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| Number | Title | Issue Date |
| 7442550 | Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envel... | 10/28/2008 |
| 7432103 | Methods of protein production in cell lines The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins. ... | 10/07/2008 |
| 7407795 | Method for growing on a substrate and novel method for hybridizing different strains of Two different strains of Cordyceps sinensis are placed at two different locations in a medium containing purified rattle snake venom and the two strains are allowed to grow until they meet in a boundary zone where a hybrid strain is formed due to exchange of ... | 08/05/2008 |
| 7402409 | Cell fusion method The invention provides methods for fusing a first cell with a second cell to form a hybrid cell. The methods involve incubating a first parental cell producing a first partner of a fusogenic binding partner pair on its surface with a second parental cell producing a... | 07/22/2008 |
| 7362429 | Opaque additive to block stray light in amorphous fluoropolymer light-guiding flowcells The present invention is directed to the use of a light absorbing wall material to eliminate stray light paths in light-guiding structures, such as those used for HPLC absorbance detection. More specifically, the present invention relates to the use of carbon-doped ... | 04/22/2008 |
| 7351582 | Cell lines The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins. ... | 04/01/2008 |
| 7335470 | Compilations of nucleic acids and arrays and methods of using them In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p... | 02/26/2008 |
| 7253334 | Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells. ... | 08/07/2007 |
| 7247475 | Method for producing monoclonal antibodies An improved method for the production of monoclonal antibodies is disclosed. ... | 07/24/2007 |
| 7223599 | Immortalization of human post-mitotic cells The present invention provides an immortalized human cardiomyocyte cell line. The present invention further provides a method for preparing a human immortalized cell line derived from a post-mitotic primary cell culture. ... | 05/29/2007 |
| 7195926 | Antibodies to a cathepsin C homolog The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression... | 03/27/2007 |
| 7189809 | Scavenger receptors Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases s... | 03/13/2007 |
| 7148040 | Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides popula... | 12/12/2006 |
| 7148332 | High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse... | 12/12/2006 |
| 7135556 | NPC1L1 (NPC3) and methods of use thereof We claim an isolated polypeptide having ability of binding with cholesterol. Said polypeptide is useful for investigating regulation of intestinal cholesterol absorption and cholesterol levels. Also, we claim a composition comprising said polypeptide bound to choles... | 11/14/2006 |
| 7129087 | Oligonucleotide-facilitated coalescence Coalescence of cells or other membrane-bound entities is facilitated by anchoring an outwardly projecting first oligonucleotide in one member and an outwardly projecting second oligonucleotide, complementary to the first, in a second member and incubating under hybr... | 10/31/2006 |
| 7074983 | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 07/11/2006 |
| 7071372 | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells An improved method of nuclear transfer employing long-term cultured somatic cells as the donor cells and enucleated oocytes as the recipient cells to produce dividing cybrids. Such cybrids are useful for developing viable animals clones when nurtured in a suitable h... | 07/04/2006 |
| 7053264 | Nuclear reprogramming using IWSI and related chromatin remodeling ATPases Methods and compositions for dedifferentiating nuclei from somatic cells are provided. Such methods and compositions are useful for facilitating processes such as, for example, cloning and immortalization of cells. ... | 05/30/2006 |
| 7045352 | Converting diploidy to haploidy for genetic diagnosis Detection of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from every chromoso... | 05/16/2006 |
| 7045605 | Modified antibodies to prostate-specific membrane antigen and uses thereof Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or antigen-binding fragments thereof, have been rendered less immunogenic compa... | 05/16/2006 |
| 7029868 | Cell fusion assays using fluorescence resonance energy transfer Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying subst... | 04/18/2006 |
| 7009040 | Cancerous disease modifying antibodies The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the produ... | 03/07/2006 |
| 6979534 | Compositions and methods for detection of antibody binding to cells The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on the surface of the bacteriophage, the first antibody being specific ... | 12/27/2005 |
| 6849451 | Hybrid cells A rapid, simple-to-use method for preparing hybrid cells, applicable to fully differentiate, non-dividing cells, entails bringing at least two different cells into contact under conditions that promote cell fusion and then purifying the resultant hybrid without anti... | 02/01/2005 |
| 6824983 | Method for the mutagenesis of nucleotide sequences in plants algae or fungi The invention relates to a method for the mutagenesis of eucaryotic nucleotide sequences, preferably from plants, algae and/or fungi and a method for the production of genetically modified eucaryotic cells. The subject of the invention is the genetically altered nuc... | 11/30/2004 |
| 6805864 | Type I angiotensin II receptor specific monoclonal antibodies and hybridomas The present invention relates to a novel hybridoma cell line which secretes monoclonal antibodies capable of binding to the AT1 subtype of the Angiotensin II receptor. It also relates to monoclonal antibodies secreted by the hybridoma, which antibodies ma... | 10/19/2004 |
| 6794494 | Cancerous disease modifying antibodies The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the produ... | 09/21/2004 |
| 6783986 | Sucrose phosphate synthetase (SPS), a preparation method and cDNA therefor, and use of the cDNA for modifying SPS expression in plant cells Proteins having the activity of saccharose phosphate synthetase (SPS) and a process for obtaining the same. ... | 08/31/2004 |
| 6753171 | Site-specific cell perforation technique A technique for controlling membrane denaturation reactions other than physical shear force was developed. For example, the present invention provides, a method for causing membrane disruption at a specific site by reacting a stimulus such as light with a compound t... | 06/22/2004 |
| 6740507 | Engineering of living cells for the expression of holo-phycobiliprotein-based constructs Recombinant cells which express a fluorescent holo-phycobiliprotein fusion protein and methods of use are described. The cells comprises a bilin, a recombinant bilin reductase, an apo-phycobiliprotein fusion protein precursor of the fusion protein comprising a corre... | 05/25/2004 |
| 6733761 | Mycobacterial isocitrate lyase gene and uses thereof The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated isocitrate lyase proteins and mutated isocitrate lyase proteins. Add... | 05/11/2004 |
| 6652848 | Dendritic cell hybrids Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic cell hybrids.... | 11/25/2003 |
| 6630327 | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in... | 10/07/2003 |
| 6531646 | Strain manipulation and improvement in the edible seaweed Porphyra A method for the genetic modification and improvement of Porphyra species utilizing protoplast fusion is disclosed. The method of the invention features the use of conchoporangial branch conchocelis for at least one of the sources of protoplasts for proto... | 03/11/2003 |
| 6475794 | Converting diploidy to haploidy for genetic diagnosis Detection of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from eve... | 11/05/2002 |
| 6387698 | MAGE-10 encoding CDNA, the tumor rejection antigen precursor MAGE-10, antibodies specific to the molecule, and uses thereof Isolated cDNA molecules which encode the tumor rejection antigen precursor MAGE-10, the protein itself, antibodies to it, and uses of these are part of the invention.... | 05/14/2002 |
| 6355485 | Electrofusion chamber A new and useful apparatus for producing cell electrofusion is provided. The apparatus comprises: a. a chamber with a substrate disposed therein, b. means for directing the cells to be fused toward one side of the substrate; and c. a device for inducing fusion... | 03/12/2002 |
| 6348576 | Human cornichon molecule The invention provides a human cornichon protein (CORN) and polynucleotides which identify and encode CORN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating ... | 02/19/2002 |
| 6322787 | Induction of an anti-tumor immunity by redirecting tumor cells against antigen-presenting cells According to the invention, there is provided a human or animal cell expressing an antibody directed against a surface antigen on an antigen-presenting cell (APC) and lacking parental tumor-derived immunoglobulin.... | 11/27/2001 |
