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| Number | Title | Issue Date |
| 7311907 | Lentiviral packaging cells Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 12/25/2007 |
| 7294500 | Mosaic infectious bursal disease virus vaccines The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable of growing in a cell that is not derived from a bursa cell, or an inf... | 11/13/2007 |
| 7029665 | Human suppressor tRNA oligonucleotides and methods for use for same Novel synthetic suppressor tRNA have been provided which provide read-through of internal nonsense mutations, or which can site-specifically alter translation of transcribed sequences. Uses of the same are also provided in genetic engineering protocols including gen... | 04/18/2006 |
| 6995010 | Gene transfer method A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of... | 02/07/2006 |
| 6955919 | Lentiviral packaging cells and uses therefor Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 10/18/2005 |
| 6902882 | Methods of monitoring production of gene products and uses thereof This invention relates generally to the field of monitoring production of gene products. In particular, the invention provides methods of monitoring production of a gene product, methods of screening for modulators of production of a gene product, and methods of scr... | 06/07/2005 |
| 6830920 | Rapid generation of recombinant adenoviral vectors The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombina... | 12/14/2004 |
| 6825039 | Plant pyruvate dehydrogenase kinase gene The present invention relates to the isolation, purification, characterization and use of a mitochondrial pyruvate dehydrogenase kinase (PDHK) gene (SEQ ID NO:1) (pYA5; ATCC No 209562) from the Brassicaceae (specifically Arabidopsis thaliana). The inve... | 11/30/2004 |
| 6645766 | Shuttle vectors The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provid... | 11/11/2003 |
| 6485966 | Compositions and methods for helper-free production of recombinant adeno-associated viruses A method for producing recombinant adeno-associated virus in the absence of contaminating helper virus or wild-type virus involves culturing a mammalian host cell containing an rAd/AAV hybrid virus, an AAV rep sequence and an AAV cap sequence under the co... | 11/26/2002 |
| 6485912 | Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACS) in novel gene trapping protocols. Targeted gene trapping by h... | 11/26/2002 |
| 6451304 | Method for retrovirus vector production by separated gag and pol expression The invention provides a system for production of retroviruses which are replication incompetent. In the system, gag and pol retroviral structural proteins are expressed separately by different plasmids in a packaging cell line. Separate gag and pol expre... | 09/17/2002 |
| 6391582 | Shuttle vectors The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provid... | 05/21/2002 |
| 6365150 | Lentiviral packaging cells Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produce... | 04/02/2002 |
| 6306654 | Follicle stimulating hormone-glycosylation analogs Recombinant materials are provided for the production of the -glycoprotein hormone subunit. These muteins have utility as antagonists and in altering pharmacokinetic activity of these hormones.... | 10/23/2001 |
| 6280937 | Shuttle vectors The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provid... | 08/28/2001 |
| 6258595 | Compositions and methods for helper-free production of recombinant adeno-associated viruses A method for producing recombinant adeno-associated virus in the absence of contaminating helper virus or wild-type virus involves culturing a mammalian host cell containing an rAd/AAV hybrid virus, an AAV rep sequence and an AAV cap sequence under the co... | 07/10/2001 |
| 6218185 | Piggybac transposon-based genetic transformation system for insects The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host c... | 04/17/2001 |
| 6211432 | DNA sequences coding for a cinnamoyl COA reductase, and applications thereof in the control of lignin contents in plants The present invention relates to any DNA sequence comprising as a coding region all or part of the nucleotidic sequence coding for a mRNA coding coding for a cinnamoyl CoA reductase (CCR) in lucern and/or corn, or all or part of the nucleotide sequence co... | 04/03/2001 |
| 6156574 | Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACs) in novel gene trapping protocols. Targeted gene trapping by h... | 12/05/2000 |
| 6143566 | Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertion, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. T... | 11/07/2000 |
| 6130090 | Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACs) in novel gene trapping protocols. Targeted gene trapping by h... | 10/10/2000 |
