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| Number | Title | Issue Date |
| 8168434 | Process for chromosomal integration and DNA sequence replacement in The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a... | 05/01/2012 |
| 8148155 | Methods for increasing homologous recombination of a nucleic acid sequence The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombina... | 04/03/2012 |
| 7972857 | Methods for the replacement, translocation and stacking of DNA in eukaryotic genomes The present invention includes compositions and methods for site-specific polynucleotide replacement in eukaryotic cells. These methods include single polynucleotide replacement as well as gene stacking methods. Preferred eukaryotic cells for use in the present inve... | 07/05/2011 |
| 7413732 | Baculovirus expression system The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid sequence which is capable of restoring replication in the replication-d... | 08/19/2008 |
| 7364745 | Development of a live, attenuated, recombinant vaccine for Brucellosis A recombinant, attenuated strain of Brucella suis or Brucella melitensis with a deficiency in carboxyl-terminal protease activity or tail-specific protease activity can be used as a vaccine for the prevention or treatment of Brucellosis. Prior exposure... | 04/29/2008 |
| 7335470 | Compilations of nucleic acids and arrays and methods of using them In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p... | 02/26/2008 |
| 7332341 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells The present invention relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells. ... | 02/19/2008 |
| 7320793 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 01/22/2008 |
| 7317216 | Ultrasensitive biochemical sensing platform An electronic sensor is provided for detecting the presence of one or more targets of interest in a sample. The sensor preferably comprises a special type of field effect transistor in which conductance is enhanced by target binding to recognition elements in the ac... | 01/08/2008 |
| 7309605 | Nucleotide sequence encoding the enzyme I-I and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 12/18/2007 |
| 7303906 | Competent bacteria The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced... | 12/04/2007 |
| 7271000 | Nucleotide sequence encoding the enzyme I-Scel and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 09/18/2007 |
| 7264810 | Molecular antigen array The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for produc... | 09/04/2007 |
| 7229813 | Everninomicin biosynthetic proteins This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. T... | 06/12/2007 |
| 7229624 | Ordered molecular presentation of antigens, method of preparation and use The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatme... | 06/12/2007 |
| 7214536 | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 05/08/2007 |
| 7199107 | Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using th... | 04/03/2007 |
| 7175983 | Adapter-directed display systems The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. This subject systems are particularly useful for displaying... | 02/13/2007 |
| 7129079 | Cells engineered to contain genes of interest Methods and materials are provided for stably introducing any gene into a specific locus in the genome of a microorganism such as yeast without the addition of any drug resistance genes. Specifically provided herein are new genetically engineered inositol-overproduc... | 10/31/2006 |
| 7126041 | High efficiency gene targeting in plants The present invention provides a method for the targeted insertion of a nucleotide of interest into a specific chromosomal site within a plant cell. The method comprises the steps of: (a) providing a plant cell, the plant cell optionally but preferably having a hete... | 10/24/2006 |
| 7115266 | Angiotensin peptide-carrier conjugates and uses thereof The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like parti... | 10/03/2006 |
| 7101684 | Modified modular polyketide synthase Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides. ... | 09/05/2006 |
| 7094409 | Antigen arrays for treatment of allergic eosinophilic diseases The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein ... | 08/22/2006 |
| 7070930 | Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus The present invention provides an improved method of making eukaryotic gene transfer vectors comprising homologous recombining lambdid vectors with a second DNA in a bacterium to generate novel recombinant eukaryotic viral gene transfer vectors as well as a novel la... | 07/04/2006 |
| 7056728 | Compositions and methods for use thereof in modifying the genomes of microorganisms The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with ... | 06/06/2006 |
| 7049145 | Vaccinia virus MVA-E3L-knockout-mutants and use thereof The present invention relates to mutant MVA vaccinia viruses, which are used for the generation of recombinant MVA viruses, as well as host cells, which have been infected with these mutant MVA viruses. The present invention further relates to DNA-vector constructs,... | 05/23/2006 |
| 7049100 | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of no... | 05/23/2006 |
| 7033814 | Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase. The yeast is transformed by an integrating plasmid, which includes a Candida utilis biotin synthase gene BIO2, an assistant DNA sequence to prom... | 04/25/2006 |
| 7001748 | Methods of making polyketides using hybrid polyketide synthases Linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides... | 02/21/2006 |
| 6964866 | Methods and compositions for highly efficient transformation of filamentous fungi Applicants have devised a highly effective, convenient, and expeditious genetic transformation system for filamentous fungi, such as Agaricus bisporus. The preferred method uses an Agrobacterium-mediated transformation protocol. The critical features o... | 11/15/2005 |
| 6929915 | Methods for nucleic acid manipulation A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The... | 08/16/2005 |
| 6927057 | Macrolide analogs Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compoun... | 08/09/2005 |
| 6924118 | Recombinant intracellular pathogen immunogenic compositions and methods for use Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens are provided. Exemplary immunogenic compositions include, but are n... | 08/02/2005 |
| 6902913 | Recombinant narbonolide polyketide synthase Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antib... | 06/07/2005 |
| 6830885 | Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature This invention relates to the screening of nucleic acids. More particularly, the present invention provides a dysfunctional viral genome capable of both expressing libraries of exogenous nucleic acids and selecting the sequences having a predefined characteristic or... | 12/14/2004 |
| 6830920 | Rapid generation of recombinant adenoviral vectors The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombina... | 12/14/2004 |
| 6830910 | Drosophila recombination-associated protein and methods for use The invention encompasses Drosophila Recombination Associated Protein (DRAP) isolated D. melanogaster and a nucleic acid sequence encoding DRAP. The Drosophila Recombination Associated Protein, its homologues from other organisms or active peptides derived th... | 12/14/2004 |
| 6828093 | Rapid subcloning using site-specific recombination The present invention provides compositions, including vectors, and methods for the rapid subcloning of nucleic acid sequences in vivo and in vitro. In particular, the invention provides vectors used to contain a gene of interest that comprise a sequence-specific re... | 12/07/2004 |
| 6808896 | Method for stable chromosomal multi-copy integration of genes The present invention solves the problem of integrating multiple copies of a gene of interest by homologous recombination into well defined positions adjacent to conditionally essential genes in a bacterial host strain chromosome, which already comprises at least on... | 10/26/2004 |
| 6762040 | Method for increasing gene copy number in a host cell and resulting host cell The invention relates to a method for increasing the copy number of a chromosomally integrated expression cassette in a microbial strain without leaving antibiotic resistance markers behind in the strain, the necessary genetic constructs, and the strains resulting f... | 07/13/2004 |
