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| Number | Title | Issue Date |
| 7318910 | Chemical dosimeter A chemical dosimeter comprising: a chamber defined by a heat resistant mesh; and a quantity of an adsorbent contained within the chamber; the arrangement being such that gas may diffuse into the chamber through the heat resistant mesh so that chemicals in the gas ma... | 01/15/2008 |
| 7312065 | of European origin and vaccines, diagnostic agents and methods of use thereof The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method ... | 12/25/2007 |
| 7235391 | Formulation of adenovirus for gene therapy The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired ... | 06/26/2007 |
| 7198947 | Production of functional proteins: balance of shear stress and gravity The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a... | 04/03/2007 |
| 7125706 | Method for the production and purification of adenoviral vectors The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for imp... | 10/24/2006 |
| 7105304 | Pressure-based mobility shift assays Methods for chromatographically separating materials, including the separation of materials in kinase or phosphatase assays, in microfluidic devices under positive or negative fluid pressure. Devices and integrated systems for performing chromatographic separations ... | 09/12/2006 |
| 7101719 | Support and method for cell based assays Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different po... | 09/05/2006 |
| 7071005 | Method and device for concentrating selected groups of microorganisms A method and device are described to concentrate target organisms from a mixture of organisms. Beads (1) made of material such as nylon, polystyrene or glass are coated with antibodies of specific microorganisms. The beads (1) are contained in an enclo... | 07/04/2006 |
| 7045363 | Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide A nucleic acid-bound polypeptide produced by binding a nucleic acid to a polypeptide, a method of producing the nucleic acid-bound polypeptide, and applications of the nucleic acid-bound polypeptide, including immunoassays for an antigen or antibody, such as an aggl... | 05/16/2006 |
| 6951752 | Method for large scale production of virus antigen The present invention provides improved methods of production of viral antigen on a culture of adherent cells bound to a microcarrier, wherein the methods provide for increased viral antigen yield per culture medium volume. The invention is also directed to a cell c... | 10/04/2005 |
| 6911201 | Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationa... | 06/28/2005 |
| 6864084 | Bioreactor and method for fluidly suspending a product A method for floating at least one substance for growing a tissue part in a bioreactor. The method includes providing at least one substance consisting of one of a tissue part, a scaffold having cells deposited thereon, and a scaffold including a tissue part thereon... | 03/08/2005 |
| 6858146 | Artificial liver apparatus and method Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes (23) which are either unattached or attached to inert carriers and suspended in a cell culture medium whic... | 02/22/2005 |
| 6783983 | Methods for cultivating cells and propagating viruses This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses. ... | 08/31/2004 |
| 6737074 | Methods of separating cells, transplanting cells and engineering tissue using fibrin microbeads The present invention provides fibrin microbeads that are biologically active and comprise extensively cross-linked fibrin(ogen), and a method for preparing the fibrin microbeads. The present invention also provides a composition comprising cells bound to the fibrin... | 05/18/2004 |
| 6730498 | Production of functional proteins: balance of shear stress and gravity The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a... | 05/04/2004 |
| 6688041 | Pigment concentrates for coloring seeds The present invention relates to the use of a pigment form or pigment concentrate comprising of an organic pigment, and optionally an inorganic filler and/or an organic additive for coloring of seeds. Seeds colored by the dry pigment forms or pigment conc... | 02/10/2004 |
| 6660509 | Methods and devices for remediation and fermentation Abstract of the Invention The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support com... | 12/09/2003 |
| 6632658 | Bioreactor and method for fluidly suspending a product The method for the holding in flotation of a substance such as a tissue part in a bioreactor (61) is characterized in that the substance (73) is acted upon with a fluid; and in that the flow of the fluid acts counter to gravity in such a manner that the s... | 10/14/2003 |
| 6562620 | Medium to promote islet cell survival The present invention relates to a medium for promoting the survival of islet cells, which comprises one or more growth factors in combination with FK506 in amounts having an anti-apoptotic effect on islet cells in a physiologically acceptable culture med... | 05/13/2003 |
| 6503731 | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII for binding cells Fibrin microbeads are prepared containing extensively cross-linked fibrin (ogen) without using glutaraldehyde. The fibrin microbeads are preferably prepared by containing an aqueous solution containing fibrinogen, thrombin and Factor XIII with an oil heat... | 01/07/2003 |
