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| Number | Title | Issue Date |
| 7241588 | Method for producing novel β-lactam antibiotic from protoplast fusion strain The present invention provides a method for producing a novel β-lactam antibiotic from a protoplast fusion strain. The method is to fermentatively culture the protoplast fusion strain of Penicillium chrysogenum and Cephalosporium acremonium. The ferme... | 07/10/2007 |
| 7229784 | Modulation of secondary metabolite production by zinc binuclear cluster proteins Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming ... | 06/12/2007 |
| 7141385 | Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in deflection of a microcantilever having a substrate or an enzyme, respectiv... | 11/28/2006 |
| 7053204 | Global regulator of secondary metabolite biosynthesis and methods of use The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite biosynthetic gene clusters. The invention further provides expression ... | 05/30/2006 |
| 7052913 | Matrices for drug delivery and methods for making and using the same In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-ge... | 05/30/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 6992161 | Water-soluble or water-dispersible graft polymers, their preparation and use Cationic polyurethanes and polyureas formed from (a) at least one diisocyanate or reaction product thereof with one or more compounds containing two or more active hydrogen atoms per molecule, and (b) at least one diol, primary or secondary... | 01/31/2006 |
| 6974675 | Process for identifying and enriching cell-specific target structures This invention relates to a process for identifying and enriching cell-specific target structures, in particular for the identification of cell-specific protein combination patterns on the surface of cells and for enriching such cells. The process comprises depositi... | 12/13/2005 |
| 6967097 | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same The present provides a Rhodotorula phenylalanine lyase polypeptide, polynucleotides that encode the polypeptide, and methods of obtaining and using these products. In particular the polypeptide can be employed for the production of phenylalanine, phenylalanin... | 11/22/2005 |
| 6964865 | Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for β-lactam antibiotic biosynthesis DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthe... | 11/15/2005 |
| 6949356 | Methods for improving secondary metabolite production in fungi The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metaboli... | 09/27/2005 |
| 6946282 | Process for decreasing the reducing sugars content of light steepwater A process for decreasing the reducing sugars content of light steepwater comprising complementary incubation of light steepwater from a corn steeping process having sulfur dioxide (SO2) content at between about 20 ppm and about 220 ppm for at least about ... | 09/20/2005 |
| 6924115 | Process for identifying cell-specific target structures This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on an object which contains cells and/or cell membranes originating from... | 08/02/2005 |
| 6905733 | Irreversible immobilization of enzymes into polyurethane coatings This invention provides a method of irreversibly immobilizing an enzyme into polyurethane coatings. This invention also provides for an enzyme-containing coating having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyu... | 06/14/2005 |
| 6642035 | Synthesis of B-keto esters ଲ-keto esters are prepared by way of a lipase-catalyzed transesterification. The synthetic methodology provides a simple scheme for the synthesis of optically active ଲ-keto esters that are useful building blocks and starting materials for natu... | 11/04/2003 |
| 6518039 | Process for the fermentative production of deacylated cephalosporins The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.... | 02/11/2003 |
| 6503727 | Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the... | 01/07/2003 |
| 6383772 | Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic acid (6-APA), may be ... | 05/07/2002 |
| 6379922 | Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a plurality of the biocatalyst-immobilized sheets are located at ... | 04/30/2002 |
| 6361982 | Regulatory gene for clavulanic acid biosynthesis DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use of DNA in a method for producing clavulanic acid in a host.... | 03/26/2002 |
| 6317795 | Dynamic modification of multimedia content A method and system for manipulating or modifying identifiable objects in a standard broadcast or Internet-based multimedia stream according to a control specification and a content specification. Viewers and/or organizations can independently specify acc... | 11/13/2001 |
| 6287799 | Process for the preparation of aଲ-lactam antibiotic Process for the preparation of a ଲ-lactam antibiotic in which a ଲ-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation agent/ଲ-lactam nucleus of less than 2.5, wi... | 09/11/2001 |
| 6284483 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate The present invention relates to a modified enzyme of a non-heme iron (II) dependent family of oxygenases and oxidases which renders the enzyme dependent on bicarbonate for activity. In a preferred embodiment, the modification is an arginine, lysine, or o... | 09/04/2001 |
| 6258555 | DNA encoding ACV synthetase DNA encoding the gene for the synthetase enzyme capable of generating δ (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenu... | 07/10/2001 |
| 6251655 | Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the PCL gene An isolated DNA encoding phenyl acetyl-CoA-ligase and a process of increasing the production of penicillin G in a strain of Penicillium chrysogenum by transforming the strain with the isolated DNA. Also vectors and host organisms having the isolated DNA.... | 06/26/2001 |
| 6218138 | Synthesis of beta-lactam antibiotics with immobilized penicillin amidase Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase from E. coli covalently immobilized on support particles. T... | 04/17/2001 |
| 6180360 | Process of producing ଲ-lactam antibiotics applying micro-organisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 01/30/2001 |
| 6159706 | Application of enzyme prodrugs as anti-infective agents The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the resistance phenotyp... | 12/12/2000 |
| 6156534 | Synthesis of ଲ-lactam antibacterials using soluble side chain esters and enzyme acylase Disclosed is a process for the synthesis of ଲ-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.... | 12/05/2000 |
| 6121033 | Degradable polyesters, a mixed culture of microorganisms for degrading these polyesters, and methods for making these substances Degradable polyesters useful in packaging, packing, agricultural, biomedical, and other applications are made by reacting amine-protected glutamic acid with diols or epoxy compounds. The polyesters include a thermoplastic main chain aliphatic polyester, a... | 09/19/2000 |
| 6110699 | Process for producing 6-amino-penicillanic acid and phenylacetic acid Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the c... | 08/29/2000 |
| 6100052 | Process for the production of clavulanic acid and/or salts thereof by fermentation controlling soluble phosphate concentration A batch fermentation is carried out continuously or semicontinuously using strain of Streptomyces clavuligerus for the production of clavulanic acid. The fermentation process is carried out with strict control of the soluble phosphate in the medium both a... | 08/08/2000 |
| 6090616 | Microorganism, lactamase enzyme obtained therefrom, and their use A lactamase enzyme having good stability, capable of hydrolysing an enatiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isola... | 07/18/2000 |
| 6020151 | Process for the production of 7-ADCA via expandase activity on penicillin G A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.... | 02/01/2000 |
| 5942411 | Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 08/24/1999 |
| 5922907 | Precursors of ଲ-lactam antibacterials having soluble side chain esters Disclosed is a process for the synthesis of ଲ-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.... | 07/13/1999 |
| 5916762 | Process for the recovery of ampicillin Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is homogeneous at a pH... | 06/29/1999 |
| 5882879 | Method for influencing ଲ-lactam antibiotic production and for isolation of large quantities of ACV synthetase Novel methods and compositions are provided for the enhanced production of ଲ-lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum δ-(L--aminoadipyl)-L-cysteinyl-D-... | 03/16/1999 |
| 5882883 | Process for the production of secondary metabolites The invention relates to an improved process for the production of a secondary metabolite comprising (i) fermentation of a microorganism capable of producing said secondary metabolite, and (ii) recovering said metabolite in substantially pure form. Said m... | 03/16/1999 |
| 5801011 | Process for preparing cephalosporins with penicillin acylase without pH control The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7-amino-cephalosporanic acid, 7-amino-3-deacetoxy-cephalosporanic acid or their derivatives with derivatives of -amino acids in the presence of ... | 09/01/1998 |
