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| Number | Title | Issue Date |
| 8187881 | Methods related to wound healing The invention is directed to methods for the treatment of wounds. Such methods utilize novel compositions, including but not limited to amnion-derived multipotent cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amn... | 05/29/2012 |
| 8153430 | Methods related to surgery The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize nove... | 04/10/2012 |
| 8148153 | Substrate for cell culture, producing method thereof and screening method for cell culture conditions utilizing the same A cell culture substrate having at least one area for culturing a cell on a substrate, characterized in that the culturing area comprises an area releasably holding a biologically active substance having a biological activity to the cell and an area for immobilizing... | 04/03/2012 |
| 7977096 | Stem cell growth media and methods of making and using same The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essentia... | 07/12/2011 |
| 7951593 | Culture medium for gingival fibroblasts The present invention relates to a gingival fibroblast culture medium free of animal serum, comprising an animal cell culture medium, free of animal serum, to which is added: from 0.1 ng/ml to 100 ng/ml bFGF, and/or | 05/31/2011 |
| 7754486 | Culture medium named MV06 for both endothelial and myocardiac cells A culture medium named MV06 enabling growth in vitro of both endothelial progenitor and myocardiac progenitor cells, composed of: Iscove's Modified Dubellco's Medium, Fetal calf serum, Horse serum, L-Glutamin (200 mM (100×)) Penicillin (10000 u/mL)/Streptomycin (10... | 07/13/2010 |
| 7514261 | Platelet-derived growth factor protection of cardiac myocardium The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging. ... | 04/07/2009 |
| 7442397 | PEGylated fibrinogen-based biomatrix The invention involves methods and materials related to fibrin-based biomatrices. ... | 10/28/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7344884 | Peptides promoting cell adherence, growth and secretion The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in large quantity by such means as chemical synthesis or recombinant DNA ... | 03/18/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7329726 | Physiologically active peptides A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in... | 02/12/2008 |
| 7326570 | Induction of tubular morphogenesis using pleiotrophin Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are methods of using an active epithelial growth factor having the capability... | 02/05/2008 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7300794 | Accelerated culture system for intestinal epithelial cell monolayers The present invention provides a unique medium for the cultivation of intestinal cell lines. The medium allows for the development of a highly differentiated intestinal epithelial cell monolayer in a much shorter period of time than currently possible without the ai... | 11/27/2007 |
| 7252995 | Method of generating neurons from stem cells and medium for culturing stem cells The present invention relates to a method of generating neurons from stem cells which comprises culturing neurons in a medium and culturing the stem cells in the resultant mixture. The present invention also relates to a medium for culturing stem cells prepared by c... | 08/07/2007 |
| 7232893 | Method of manufacturing a stellate cell death factor The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocyt... | 06/19/2007 |
| 7229827 | Method for differentiating mesenchymal stem cells into neural cells A method for differentiating mesenchymal stem cells of bone marrow into neural cells comprises culturing the mesenchymal stem cells in a medium containing epidermal growth factor(EGF), basic fibroblast growth factor(bFGF) and hepatocyte growth factor(HGF), and the n... | 06/12/2007 |
| 7220538 | Composition for maintaining organ and cell viability The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs suc... | 05/22/2007 |
| 7202080 | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway The subject invention comprises culture methods for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway. It also concerns the endocrine hormones that can be produced by such cultures, and the use of the transdifferentiated cel... | 04/10/2007 |
| 7192768 | Synchronization of the cytoplasmatic and the nuclear maturation of oocytes The present invention relates to a method for in vitro maturation of oocytes comprising the steps of: (a) culturing one or more GV oocytes in a culture medium, the culture medium comprising a nuclear maturation inhibiting substance and comprising one or... | 03/20/2007 |