| 6432712 | Transplantable recellularized and reendothelialized vascular tissue graft The invention provides a device and process for recellularizing essentially acellular or devitalized tissue grafts, including for example essentially acellular or devitalized vascular tissue grafts, derived from human or animal sources, or as constructed ... | 08/13/2002 |
| 6426214 | Cell encapsulating device containing a cell displacing core for maintaining cell viability Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds th... | 07/30/2002 |
| 6338942 | Selective expansion of target cell populations Methods and systems are provided for the selective expansion of target cell populations, and methods of treating patients with cell populations and products.... | 01/15/2002 |
| 6303298 | Two-step method of DNA amplification for MALDI-TOF measurement The invention referres to a method for the preparation and selective replication of deoxyribonucleic acid (DNA) from biomaterial using PCR (polymerase chain reaction) for the analysis in time-of-flight mass spectrometers (TOF) with matrix-assisted laser d... | 10/16/2001 |
| 6261558 | Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization abili... | 07/17/2001 |
| 6251673 | Method for manufacturing an implant consisting of a carrier material containing medically active agents The invention concerns an implant consisting of a carrier material containing medical substances such as pharmaceuticals, antibiotics, cytotstatic agents, hormones or the like made out of organic matter, preferably of a biological tissue of human, animal ... | 06/26/2001 |
| 6214618 | Microcarrier beads having a styrene copolymer core and a covalently linked tri-methylamine exterior There is provided a method of making microcarrier beads having the steps of forming a bead made of a lightly crosslinked styrene copolymer core and also having functional groups on the surface of the bead and washing the microcarrier beads with basic and ... | 04/10/2001 |
| 6194210 | Hepatitis A virus culture process A microcarrier based process to produce viral vaccines, of which one example is hepatitis A virus (HAV), is composed of an aggregated microcarrier system of glass coated polystyrene microcarriers and MRC-5 cells which creates a stable environment for the ... | 02/27/2001 |
| 6168944 | Methods for cultivating cells and propagating viruses This invention relates to methods for the cultivating cells, and in particular to methods for propagating recombinant viruses for gene therapy.... | 01/02/2001 |
| 6146891 | Methods for cultivating cells and propagating viruses This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses.... | 11/14/2000 |
| 6107067 | Porous, non-macroporous, inorganic oxide carrier body for immobilizing microorganisms for bioremediation A porous inorganic oxide carrier body for immobilizing living cells is prepared from inorganic oxide particles such as clay particles. The particles have an average particle size of from 0.01 to 20 microns, and the carrier body has a total pore volume of ... | 08/22/2000 |
| 6001642 | Bioreactor and cell culturing processes using the bioreactor A bioreactor and cell culturing method using the bioreactor have been developed to enhance cell production and growth and decrease the shear forces on the cells and multicellular aggregates. The bioreactor contains a dome-shaped culture vessel having wall... | 12/14/1999 |
| 5994134 | Viral production process The present invention is directed to a method of producing recombinant viral vectors at high titers incorporating a variety of important advancements over the art. The method of the present invention incorporates multiple features which provide enhanced p... | 11/30/1999 |
| 5980888 | Keratinocytes attached to microcarriers for treatment of skin wounds Epithelial cells are attached to microcarriers to form a transplantation material for treatment of skin wounds. Preferably, keratinocyte-covered microcarriers are prepared using microcarriers having a diameter of 50 to 500 μm, and obtaining a coverage of... | 11/09/1999 |
| 5980889 | Cell encapsulating device containing a cell displacing core for maintaining cell viability Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds th... | 11/09/1999 |
| 5925567 | Selective expansion of target cell populations A method is provided for selective expansion of a predetermined target population of cells, including (a) introducing a starting sample of cells into a growth medium; (b) causing cells of the predetermined target cell population to divide; and (c) concurr... | 07/20/1999 |
| 5906940 | Culturing cells on macroporous glass carriers coated with gelatin, extracellular matrix protein and stromal cells Stem cells or other organ-function cells are cultivated in a fluidized bed system on macroporous glass carrier bodies treated with a structure protein such as gelatin and an extracellular matrix protein such as fibronectin, and coated with a stroma cell l... | 05/25/1999 |
| 5885823 | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents A method for large scale cultivation and attenuation of L. intracellularis bacteria by inoculating cells with L. intracellularis bacteria to infect the cells, incubating the infected cells in a reduced oxygen concentration and maintaining the infected cel... | 03/23/1999 |
| 5858747 | Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers Methods and compositions are provided for controlling cell distribution within an implantable bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth ... | 01/12/1999 |
