Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8101412 | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood... | 01/24/2012 |
| 7303912 | Cultures of GFAP nestin cells that differentiate to neurons Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. T... | 12/04/2007 |
| 7294509 | Pre-adipose cell lines This invention relates to new immortalized human pre-adipose cell lines capable of differentiating into adipose cells and methods of obtaing the immortalized cells. In particular, the present invention pertains to immortalized pre-adipocyte cell lines derived from w... | 11/13/2007 |
| 7276352 | Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured... | 10/02/2007 |
| 7250294 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells This invention provides populations of neural progenitor cells and differentiated neurons, obtained by culturing pluripotent cells in special growth cocktails. The technology can be used to produce progenitors that proliferate through at least ˜40 doublings, while ... | 07/31/2007 |
| 7204979 | Generation of hematopoietic cells from multipotent neural stem cells Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing environment can be either ex vivo or in vivo. A mammal's circulatory... | 04/17/2007 |
| 7163695 | Histidine copolymer and methods for using same The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues, having from about 5 to 100% histidine residues, and optionally havin... | 01/16/2007 |
| RE39220 | Peptide-mediated gene transfer A methodology that allows for highly efficient transfer and stable integration of DNA into both established eukaryotic cell lines and primary cells, including non-dividing cells such as human peripheral blood monocytes and macrophages, entails the use of a synthetic... | 08/01/2006 |
| 7070807 | Branched histidine copolymers and methods for using same The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branche... | 07/04/2006 |
| 7041438 | Use of human embryonic stem cells for drug screening and toxicity testing This disclosure provides an improved system for culturing human pluripotent stem (pPS) cells in the absence of feeder cells. The role of the feeder cells can be replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned m... | 05/09/2006 |
| 7018902 | Gate dielectric and method A MOSFET structure with high-k gate dielectric layer and silicon or metal gates, amorphizing treatment of the high-k gate dielectric layer as with a plasma or ion implantation. ... | 03/28/2006 |
| 7001746 | Methods and compositions for the differentiation of human preadipocytes into adipocytes The present invention provides methods and compositions for the consistent and quantitative differentiation of human preadipocytes isolated from adipose tissue into adipocytes bearing biochemical, genetic, and physiological characteristics similar to that observed i... | 02/21/2006 |
| 6969611 | Methods to prepare cells comprising heterologous polyketide synthase expression systems Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the ... | 11/29/2005 |
| 6949381 | Immortalized human skin cell lines and novel serum-free medium useful for the production thereof The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates to novel serum-free media for isolating, producing and maintaining s... | 09/27/2005 |
| 6921665 | Selective antibody targeting of undifferentiated stem cells This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the ... | 07/26/2005 |
| 6777236 | Process for producing a neuronal host cell in vitro comprising regulatory sequences of the β2-subunit of the neuronal nicotinic acetylcholine receptor Several genes encoding subunits of the neuronal nicotinic acetylcholine receptors have been cloned and regulatory elements involved in the transcription of the α:2 and α:7-subunit genes have been described. Yet, the detailed mechanisms governing the neuron-specifi... | 08/17/2004 |
| RE38490 | Method for identifying metastatic sequences The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of at a primary site and incubated for a p... | 04/06/2004 |
| 6642042 | Producing viruses utilizing immortal avian cells The invention features apoptosis-resistant, non-transformant immortalised avian cells, in particular, avian tissues, i.e., other than blood or haematopoietic cells, particularly fibroblasts and epithelial cells, for instance embryos.... | 11/04/2003 |
| 6566136 | Immortalized cell line derived from normal human skin tissues A human keratinocyte cell line immortalized by at least one functional tumor gene of DNA viral origin characterized in that it is: (1) non-tumorigenic, (2) conserves the capacity for differentiation and for the expression of proteins and of enzymes expres... | 05/20/2003 |
| 6555377 | Process for production of mammalian cell lines Described is a process for generating a mammalian cell line from primary mammalian cells, comprising the step of: a) pre-treating a culture of said primary mammalian cells or a suspension thereof with at least one glucocorticoid, b) optional step comprising ob... | 04/29/2003 |
| 6489127 | Methods for identifying anti-cancer drug targets Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tu... | 12/03/2002 |
| 6458593 | Immortalized cell lines and methods of making the same The present invention relates to methods of immortalizing various primary cell cultures, including pituitary cells, neurons, beta islet cells, glial cells, corneal epithelial cells and follicular stellate cells. The primary cells are transfected with a ve... | 10/01/2002 |
