Class 435/40.5 - Involving fixed or stabilized, nonliving microorganism, cell, or tissue (e.g., processes of staining, stabilizing, dehydrating, etc.; compositions used therefore, etc.)

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject where the material to be tested contains fixed or
No. of patents: 427
Last issue date: 04/17/2012

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Number	Title	Issue Date
8158380	Imaging agents for protein misfolding Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styry...	04/17/2012
8148081	Method for detecting microorganisms on a membrane The present invention relates to a method using a composition for permeabilizing microorganism walls for counting and detecting in a targeted manner the microorganisms on a membrane. The invention also relates to a kit and to probes that are suitable for carrying ou...	04/03/2012
8114625	Method for cell analysis The invention describes a method for cell analysis in which the cells to be analyzed are adhesively applied to a slide and stained with a first stain. A first digital image is then taken and stored of the cells applied to the slide and stained. After the first digit...	02/14/2012
7998700	Use of a composition which regulates oxidation/reduction reactions intracellularly and/or extracellulary in a staining or sorting process Staining mixtures comprising viable spermatozoa, a composition which regulates oxidation/reduction reactions intracellularly or extracellularly, and a DNA selective dye are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduri...	08/16/2011
7960138	Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components...	06/14/2011
7927830	Modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a...	04/19/2011
7915007	Fixative for fixing biological materials A fixative for fixing biological materials contains a depot agent, preferably a polyamine and especially hexamethylenetetramine, which reacts chemically with positively charged ions, especially H+ from an acid, while forming a fixative, where the fixative is an alde...	03/29/2011
7883864	Method of treating biological tissue by microwave-irradiation A method of efficiently removing or fixing donor cells from a native tissue of mammalian origin comprises immersing the tissue in a treating solution, and irradiating the tissue with microwave while maintaining the temperature thereof in the range between 0° C. and...	02/08/2011
7871791	Biofilm preparation using potassium permanganate A method for preparing a biofilm includes the steps of rinsing the biofilm. There is the step of staining the biofilm with potassium permanganate and water. ...	01/18/2011
7781187	Fluorescent dyes Fluorescent dyes useful for detecting a target material in biological assays an electron donating moiety which is linked by a conjugated π-electron bridge to an electron accepting moiety. The π-electron bridge includes at least one carbocyclic ring structure or he...	08/24/2010
7670798	Automated method and reagent therefor assaying body fluid samples such as cerebrospinal fluid (CSF) The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid...	03/02/2010
7670799	Method for making 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine (TCPP) solution and composition comprising TCPP Presented is a method of solubilizing TCPP, as well as a composition comprising TCPP solubilized by this method. ...	03/02/2010
7666620	Rapid tissue processing system A method for processing a biological tissue specimen using either manual or automated processing. The tissue specimen is sequentially contacted with components of a reagent system in the presence of increased temperature and/or agitation and in the absence of exogen...	02/23/2010
7645594	Method of preparing assay sample for discriminating bacteria by flow cytometer A method of staining bacteria comprises: working a polymethine dye on a sample in the presence of a substance capable of reducing nitrite ions to stain bacteria in the sample. A method of detecting bacteria comprises the following steps of: (1) working a polymethine...	01/12/2010
7611863	Selective staining of biomembranes using voltage-sensitive dyes The present invention relates to a method for staining membranes, in particular, a method for selective staining of cells using voltage-sensitive dyes. ...	11/03/2009
7541161	Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in ...	06/02/2009
7445910	Method for enumerating mammalian cell micronuclei with an emphasis on differentially staining micronuclei and the chromatin of dead and dying cells The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish th...	11/04/2008
7435383	Automated tissue staining system and reagent container An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper w...	10/14/2008
7429466	Methods and arrays for detecting biological molecules Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a second support immobilized with one or more of ligands; contacting the ...	09/30/2008
7429465	Process for analyzing tear fluid The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezi...	09/30/2008
7427502	Methods for identifying stem cells based on nuclear morphotypes Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specific...	09/23/2008
7425427	Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the sta...	09/16/2008
7422869	Method for diagnosing infectious diseases A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the presence of binding of the microorganism by an antibody in the test sampl...	09/09/2008
7421105	Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in solvent containing a water-miscible organic solvent, and mounting the sta...	09/02/2008
7413872	Device for preparing specimens for a cryo-electron microscope The invention relates to a device for preparing specimens for a cryo-electron microscope, comprising an environmental chamber, a holder for a sample or a carrier, and at least one blotting element to which a medium for absorbing liquid is or can be attached, both di...	08/19/2008
7405056	Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation ...	07/29/2008
7405072	Acoustic radiation for ejecting and monitoring pathogenic fluids The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-c...	07/29/2008
7390630	Method of identifying a compound that selectively inhibits cytokine-stimulated T cell induced production of TNF-alpha by monocytes A method of identifying a compound with efficacy in the treatment of chronic inflammatory disease by testing the compound for an ability to selectively inhibit the ability of Tck cells to induce pro-inflammatory cytokine release from a monocyte is disclos...	06/24/2008
7384764	Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components...	06/10/2008
7371518	Universal collection medium This invention provides a novel universal collection medium for cell collection. The medium allows for the first time the ability to perform cytology and direct molecular analysis on cells preserved in a single sample. This invention also provides novel methods for ...	05/13/2008
7368253	Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the stage of TSE infection and distinguish it from other conditions whic...	05/06/2008
7368132	Glyoxal/zinc fixative This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention comprises glyoxal (pyruvate aldehyde) and zinc sulfate and permits sta...	05/06/2008
7364868	Krüppel-like transcriptional factor KLF4/GKLF and uses thereof The present invention proivdes methods of identifying new carcinoma oncogenes or analyzing functions of known carcinoma oncogenes by transformation of RK3E cells. Also provided are methods of using nuclear localization of Krüppel-like factor 4 (KLF4, or termed Gut-...	04/29/2008
7361478	High-throughput screen for identifying selective persistent sodium channels channel blockers A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method...	04/22/2008
7361462	Method for efficiently determining a DNA strand break The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors accomplished the present invention by providing a method for detectin...	04/22/2008
7354773	Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such sample preparation can be eliminated, leading to a process that readily l...	04/08/2008
7351546	Flow cytometric, whole blood dendritic cell immune function assay The invention provides a flow cytometric method for measuring dendritic cell function in whole blood, comprising: (a) contacting a whole blood sample with a dendritic cell activator; (b) adding to the sample a plurality of dendritic cell-distinguishing antibodies an...	04/01/2008
7348742	Lighting fixture with synchronizable optical filter wheel and related method A method of making an optical filter wheel of a device synchronizable with an internal, rotatable virtual reference wheel, created in a memory of a motor controller of the device, is disclosed. The method includes a single trigger event that initializes rotation of ...	03/25/2008
7344842	Prion test The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disease in humans. The invention provides use of guanidine thiocyanate (gdnSCN) or a functional equivalent thereof for t...	03/18/2008
7332295	Multidimensional leukocyte differential analysis This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells, including the quantification of each subpopulation in terms of cells pe...	02/19/2008

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Class 435/40.5 - Involving fixed or stabilized, nonliving microorganism, cell, or tissue (e.g., processes of staining, stabilizing, dehydrating, etc.; compositions used therefore, etc.)