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| Number | Title | Issue Date |
| 7927874 | Method of transferring substance into cell There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell in which the substance desired to be transferred into cells has been ... | 04/19/2011 |
| 7892836 | Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue The capillary gun for delivery of ballistic particles to a target includes an inner capillary tube disposed concentrically within an outer capillary tube with the input end of the inner tube connected to a channel through which a continuous flow of high speed helium... | 02/22/2011 |
| 7422861 | Oligonucleotide transfection screening method Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected pep... | 09/09/2008 |
| 7402435 | Method of transferring a selected molecule into a cell A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around ... | 07/22/2008 |
| 7402573 | Use of nanoparticles for the DNA administration to a target organ The invention relates to the use of DNA-loaded nanoparticles for a transfection of DNA into cells in vitro or in vivo. ... | 07/22/2008 |
| 7366377 | Particle concentration method A method for concentrating particles, including: placing the particles close to and/or on at least one waveguide of a support, and injecting light radiation into the waveguide causing grouping of particles into one or plural clusters on the waveguides. ... | 04/29/2008 |
| 7361508 | Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant Methods for the targeted integration of nucleotide sequences into a plant are provided. Transfer cassettes comprising nucleotide sequences of interest flanked by non-identical recombination sites are used to transform a plant comprising a target site. The target sit... | 04/22/2008 |
| 7358234 | Induction of a protective immune response through microprojectiles coated with a DNA sequence encoding an immunogenic protein The present invention relates to a process for inducing a protective immune response in a mammal against a virus, in which a construct including a promoter and a DNA sequence encoding a protein or peptide producing an immune response against the virus is introduced ... | 04/15/2008 |
| 7344887 | Methods and products for delivering biological molecules to cells using multicomponent nanostructures This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be s... | 03/18/2008 |
| 7335760 | Nucleic acid sequences encoding zinc finger proteins Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants. ... | 02/26/2008 |
| 7332339 | Transferring materials into cells using porous silicon Porous and/or polycrystalline silicon are used in the delivery of substances into cells. The porous and/or polycrystalline silicon can be formed into micropiercers, microneedles and biolistic bullets for penetration of the cell. The control of the pore size and poro... | 02/19/2008 |
| 7304277 | Resonator with adjustable capacitor for medical device An apparatus, system and method of a resonator device with an adjustable capacitor for allowing the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system. The resonator device includes an inductor coil, a... | 12/04/2007 |
| 7279322 | Electrospraying apparatus and method for coating particles An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A s... | 10/09/2007 |
| 7279664 | Resonator for medical device A resonator device including an induction coil, a conductive member positioned adjacent the induction coil, and a dielectric layer between at least a portion of the induction coil and the conductive member to form a capacitor structure. In one embodiment, the conduc... | 10/09/2007 |
| 7261702 | Needleless syringe operating with an impact wave generator through a wall The technical field of the invention is that of needleless syringes used for intradermal, subcutaneous or intramuscular injections of active principle for therapeutic purposes. More particularly, the invention concerns a needleless syringe (10) comprising a p... | 08/28/2007 |
| 7250404 | Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and e... | 07/31/2007 |
| 7244513 | Stain-etched silicon powder The present invention is for a porous silicon powder comprising silicon particles wherein the outermost layers of said particles are porous. The present invention is also directed to a method of making this porous silicon powder using a stain etch method. The presen... | 07/17/2007 |
| 7211143 | Sacrificial template method of fabricating a nanotube Methods of fabricating uniform nanotubes are described in which nanotubes were synthesized as sheaths over nanowire templates, such as using a chemical vapor deposition process. For example, single-crystalline zinc oxide (ZnO) nanowires are utilized as templates ove... | 05/01/2007 |
| 7196321 | Fine pattern forming apparatus and fine pattern inspecting apparatus Disclosed is a fine pattern forming apparatus and a fine pattern inspecting apparatus. In one preferred form, the fine pattern forming apparatus includes a surface irregularity information reading device for detecting a shape signal corresponding to a surface irregu... | 03/27/2007 |