| 6423540 | Immortalized human skin cell lines and novel serum-free medium useful for the production thereof The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates to novel serum-free media for isolating, producing and ma... | 07/23/2002 |
| 6417002 | Method for maintenance and selection of episomes A method for obtaining a eukaryotic cell transfected with an episome involves transfecting the cell with the episome under conditions wherein cells survive that are successfully transfected with the episome. The resulting cells express both a first protei... | 07/09/2002 |
| 6358688 | Immortalized human middle ear epithelial cell lines Human middle ear epithelial cell lines permanently transformed by human papilloma viruses have been obtained. These cell lines are useful for the study of gene and protein expression in otitis media and the identification of chemical and biological agents... | 03/19/2002 |
| 6340592 | Human cell lines The invention relates to a method for producing human cell lines and cell and cell-lines produced by such a method. The method comprising the use of precursor or undifferentiated cells treated with an immortalising agent which is susceptible to environmen... | 01/22/2002 |
| 6303331 | Vertebrate apoptosis gene: compositions and methods The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant ... | 10/16/2001 |
| 6255108 | Immortal avian cells The invention features apoptosis-resistant, non-transformant immortalised avian cells, in particular, avian tissues, i.e., other than blood or haematopoietic cells, particularly fibroblasts and epithelial cells, for instance embryos.... | 07/03/2001 |
| 6225122 | Human spinal cord cell lines and methods of use therefor Conditionally-immortalized human spinal cord cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including motoneurons. The cell lines and/or differentiated cells may be used for the development of therapeutic a... | 05/01/2001 |
| 6197585 | Human cell-lines The invention relates to a method for producing human cell lines and cell and cell-lines produced by such a method. The method comprising the use of precursor or undifferentiated cells treated with an immortalising agent which is susceptible to environmen... | 03/06/2001 |
| 6156307 | Immortalization of dendritic cells with v-myc oncogene The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in antigen specific way.... | 12/05/2000 |
| 6071747 | Immortalized cell lines from human adipose tissue, process for preparing same and applications thereof Immortalized cell lines from human adipose tissue, process for preparing same and applications thereof as a study model for the physiopathology of the metabolism and particularly for obesity and diabetes, as tools for developing drugs for the treatment of... | 06/06/2000 |
| 6046050 | Human liver cell line The invention refers to a new human liver cell line which may be used for toxicological, physiological and, in particular, gene therapeutic examinations. Fields of application are molecular biology, medicine and pharmaceutical industry. The new human live... | 04/04/2000 |
| 6030789 | Human conjunctival epithelial cell lines with an extended life span The present invention provides two human conjunctival epithelial cell lines with an extended life span, designated HC0597 and HC0708, and methods for producing such cell lines. These conjunctival cell lines can be cultured as stratified 3-dimensional (3-D... | 02/29/2000 |
| 6001633 | Cells producing recombinant retrovirus An objective of the present invention is to provide a packaging cell for preparing a retrovirus having a high viral titer. The cell producing a recombinant retrovirus is constructed by introducing, the Polyoma virus early region gene together with a recom... | 12/14/1999 |
| 5976807 | Eukaryotic cells stably expressing genes from multiple transfected episomes A method is described for producing recombinant eukaryotic cell lines expressing multiple proteins of interest. Eukaryotic host cells are transfected with (a) a first episome which contains an EBV origin of replication and a first gene encoding a protein ... | 11/02/1999 |
| 5968829 | Human CNS neural stem cells Isolation, characterization, proliferation, differentiation and transplantation of mammalian neural stem cells is disclosed.... | 10/19/1999 |
| 5919997 | Transgenic mice having modified cell-cycle regulation The present invention relates to transgenic mice in which the biological function of at least one cell cycle regulatory proteins of the INK4 family is altered.... | 07/06/1999 |
| 5888498 | Cellular and animal models for diseases associated with mitochondrial defects Cybrid cell lines which have utility as model systems for the study of disorders that are associated with mitochondrial defects are described. The cybrids are constructed by treating immortal cell lines with an agent that irreversibly disables mitochondri... | 03/30/1999 |
| 5885769 | Screening systems Transformed cell lines containing a reporter gene operatively linked to a genetic control element that is responsive to growth factor-stimulated cell proliferation and/or oncogene-mediated neoplastic transformation are provided. Also provided are methods ... | 03/23/1999 |
