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| Number | Title | Issue Date |
| 7678543 | Method for amplifying genomic DNA A method for amplifying genomic DNA is provided. The method comprises the steps of: (1) incubating a cell-containing agarose solution at a pH of 9 to 12 and a temperature of 45 to 80° C. to produce a genomic DNA-dispersed agarose solution wherein 0.002 to 1 copies/... | 03/16/2010 |
| 7678541 | Methods and compositions for the detection of a nucleic acid using a non-invasive cleavage reaction The invention provides methods, compositions and kits for generating a signal indicative of the presence of a target nucleic acid sequence in a sample comprising forming a cleavage structure by incubating a sample comprising a target nucleic acid sequence with upstr... | 03/16/2010 |
| 7678542 | Charge tags and the separation of nucleic acid molecules The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or d... | 03/16/2010 |
| 7674581 | Autonomous genosensor apparatus An autonomous genosensor apparatus and methods for use are provided for the field detection and analysis of ambient chemical, biochemical, biologic, biogenetic, and radiologic materials under field conditions in fluid or gaseous environments, such as marine or aquat... | 03/09/2010 |
| 7674583 | Alterations in the copy number of the SULT1A1 gene Methods are described for determining sulfonator status of a patient and determining dosages of drugs based on copy number of the SULT1A1 gene. ... | 03/09/2010 |
| 7674582 | Methods for amplification monitoring and gene expression profiling, involving real time amplification reaction sampling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 03/09/2010 |
| 7674589 | Methods for tissue analysis This invention relates to methods of analyzing a tissue sample from a subject. In particular the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. Th... | 03/09/2010 |
| 7674588 | Screening using polarization anisotropy in FRET emissions Methods and apparatus are described for detecting specific binding between first and second chemical entities. The first chemical entity in association with a first fluorophore is immobilized. The second chemical entity is allowed to bind with the immobilized first ... | 03/09/2010 |
| 7674585 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 03/09/2010 |
| 7674580 | Compositions and methods for the modulation of sphingolipid metabolism and/or signaling Compositions, methods and kits for diagnosing and treating cancer and muscular disorders are provided. Therapeutic compositions may comprise agents that modulate sphingolipid metabolism and/or signaling pathways. Such compositions may be administered to a mammal aff... | 03/09/2010 |
| 7674586 | Methods of identifying modulators of L-glutamate-gated chloride channel proteins from The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a... | 03/09/2010 |
| 7674584 | Method for measuring binding of a test compound to a G-protein coupled receptor The invention provides a method for measuring binding of a test compound to a G-Protein Coupled Receptor (GPCR). The invention also provides a method for identifying and measuring the effect that an agent has upon modulating the binding of a test compound to a G-Pro... | 03/09/2010 |
| 7674587 | Polymorphism detection The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complement... | 03/09/2010 |
| 7670779 | Nucleotide mixture for improved nucleic acid amplification performance The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification. In particular, the present invention provides methods and buffers for performing... | 03/02/2010 |
| 7670780 | Compositions and methods to detect nucleic acid Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Candida albicans 26S rRNA sequences or DNA encoding 26S rRNA. Methods... | 03/02/2010 |
| 7670776 | MYH gene variants and use thereof Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing ca... | 03/02/2010 |
| 7670770 | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as... | 03/02/2010 |
| 7670771 | Mutant sodium channel Na1.7 nucleic acid methods Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1 sodium channel alpha-subunit, methods for d... | 03/02/2010 |
| 7670772 | Microfluidic chip for multiple bioassay and method of manufacturing the same Provided are a microfluidic chip for multiple bioassay and a method of manufacturing the same. The method includes: forming microfluidic channels by coupling a channel structure having grooves for sample channels and probe channels in a bottom surface and a substrat... | 03/02/2010 |
| 7670773 | MECP2E1 gene The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders. ... | 03/02/2010 |
| 7670769 | IL1RL-1 as a cardiovascular disease marker and therapeutic target This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hyp... | 03/02/2010 |
| 7670767 | Genetic alterations associated with cancer The present invention provides new probes for the detection of chromosomal alterations associated with cancer, particularly ovarian cancer. The probes bind selectively with target nucleic acid sequences at 3q26. ... | 03/02/2010 |
| 7670774 | Probe of human papillomavirus and DNA chip comprising the same Oligonucleotide probes for analyzing 40 types of HPV were synthesized, and DNA chips were produced by using the oligonucleotide probes. The synthesis of the oligonucleotide probes is based on clones of L1 and E6/E7 genes of 35 types of HPV obtained from cervical cel... | 03/02/2010 |
| 7670768 | Processes for isolating, amplifying and characterizing DNA Processes for isolating, amplifying, and characterizing DNA from biological materials are provided. DNA is isolated by contacting a biological material on a solid support which is preferably pre-treated with a lysing reagent. The isolation process is simple and effi... | 03/02/2010 |
| 7670777 | Method for detecting DNA methylation using labelled S-adenosylmethionine analogs The invention relates to a method for detecting the methylation status in DNA samples. According to the invention, a DNA methyl transferase and a labeled S-adenosylmethionine derivative allow a detectable label to be covalently bonded to the DNA, in accordance with ... | 03/02/2010 |
| 7670778 | Tumor suppressor pathway in The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their enc... | 03/02/2010 |
| 7670775 | Method for differentiating malignant from benign thyroid tissue Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided. ... | 03/02/2010 |
| 7666602 | Method for agitating the fluid contents of a container An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat... | 02/23/2010 |
| 7666603 | Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a me... | 02/23/2010 |
| 7666601 | Phenylthiocarbamide (PTC) taste receptor The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, an... | 02/23/2010 |
| 7666819 | Integrated micro array system and methods therefor Various methods are provided for an integrated micro array system (100) that allows fully automated sample processing and detection/quantification of nucleic acid and protein samples in a single analytical device, which may be configured to communicate data t... | 02/23/2010 |
| 7666600 | Cross-reactive primers for amplifying the nucleic acids of HIV-1 and HIV-2 Compositions, methods and kits for detecting the nucleic acids of HIV-1, HIV-2, or the combination of HIV-1 and HIV-2. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers, including cross-reacting hybridizati... | 02/23/2010 |
| 7666596 | Tissue rejection This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. ... | 02/23/2010 |
| 7666595 | Biomarkers for predicting prostate cancer progression The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated... | 02/23/2010 |
| 7666597 | Marker for tardive dyskinesia The present invention discloses markers for tardive dyskinesia. Also disclosed is a method of determining the risk of tardive dyskinesia from antipsychotic medication in a subject, the method comprising the step of genotyping a sample obtained from the subject for t... | 02/23/2010 |
| 7666593 | Single molecule sequencing of captured nucleic acids The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques. ... | 02/23/2010 |
| 7666592 | Methods for concurrent identification and quantification of an unknown bioagent The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent ide... | 02/23/2010 |
| 7666594 | Methods for assaying a sample for an aggregant This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be trans... | 02/23/2010 |
| 7666598 | Recombinase polymerase amplification This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence spec... | 02/23/2010 |
| 7666590 | Identification of fat and lean phenotypes in chickens using molecular markers The present invention provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism associated with a fat or lean phenotype. ... | 02/23/2010 |