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| Number | Title | Issue Date |
| 7384640 | Mutant cholera holotoxin as an adjuvant A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an adjuvant in an antigenic composition to enhance the immune response in a... | 06/10/2008 |
| 7252942 | Parallel chromosomal stacking of traits in bacteria The invention describes a method for the stacking of traits in a recombination proficient host using a phage transduction system. The method makes use of a nucleic acid integration cassette that has homology to a specific site on a host chromosome for the insertion ... | 08/07/2007 |
| 7232564 | Methods of polyvalent bacteriophage preparation for the treatment of bacterial infections The multivalent strains of bacteriophages, methods of obtaining these and their use in the treatment of bacterial infections, particularly those of drug-resistant bacterial strains, especially arising in mucoviscidosis patients, are provided. ... | 06/19/2007 |
| 7135287 | Human antibodies The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target o... | 11/14/2006 |
| 7118915 | Muteins of apolipoprotein D A method for generating a mutein of human apolipoprotein D having detectable affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of: (a) subjecting the apolipoprotein D to mutagenesis at the sequence positions 34 to 38,... | 10/10/2006 |
| 7112435 | Uncoupling of DNA insert propagation and expression of protein for phage display The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage co... | 09/26/2006 |
| 7049135 | Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore, the invention relates to products and uses thereof for the identificat... | 05/23/2006 |
| 7033607 | pH-titratable polyampholytes for delivering polyions to a cell A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrava... | 04/25/2006 |
| 7022336 | Methods for attaching proteins to lipidic microparticles with high efficiency The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragmen... | 04/04/2006 |
| 6982087 | Vectors derived from South African Arbovirus No. 86 Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral vectors and helper constructs comprising a S.A.AR86 capsid enhancer sequen... | 01/03/2006 |
| 6962810 | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac More efficient transfer of genes into host cells or embryos to transform the cells or embryos is facilitated by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed cells or emb... | 11/08/2005 |
| 6943012 | Helper dependent adenoviral vector system and methods for using the same A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human stuffer DNA that provides for in vivo long term, high level expression o... | 09/13/2005 |
| 6924118 | Recombinant intracellular pathogen immunogenic compositions and methods for use Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens are provided. Exemplary immunogenic compositions include, but are n... | 08/02/2005 |
| 6924146 | Method of constructing vectors for homologous recombination directed mutagenesis The present invention provides a novel vector system and thereby a novel method for the simplified construction of recombinant vectors for directed mutagenesis. Said vector system is used to modify the eukaryotic genome, particularly of embryonic stem cells, at prec... | 08/02/2005 |
| 6919091 | Compositions and methods for drug delivery using pH sensitive molecules An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 07/19/2005 |
| 6884623 | Modified plant viruses as vectors of heterologous peptides The invention relates to assembled particles of a plant virus containing a foreign peptide insert in the coat protein of the virus. The site of the insert is preferably free from direct sequence repeats flanking the insert. The invention relates to a method of produ... | 04/26/2005 |
| 6881576 | Formation of polyampholytes in the presence of a polyion A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrava... | 04/19/2005 |
| 6800288 | Recombinant influenza A viruses The invention relates to a recombinant NS gene of an influenza A virus comprising a functional RNA binding domain and a gene sequence modification after nucleotide position 400 of the NS1 gene segment, counted on the basis of influenza A/PR/8/34 Virus, wherein the m... | 10/05/2004 |
| 6787360 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain specified char... | 09/07/2004 |
| 6780618 | Method for improving genetic stability of foreign insert nucleotide sequence in recombinant poliovirus The present invention relates to (a) methods for improving a genetic stability of an insert nucleotide sequence in a recombinant single-stranded RNA virus vector, which comprises performing a mutagenesis of the foreign insert nucleotide sequence to provide even dist... | 08/24/2004 |
| 6740336 | Process for generating multilayered particles We describe a process for generating multilayer particles comprising condensing a polymer with an oppositely charged polymer to form a particle and sequentially adding oppositely charged polymers to the particle forming at least three layers of polymers. The process... | 05/25/2004 |
| 6719978 | Virus-like particles for the induction of autoantibodies The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles,... | 04/13/2004 |
| 6696278 | Method for transfer of DNA segments The present invention provides a method of transfer of a gene of interest from a first vector to a product vector comprising contacting a first and second vector in vitro with a site-specific recombinase so as to generate a co-integrate vector comprising ... | 02/24/2004 |
| 6696295 | Transducing phages The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient... | 02/24/2004 |
| 6682729 | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression cassette encoding the gene. The gene may encode, e.g., a vac... | 01/27/2004 |
| 6653111 | Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine The present invention provides a method for deriving an E. coli strain which produces L-theronine from E.coli strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a transposon.... | 11/25/2003 |
| 6645763 | Immortalized bone marrow mesenchymal stem cell The present invention provides a safe immortalized bone marrow mesenchymal stem cell obtained by transferring a cell proliferation factor gene inserted between a pair of site-specific recombination sequences to a bone marrow mesenchymal stem cell.... | 11/11/2003 |
| 6608187 | C1 bacteriophage lytic system The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacter... | 08/19/2003 |
| 6589732 | Transducing phages The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient... | 07/08/2003 |
| 6586182 | Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.... | 07/01/2003 |
| 6537813 | Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby The invention relates generally to methods and apparatuses that are adapted for the preparation of gene therapeutic compositions, as well as the compositions formed thereby. The invention also relates to methods adapted for making mixtures and condensate ... | 03/25/2003 |
| 6521440 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells h... | 02/18/2003 |
| 6500611 | Inviable virus particles as scaffolds for constructing flexible detection systems An innovative detection system for detecting small numbers of target analytes is disclosed. This system provides a novel method for attaching multiple copies of reporter groups to a single site on an analyte of interest. This system preferably comprises a... | 12/31/2002 |
| 6482632 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain spe... | 11/19/2002 |
| 6410258 | Molecular hydrogen production by direct electron transfer The present invention discloses a method for making hydrogen with biological components including photosystem I complex from a photosynthetic organism and a hydrogenase enzyme in the absence of an intervening exogenous electron carrier.... | 06/25/2002 |
| 6338846 | Recombinant baculovirus, construction method thereof and insect pesticidal composition containing the same A recombinant baculovirus, which produces a recombinant polyhedra made up of a baculovirus polyhedrin (PH), a Bacillus thuringiensis crystal protein (CP) and jellyfish Aequorea victoria green fluorescent protein (GFP), is constructed by introducing a tran... | 01/15/2002 |
| 6335185 | Bacteriophage vectors generated by bacteriophage/plasmid recombination The present invention relates to methods for the generation of lambda (λ) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins, methods for the identification of a λ or P1 bacteriophage ... | 01/01/2002 |
| 6319716 | Bovine adenovirus type 3 genome and vector systems derived therefrom The present invention provides the complete nucleotide sequence of a bovine adenovirus. The invention further provides bovine adenovirus vectors and expression systems which can be used, among other things, for insertion of foreign sequences, for provisio... | 11/20/2001 |
| 6312939 | Genetically engineered glutaminase and its use in antiviral and anticancer therapy DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent a... | 11/06/2001 |
| 6303331 | Vertebrate apoptosis gene: compositions and methods The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant ... | 10/16/2001 |