| 7169610 | Serum-free media for chondrocytes and methods of use thereof The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoids problems inherent in the use of serum-containing media. The defined media comprise platelet-derived growth factor (PD... | 01/30/2007 |
| 7145057 | Chimeric bird from embryonic stem cells Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably int... | 12/05/2006 |
| 7132288 | Medium for culturing tumor cells Disclosed is a medium for cultivating tumor cells, comprising the following constituents, as comprised for example in the medium RPMI 1640: (a) fetal calf serum (FCS), (b) penicillin-streptomycin, (c) L-glutamine, (d) transferrin, (e) insulin, (f) human epidermal gr... | 11/07/2006 |
| 7132287 | Method for neural stem cell differentiation using 5HT-1A agonists The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neura... | 11/07/2006 |
| 7132286 | Method for neural stem cell differentiation using valproate The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural ... | 11/07/2006 |
| 7132279 | Epidermal melanocyte culture formulations The present invention provides methods and compositions for providing graft recipients with epidermal melanocytes. Specifically, the methods and compositions of the invention provide for populations of epidermal melanocytes that may be isolated from a patient and cu... | 11/07/2006 |
| 7129086 | Human marrow stromal cell lines which sustain hematopoiesis Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned by exposure to a human stromal cell line. Preferred human stromal cel... | 10/31/2006 |
| 7122340 | Regulatory T cells; methods Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described. ... | 10/17/2006 |
| 7112437 | Methods of culturing embryonic stem cells and controlled differentiation The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic di... | 09/26/2006 |
| 7109032 | Serum-free medium for mesenchymal stem cells Serum-free media for growth and proliferation of chondrocytes and mesenchymal stem cells in culture are provided. A serum-free medium for growth of chondrocytes includes a serum-free composition comprising FGF-2, linoleic acid, ascorbic acid, B-mercaptoethanol, tran... | 09/19/2006 |
| 7078313 | Method for fabricating an integrated semiconductor circuit to prevent formation of voids Recesses between gate layer stacks are filled with a first electrically insulating material. Cavities or voids are opened up during the removal of a portion of the first insulating material. These voids are filled during the application of a conductive layer and can... | 07/18/2006 |
| 7056503 | Enclosures housing cell-coated supports for treating tumors The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferr... | 06/06/2006 |
| 7045353 | Directed differentiation of human embryonic cells Methods are described for mapping a pathway of differentiation of a population of embryonic cells which includes exposing the cells to an exogenous factor and measuring gene expression products that are characteristic of a particular cell type or lineage. Directing ... | 05/16/2006 |
| 7041506 | Peptides promoting cell adherence, growth and secretion The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in large quantity by such means as chemical synthesis or recombinant DNA ... | 05/09/2006 |
| 7037721 | Protein-free defined media for the growth of normal human keratinocytes Improvements are made to a novel media that replace the requirement for all protein growth factors by the addition to the medium of physiological concentrations of retinyl acetate. The media are serum-free, companion cell or feeder layer-free and organotypic, matrix... | 05/02/2006 |
| 7029915 | Method for differentiating rat hepatic stem cells to insulin-producing cells Highly purified hepatic stem cells are trans-differentiated into pancreatic endocrine hormone-producing cells by culturing them in vitro in a medium containing high levels of glucose. These trans-differentiated cells express insulin, glucagon, and pancreatic polypep... | 04/18/2006 |
| 7022520 | Cell culture media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells. ... | 04/04/2006 |
| 6998266 | Active retinoic acid-free culture medium for avian totipotent embryonic stem cells A culture medium for avian embryonic cells and an avian cell culture medium is disclosed. The culture medium is characterized in that it has elements complementary to avian embryonic cells. The complementary elements include insulin-like growth factors and stem cell... | 02/14/2006 |
| 6949382 | Cell culture media containing N-acetyl-L-cysteine and uses thereof The present invention provides cell culture media and methods useful for determining levels of intracellular function of glutathione or cysteine and for providing biochemical analysis of antioxidant function in human lymphocytes. ... | 09/27/2005 |
