947450 | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of ... | 05/24/2011 |
| 7947445 | Method of detecting DNA of A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishing... | 05/24/2011 |
| 7947446 | High throughput mutation screening methods and kits using a universalized approach—differential sequence fill-in (DSF)-enabled sequential adapter ligation and amplification This disclosure teaches high throughput mutation screening methods allowing simultaneous analysis of multiple genetic regions of interest and sensitive detection of very low frequency mutation(s) by the use of a universalized approach. Methods comprise treating RNA:... | 05/24/2011 |
| 7947447 | Method for generating aptamers with improved off-rates The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target... | 05/24/2011 |
| 7947453 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 05/24/2011 |
| 7947442 | Apparatus for emitting and detecting light in a nucleic acid amplification reaction Subject of the present invention is to provide an apparatus, an instrument, and a method particularly useful in multiplex PCR applications permitting short sample measuring times of many samples combined with high sensitivity. ... | 05/24/2011 |
| 7947443 | DNA and RNA conformational switches as sensitive electronic sensors of analytes The electrical conductivity of DNA and other oligonucleotide constructs is dependent on its conformational state. Such a dependence may be harnessed for the electronic sensing of external analytes, for instance, adenosine or thrombin. Such a DNA sensor incorporates ... | 05/24/2011 |
| 7947440 | Method for determining the specific growth rate of a distinct cell population within a non-homogeneous system The present invention provides a method for measuring the specific rate of ribosome synthesis for a distinct cell population, such as a distinct microbial population. For an actively growing (or non-growing) culture, the specific rate of ribosome synthesis is identi... | 05/24/2011 |
| 7947444 | Leptin promoter polymorphisms and uses thereof The present invention relates to single nucleotide polymorphisms (SNPs) in the leptin promoter, and to methods for the identification of animals carrying specific alleles of these SNPs that are associated with circulating leptin levels, feed intake, growth rate, bod... | 05/24/2011 |
| 7947454 | Methods and apparatus for characterizing polynucleotides Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase,... | 05/24/2011 |
| 7947441 | Molecular detection and quantification of Enterococci A primer pair and probe for the large subunit ribosomal RNA gene of enterococci for use in a real-time nucleic acid sequence based amplification (NASBA) assay. ... | 05/24/2011 |
| 7943300 | Method for improved protein expression in bacteria by monitoring and modulating protein folding This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the perip... | 05/17/2011 |
| 7943301 | DNA conformational switches as sensitive electronic sensors of analytes The electrical conductivity of DNA and other oligonucleotide constructs is dependent on its conformational state. Such a dependence may be harnessed for the electronic sensing of external analytes, for instance, adenosine. Such a DNA sensor incorporates an analyte r... | 05/17/2011 |
| 7943318 | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provide methods of identifying anti-lung cancer agents. ... | 05/17/2011 |
| 7943302 | C20ORF23 as modifier of the IGFR pathway and methods of use Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C... | 05/17/2011 |
| 7943319 | Utility of RET mutant in diagnosis and treatment of melanoma The invention relates to a method of detecting a RET mutant in a melanoma cell. Also disclosed is a method of modulating the activity of a RET mutant in a melanoma cell with an agent that interferes with the activity of the RET mutant. ... | 05/17/2011 |
| 7943317 | Polymorphism in the Apo(a) gene predict responsiveness to acetylsalicylic acid treatment This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid. ... | 05/17/2011 |
| 7943303 | Method for engineering strand-specific nicking endonucleases from restriction endonucleases Methods are provided for engineering novel strand-specific nicking endonucleases by means of an in vivo enrichment of a plasmid library containing a randomly mutagenized restriction endonuclease gene. The plasmids contain adjacent to the gene a cleavable or nickable... | 05/17/2011 |
| 7943320 | Unsymmetrical cyanine dyes for high resolution nucleic acid melting analysis The present invention relates to novel unsymmetrical cyanine dyes and to methods of performing nucleic acid analysis in the presence of such dyes. More specifically, the present invention relates to novel unsymmetrical cyanine dyes that have high affinity to double-... | 05/17/2011 |
| 7943316 | Immunostimulatory oligonucleotides and uses thereof Oligonucleotides containing the non-palindromic sequence motif: X1X2X3X4X5X6X7X8, wherein X1 is C, T, G or A (preferably T... | 05/17/2011 |
| 7943304 | Method and apparatus for chromosome profiling A method and apparatus for generating an Interphase chromosome profile. The method comprises obtaining a sample containing cells having chromosomes for profiling; obtaining species specific DNA probes, wherein the DNA probes are capable of marking at least one chrom... | 05/17/2011 |
| 7943321 | Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter. | 05/17/2011 |
| 7943315 | Methods for testing milk The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety. ... | 05/17/2011 |