| 6110702 | PSA positive regulating (PSAR) sequences and uses thereof The present invention provides an isolated nucleic acid molecule which is a PSA positive regulatory sequence (PSAR). This molecule has been deposited with the ATCC. In one embodiment of the invention, the molecule comprises a nucleic acid sequence shown i... | 08/29/2000 |
| 5994136 | Method and means for producing high titer, safe, recombinant lentivirus vectors Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the v... | 11/30/1999 |
| 5972708 | Plasmid stabilization A system is described which utilizes a novel system of repressor titration for maintenance of a plasmid useful in gene therapy and production of a recombinant protein. The system utilizes a transformed host cell containing a plasmid including an operator ... | 10/26/1999 |
| 5955365 | Self-assembling polynucleotide delivery system This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of... | 09/21/1999 |
| 5939285 | Method for regulating the expression of a gene in a baculovirus using a retinoic acid receptor binding site and vector therefor A recombinant vector useful for regulating the expression of a gene contred by a baculovirus polyhedrin promoter or P10 promoter, via a sequence forming an RAR-type hormone receptor binding site.... | 08/17/1999 |
| 5922315 | Adenoviruses having altered hexon proteins An adenovirus wherein at least one portion of at least one loop region of the hexon is changed. In one embodiment, the adenovirus, prior to modification, is of a first serotype, and at least a portion of at least one loop region of the hexon is removed an... | 07/13/1999 |
| 5885836 | FLP-mediated gene modification in mammalian cells, and compositions and cells useful therefor A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines... | 03/23/1999 |
| 5783431 | Methods for generating and screening novel metabolic pathways The present invention relates to a novel drug discovery system for generating and screening molecular diversity. The system provides methods for mixing and cloning genetic materials from a plurality of species of organisms in combinatorial gene expression... | 07/21/1998 |
| 5707830 | Autonomous replicaton system for mammalian cells The present invention describes an expression vector useful for transfection of a selected mammalian host cell. The vector includes the following components: an Epstein Barr Virus (EBV) family of repeats; a copy of the EBV Nuclear Antigen-1 (EBNA-1) gene ... | 01/13/1998 |
| 5665590 | Method for isolating and directly cloning genes which encode cell-surface and secreted proteins Methods and DNA cloning vectors are provided for obtaining genes encoding secreted proteins and cell surface proteins.... | 09/09/1997 |
| 5658758 | Polynucleotides encoding cytostatin I A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly ... | 08/19/1997 |
| 5439809 | Non-infectious HIV particles lacking long terminal repeats An immunogenic HIV retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against HIV infection, is produced by genetic engineering. A DNA molecule comprising the HIV genome devoid of long... | 08/08/1995 |
| 5342762 | Fibronectin purification vector Recombinant protein purification vectors and methods for their use are disclosed. The vectors contain a DNA sequence coding for a gelatin binding region of fibronectin. The vectors express a foreign DNA sequence of interest fused to the fibronectin portio... | 08/30/1994 |
| 5340727 | GPIb fragments and recombinant DNA expression vectors Recombinant DNA expression vectors encoding a peptide which inhibits binding of von Willebrand factor to platelet membrane glycoprotein Ib, said vector including a nucleotide sequence encoding the amino acid sequence from HIS1 to LEU610 | 08/23/1994 |
| 5324643 | Method of conferring resistance to retroviral infection In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective vir... | 06/28/1994 |
| 5302517 | Method of controlling the expression of a gene in a cell culture, cell culture vector used in the method and method of making the vector To control the production of a protein product by an animal cell culture, a culture of cells is grown to a density greater than one million cells per milliliter wherein the cells have first and second genes under the control of a single promoter with one ... | 04/12/1994 |
| 5275942 | Mammalian cell-based DNA libraries A recombinant plasmid useful for the production of large-insert, stably maintained, episomes in mammalian cells is disclosed, along with cells, DNA libraries, and methods of using the same. The plasmid comprises a lymphotrophic herpes virus segment (e.g.,... | 01/04/1994 |
| 5270452 | Pure glia maturation factor Pure homogeneous glia maturation factor is disclosed with methods for producing it from neutral sources and by molecular cloning and genetic engineering.... | 12/14/1993 |
