Class 435/44 - By desacylation of the substituent in 6-position

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes wherein the product synthesized is prepared by
No. of patents: 32
Last issue date: 08/14/2007

Number	Title	Issue Date
7255872	Method for immobilization of mediator molecules on metallic and ceramic implant materials A mediator molecule is immobilized on the surface of a metallic or ceramic implant material. An anchor molecule (e.g., dialdehyde or cyanogen bromide) having a functional group that covalently binds the mediator molecule is covalently bound to the surface, and the m...	08/14/2007
6927051	Polymer-protein surfactants An enzymatic chemical process comprising the steps of providing a biphasic liquid medium that includes one polar phase and one nonpolar phase in contact with each other, wherein at least one of the phases includes reactants, and adding a polymer-protein surfactant t...	08/09/2005
6770455	Metal-containing ribonucleotide polypeptides The present invention relates to metal-containing ribonucleotide polypeptides (RNP) and processes for their production, their use and medicaments containing ribonucleotide polypeptides or their molecular-biological equivalent structures and/or parts and/or derivativ...	08/03/2004
6503727	Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the...	01/07/2003
6391591	Biotechnological process for preparing N-acetylmannosamine Novel microorganisms, which can be obtained by the following selection method: (a) microorganisms which grow using N-acetylglucosamine as the sole carbon source are cultivated in a customary manner, (b) from the resulting culture, these microorganisms are then...	05/21/2002
6383772	Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic acid (6-APA), may be ...	05/07/2002
6379922	Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a plurality of the biocatalyst-immobilized sheets are located at ...	04/30/2002
6359200	Inbred corn plant 8M116 According to the invention, there is provided an inbred corn plant, designated 8M116. This invention thus relates to the plants and seeds of inbred corn plant 8M116 and to methods for producing a corn plant produced by crossing the inbred plant 8M116 with...	03/19/2002
6180360	Process of producing ଲ-lactam antibiotics applying micro-organisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ...	01/30/2001
6110699	Process for producing 6-amino-penicillanic acid and phenylacetic acid Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the c...	08/29/2000
6033823	Mutated penicillin G acylase genes New mutant ଲ-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G acylase and having an amino acid sequence which differs a...	03/07/2000
5902577	Insulin-secreting cell lines, methods of production and use The invention relates to the field of biology and, in particular, to the field of cellular biology. The invention concerns a novel glucose-sensitive cell line designated ଲ cell line (INS-I) expressing glucokinase and the glucose carrier Glut 2 at le...	05/11/1999
5891703	Mutated penicillin G acylase genes New mutant ଲ-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding for said Penicillin G acylase and having an amino acid sequence which diffe...	04/06/1999
5780260	Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an immobilized enzyme having a specific volume activity of at ...	07/14/1998
5521068	Process for 7-aminodesacetoxycephalosporanic acid The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin acylase from which the product is separated after reaction by...	05/28/1996
5500352	Membrane filtration process for 6-aminopenicillanic acid The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin acylase from which the product is separated after reaction by...	03/19/1996
5457032	Mutated ଲ-lactam acylase genes New mutant ଲ-lactam acylases are provided exhibiting altered substrate specificities. These ଲ-lactam acylases are obtained by expression of a gene encoding said ଲ-lactam acylase and having an amino acid sequence which differs at least in...	10/10/1995
5268271	Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase Synthesis of semi-synthetic monobactamic or ଲ-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/coso...	12/07/1993
5244790	Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same The present invention relates to microorgaisms which produce the aroma and flavor of traditional Korean soybean paste. The present invention also relates to a method for producing the soybean paste which comprises inoculating a pure boiled soybean medium ...	09/14/1993
5215891	Process for preparing penems A process for preparing a compound of formula I: ##STR1## wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, which comprises: hydrolyzing a compound of formula II ##STR2## wherei...	06/01/1993
5079146	Method of protection of the carboxy groups in the chemistry of ଲ-lactam compounds The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of ଲ-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetox...	01/07/1992
4371612	Immobilization of biological material with an acrylonitrile polymer Biological material such as enzymes is immobilized by adsorption or covalent bonding to a micro-porous water-insoluble acrylonitrile polymer containing from 20 μM to 1000 μM of amino groups per gram of the polymer. Covalent bonding may be carried out wi...	02/01/1983
4370414	Process for producing 6-aminopenicillanic acid and 6-aminopenicillanic acid S-oxide A process for producing 6-aminopenicillanic acid and 6-aminopenicillanic acid S-oxide by means of enzymes produced by microbes belonging to Arthrobacter genus, especially Arthrobacter cremorum and Arthrobacter flagellum....	01/25/1983
4267273	Enzyme preparation having affinity for water-immiscible liquids An enzyme preparation is prepared having terminal non-polar groups incorporated therein so that the enzyme preparation has affinity for a water-immiscible liquid. The enzyme preparation can be separated from an aqueous reaction mixture by contacting the m...	05/12/1981
4247643	Preparation of stabilized carrier-bound proteins Stabilized carrier-bound protein is prepared by reacting a protein in aqueous solution with a mercapto group free, water insoluble carrier which contains binding groups which are reactive with the said protein and reacting the resultant protein-containing...	01/27/1981
4246346	Antibiotic and steroid transformation process A method for activating immobilized living microorganisms applied to transformations of steroids, antibiotics and other compounds characterized by the addition of peptone, glucose or a mixture of peptone and glucose to the reaction mixture....	01/20/1981
4113566	Process for preparing 6-aminopenicillanic acid A simple and efficient process for the deacylation of penicillins to 6-aminopenicillanic acid in which an aqueous penicillin solution is rapidly recirculated through a shallow bed comprising particulate immobilized penicillin acylase at 15°-45° C and pH...	09/12/1978
4053360	Enzymatic preparation of 6-D-(-)-଱-amino-଱-(p-hydroxyphenylacetamino)penicillin acid This invention relates to a novel ଱-amino଱-(p-acyloxyphenyl)acetamidopenicillanic acid which is useful as an antibacterial agent, and also to a novel process for the production of 6-D-(-)଱-amino-଱-(p-hydroxyphenylacetamido)pen...	10/11/1977
4048018	Method of carrying out enzyme catalyzed reactions A liquid stream containing the reactants is passed through a bed of enzyme catalyst, made up of enzymes bonded to small, dense particles of carrier or support materials, in a manner which causes the bed to expand or fluidize and a chemical reaction is the...	09/13/1977
4033817	Pressure-driven enzyme-coupled membranes Pressure-driven enzyme-coupled membranes are prepared starting with a membrane filter having pores of appropriate, molecular dimensions and composed of a polymeric matrix, the activation of that matrix (where necessary) under pressure-driven conditions to...	07/05/1977
4001264	Enzyme complexes and their use Novel water-insoluble enzyme complexes are provided which comprise a penicillin acylase enzyme adsorbed on a water-insoluble polymer substrate which is a polymer or copolymer of methacrylic acid and cross-linked with a cross-linking agent selected from gl...	01/04/1977
3953291	Process for preparing 6-aminopenicillanic acid At least one acryloyl monomer is polymerized in an aqueous suspension containing a penicillin amidase-producing microorganism. The acryloyl monomers employed in the present invention include acryloylamide, N,N'-lower alkylene-bis-acryloylamide, bis(acrylo...	04/27/1976

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Class 435/44 - By desacylation of the substituent in 6-position