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| Number | Title | Issue Date |
| 8158381 | Methods for integrated tissue processing and staining Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate staining of the sectioned tissue is not required. The method may be used wi... | 04/17/2012 |
| 8062861 | Tissue sample preprocessing methods and devices To preprocess a tissue sample, a first permeable mesh membrane is tautly stretched out over the tissue sample and overlaid on top of a flat surface. This covering sandwiches and secures the tissue sample in between the first permeable mesh membrane and the flat surf... | 11/22/2011 |
| 7767414 | Optical imaging of molecular characteristics of biological specimen Imaging specimen such as biological tissue is facilitated. According to an example embodiment of the present invention, a relatively thin, surface portion of a specimen is stained and imaged. The thin portion is removed, exposing a new portion of the specimen. The n... | 08/03/2010 |
| 7622276 | Methods for processing biological tissue A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and ... | 11/24/2009 |
| 7449306 | Systems and methods for screening pharmaceutical chemicals A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A meth... | 11/11/2008 |
| 7449307 | Raised surface assay plate The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimenta... | 11/11/2008 |
| 7429466 | Methods and arrays for detecting biological molecules Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a second support immobilized with one or more of ligands; contacting the ... | 09/30/2008 |
| 7405056 | Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation ... | 07/29/2008 |
| 7374907 | System and method for automatically processing tissue samples An apparatus and method for producing tissue slides is disclosed. The apparatus includes a holding assembly for manipulating the sample block, a blade assembly for preparing a thin section from the sample block, and a transfer roller mechanism for transferring the t... | 05/20/2008 |
| 7368132 | Glyoxal/zinc fixative This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention comprises glyoxal (pyruvate aldehyde) and zinc sulfate and permits sta... | 05/06/2008 |
| 7358063 | Method of detecting PS2V A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following proced... | 04/15/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7354730 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 04/08/2008 |
| 7297500 | Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 11/20/2007 |
| 7287388 | Cryostat having an integrated staining station A cryostat (1) having a sealable housing (2) is described. The housing (2) encloses a coolable cryostat chamber (3), and a refrigeration device (4), a control system (5) and a power supply (6) are provided for cooling... | 10/30/2007 |
| 7280866 | Non-invasive screening of skin diseases by visible/near-infrared spectroscopy A non-invasive tool for skin disease diagnosis would be a useful clinical adjunct. The purpose of this study was to determine whether visible/near-infrared spectroscopy can be used to non-invasively characterize skin diseases. In-vivo visible- and near-infrared spec... | 10/09/2007 |
| 7273720 | Rapid tissue processing method and apparatus A rapid tissue processing method and apparatus including the steps of fixation, dehydration, clearing, and impregnation. The preferred method is performed in a processing unit that employs alternating microwave and ohmic energy to heat the process solution and tissu... | 09/25/2007 |
| 7267947 | Array-based detection of genetic alterations associated with disease The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. ... | 09/11/2007 |
| RE39760 | Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/humans chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fr... | 08/07/2007 |
| 7237392 | System for preparing cutaneous tissue samples for oncological histology study and diagnosis A method and apparatus for preparing tissue specimens for histological study utilizing two connectable sections each with hollowed cylinders for receiving first and second buttons, each button including planar disc and cylindrical stem portions, such that the stem p... | 07/03/2007 |
| 7238488 | Therapeutic and diagnostic applications of perlecan domain I splice variants A method of producing antibodies comprising the step of encoding a peptide sequence from a Domain I perlecan splice variant, wherein the peptide sequence is used to produce anti-peptide antibodies. ... | 07/03/2007 |
| 7235400 | Laminated microarray interface device A device for forming a low volume reaction chamber on a substrate such as a microarray slide and its method of use is disclosed. The reaction chamber forming device has an adhesive laminate design that permits it to be manufactured as a disposable device. A preferre... | 06/26/2007 |
| 7235140 | Method for cleaning tissue processing molds The present invention is directed to a cleaning system and methods for cleaning tissue embedding molds. The cleaning system includes a cleaning vessel that holds a cleaning solution. The tissue processing molds are supported by a basket receptacle which is placed in... | 06/26/2007 |
| 7234308 | Cold mold A metallic, reusable mold with one or more wells. The mold is kept within a cryostat at low temperature. The mold is removed from the cryostat and a tissue specimen is placed into a well within the mold. An embedding medium is added to the well around the tissue spe... | 06/26/2007 |
| 7236815 | Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy Fluorescence spectral data acquired from tissues in vivo or in vitro is processed in accordance with a multivariate statistical method to achieve the ability to probabilistically classify tissue in a diagnostically useful manner, such as by histopathological classif... | 06/26/2007 |
| 7223363 | Method and system for microfluidic interfacing to arrays A method and system for providing a fluidic interface to slides bearing microarrays of biomolecules or other samples immobilized thereon to perform a variety of chemical reactions or processing steps on the slide. An interface device seals against the slide to form ... | 05/29/2007 |
| 7195885 | Hepatitis C virus assays The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high throughput screening that quantifies both the amount of HCV RNA replica... | 03/27/2007 |
| 7172739 | Protein fractionation A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or chemical properties; (b) contacting the fluid with at least two individual p... | 02/06/2007 |
| 7163823 | DNA hybridization device and method An apparatus and method for DNA hybridization is provided. The apparatus and method work in conjunction with a substrate comprising an upper surface having probes. The apparatus may comprise a material which abuts the substrate, with at least a portion of the materi... | 01/16/2007 |
| 7156814 | Apparatus and method for harvesting and handling tissue samples for biopsy analysis A sectional cassette (10) for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping supporting material (A′) that can withstand tissue preparatio... | 01/02/2007 |
| 7148332 | High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse... | 12/12/2006 |
| 7139602 | Shape analysis of surfaces A method and apparatus are provided to map the shape or thickness of a surface. Thickness estimates across a distance are received, and Fourier analysis is performed to generate Fourier amplitude coefficients and phase values for a number of frequency components. Li... | 11/21/2006 |
| 7128903 | Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same A pharmaceutical preparation useful for treating a skin or mucous membrane lesion is provided. The pharmaceutical preparation including, as active ingredients, a therapeutically effective amount of trichloroacetic acid and hydrochloric acid, or trichloroacetic acid ... | 10/31/2006 |
| 7122322 | Endometriosis-specific secretory protein A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated... | 10/17/2006 |
| 7118853 | Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokera... | 10/10/2006 |
| 7115386 | Device and method for carrying out immunological marking techniques for thin-sectioned tissue The invention relates to a device and a method for carrying out in an optimized and automated manner immunological marking techniques for thin-sectioned tissue (2b). A support plate (1) which can be automatically moved by means of a computer-con... | 10/03/2006 |
| 7090974 | Ultrasound-mediated high-speed biological reaction and tissue processing Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used and the sample or tissue receives 0.1–200 W/cm2 of ultr... | 08/15/2006 |
| 7074903 | Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to TRACP 5b can be obtained by cell fusion using as antigens TRACP 5b puri... | 07/11/2006 |
| 7070950 | Recipient block and method for preparation thereof Disclosed is a recipient block for arraying a certain tissue sample into a desired position on a tissue microarray slide, comprising(a) an additive and (b) a wax. The present invention also discloses a method of preparing a recipient block, including (1) preparing a... | 07/04/2006 |
| 7070951 | Dewaxing kit for immunostaining tissue specimens Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specim... | 07/04/2006 |