| 7189976 | Method for generating high-speed particle and system for generating high-speed particle The present invention relates to a high-speed particle generating method and so on for generating high-speed particles from a high-speed particle generating target by condensing a pulsed laser beam to a micro-spot on the surface of a high-speed particle generating t... | 03/13/2007 |
| 7176186 | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based on the ability to direct particulate polynucleotides which express an ... | 02/13/2007 |
| 7157439 | HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device com... | 01/02/2007 |
| 7132289 | Method for introducing foreign matters into living cells A method for introducing a foreign matter into a cell, includes the steps of placing a small particle carrying a foreign matter at a part of a cell surface of a living cell, boring a hole in a cell wall and/or a cell membrane by irradiating and treating said part of... | 11/07/2006 |
| 7116430 | Highly-sensitive displacement-measuring optical device The present invention relates to micron-scale displacement measurement devices. A first embodiment is a device that includes a substrate and a rigid structure suspended above the substrate to form a backside cavity. Formed in the rigid structure is a reflective diff... | 10/03/2006 |
| 7115582 | HoxD3 and HoxA3 compositions and methods for improved wound healing The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device com... | 10/03/2006 |
| 7105052 | Ordered array of magnetized nanorods and associated methods An ordered array of magnetized nanorods includes a plurality of metallic nanorods generally cylindrical in shape and including a nickel portion coated with a positively charged polyelectrolyte and a gold portion coated with an alkanethiolate; and a layer of a harden... | 09/12/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7094606 | Use of mixed duplex oligonucleotides to effect localized genetic changes in plants The invention concerns the use of duplex oligonucleotides about 25 to 30 base pairs to introduce site specific genetic alterations in plant cells. The oligonucleotides can be delivered by mechanical (biolistic) systems or by electrpoporation of plant protoplasts. Th... | 08/22/2006 |
| 7078227 | Ready-to-use electroporation cuvette including frozen electrocompetent cells A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is confi... | 07/18/2006 |
| 7068377 | System and method for surface profiling a target object The present invention relates to microinterferometers and the application of such to profile surface geometries. A representative method for profiling a target surface of an object includes: illuminating the target surface with an incident light beam through a phase... | 06/27/2006 |
| 7067285 | Desaturase genes and uses thereof The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be u... | 06/27/2006 |
| 7026166 | Fluorogenic dyes The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule. ... | 04/11/2006 |
| 7022313 | Hydrogel particle formulation New compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle injection techniques. Methods of providing the new compositions are also prov... | 04/04/2006 |
| 7001616 | Microspheres for use in the treatment of cancer The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitiv... | 02/21/2006 |
| 6995008 | Coordinate in vivo gene expression Nucleic acids, including DNA constructs and RNA transcripts, capable of inducing coordinate expression of two to three cistrons upon direct introduction into animal tissues, are bi- or tri-cistronic polynucleotides of this invention include those encoding and co-exp... | 02/07/2006 |
| 6977172 | Method and apparatus for targeting localized electroporation The invention comprises an apparatus and a method of effecting localized electroporation in a relatively small target area and for introducing foreign matter into cellular material in which the target area is located. The cellular material may be in vitro, in ovo or... | 12/20/2005 |
| 6953592 | Water soluble powders and tablets The invention relates to water soluble or water dispersible powders, tablets, or precursors therefor based on a carbohydrate matrix with improved dissolution properties in water. These components are subjected to treatment with a gas so that gas is entrapped therein... | 10/11/2005 |
| 6929950 | Microprojectile delivery system and particulate product The invention relates to a particulate product comprising at least one microprojectile; characterized in that the or at least one of the microprojectiles comprises silicon. The invention also relates to devices and components used in the microprojectile implantation... | 08/16/2005 |
| 6911586 | Garden bean named ‘210104’ A novel garden bean cultivar, designated ‘210104’, is disclosed. The invention relates to the seeds of garden bean cultivar ‘210104’, to the plants of garden bean line ‘210104’ and to methods for producing a bean plant by crossing the cultivar ‘210104... | 06/28/2005 |
| 6875612 | Monocyte-specific particulate delivery vehicle The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be phagocytized. The vector itself, or cells pretreated with the vector, are use... | 04/05/2005 |
