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| Number | Title | Issue Date |
| 8187800 | Methods for selecting active agents for cancer treatment The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including a... | 05/29/2012 |
| 8187802 | Cell lines useful for assessing modulation of autophagy Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimula... | 05/29/2012 |
| 8187801 | Methods and kits to detect and monitor ovarian cancer and preeclampsia The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to immune cells. The level of MUC16 bound to immune cells can by itself b... | 05/29/2012 |
| 8182983 | Method for determining immune system affecting compounds The present invention relates to a method for increasing efficacy and/or possibility of therapeutic treatment of cancer, wherein any dys-regulatory mechanism, including inducing factor/s, of the production of immunoregulatory substances, including one or more cytoki... | 05/22/2012 |
| 8178290 | Solid support The present invention provides a solid support for performing steps of isolation of cell or extraction and purification of nucleic acid, safely, easily, efficiently, and with high yield in the genetic test for investigating the presence of pathogenic bacterial infec... | 05/15/2012 |
| 8173359 | Methods and apparatus and assays of bacterial spores A sample of unknown bacterial spores is added to a test strip. The sample of unknown bacterial spores is drawn to a first sample region on the test strip by capillary action. Species-specific antibodies are bound to the sample when the unknown bacterial spores match... | 05/08/2012 |
| 8173361 | Method of determining metabolism of a test agent A method for detecting one or more metabolites of a test agent in a tissue including: A) incubating a test agent and an enzyme within a three-dimensional structure comprising a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer s... | 05/08/2012 |
| 8173360 | Cell death inhibitor The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, trau... | 05/08/2012 |
| 8163492 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 04/24/2012 |
| 8163472 | Dry analytical element capable of reducing influence of hemolysis for body fluid component measurement It is an object of the present invention to reduce influence of hemolysis in a dry analytical element used for measurement of components in a body fluid sample such as blood. The present invention provides a method for producing a dry analytical element for body flu... | 04/24/2012 |
| 8163473 | Method for using DNA repair capacity as a biomarker of breast cancer risk in women The present invention presents a method for using DNA repair capacity (DRC) as a blood biomarker to calculate the risk of a female subject developing breast cancer obtained from a blood sample by using a luciferase reporter gene method that permits calculating a per... | 04/24/2012 |
| 8163471 | Reagent for sample analysis, kit for sample analysis and method for sample analysis A reagent for measuring basophils and/or nucleated red blood cells in a sample, which comprises at least one fluorescent dye defined in the formula (I) or (II) is disclosed. Also disclosed are a kit and method for measuring basophils and/or nucleated red blood cells... | 04/24/2012 |
| 8158340 | Methods for detecting conformational changes in bioentities Described herein are methods for detecting conformational changes in bioentities. ... | 04/17/2012 |
| 8153358 | Selection and enrichment of proteins using in vitro compartmentalization Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous drople... | 04/10/2012 |
| 8153359 | Toxicity assay based on human blastocyst-derived stem cells and progenitor cells An in vitro toxicity assay based on human blastocyst-derived stem cells for the detection of toxicity in the human species is provided, which enables novel detection of in vitro human toxicity for a substance and/or more efficiently detects human toxicity compared t... | 04/10/2012 |
| 8148058 | Method for screening allergic disease-related molecule and cell lines to be used in the method An allergic disease-related substance is screened from candidate substances based on the reactivity to a plurality of cell lines, which are basophil-like or mast cell-like cell lines derived from the same spleen tissue and have different sensitivities to allergic cy... | 04/03/2012 |
| 8148056 | Methods of identifying modulators of GPR81 receptors Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity. ... | 04/03/2012 |
| 8148057 | Methods, immunoassays and devices for detection of anti-lipoidal antibodies Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a s... | 04/03/2012 |
| 8142994 | Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurali... | 03/27/2012 |
| 8142996 | Mass spectrometric determination of blood enzyme activity The invention relates to the determination of the nature and strength of enzymatic activity in blood using mass spectrometric measurement of a profile of the reaction products. The determination of the enzymatic activity can be used for medical diagnostics, for exam... | 03/27/2012 |
| 8142995 | Method for assessing arteriosclerosis and diabetic nephropathy A method for assessing arteriosclerosis comprising measuring the serotonin level in whole blood, serum or platelet-rich plasma and rating the serotonin level on such a scale that the lower it is, the more serious the arteriosclerosis is. ... | 03/27/2012 |
| 8137905 | Apparatus and method for determining an analyte in a fluid The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and... | 03/20/2012 |
| 8137904 | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent protein for the preparation of a diagnostic composition for diagnosis and... | 03/20/2012 |
| 8129105 | Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisot... | 03/06/2012 |
| 8124331 | In vitro method to detect bladder transitional cell carcinoma The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cance... | 02/28/2012 |
| 8124332 | Methods of using sIP-10, CD26 inhibitors and CXCR3 levels in a sample to assess clearance of infection, response to interferon therapy, and treating chronic infections The present invention relates to methods for the treatment of infection, a disease, or a condition using CD26 (DPIV) inhibitors. The present invention also relates to an antibody that binds to the IP-10 protein and a method of monitoring the necessity for administer... | 02/28/2012 |
| 8124330 | Screening methods for cognitive enhancers The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunctions and for enhancing me... | 02/28/2012 |
| 8114583 | Switch-region: target and method for inhibition of bacterial RNA polymerase A target and methods for specific binding and inhibition of RNA polymerase from bacterial species are provided, including methods for identifying agents that bind to a bacterial RNA polymerase, and that inhibit an activity of a bacterial RNA polymerase, through inte... | 02/14/2012 |
| 8114584 | Antireflective coatings for high-resolution photolithographic synthesis of DNA array The present invention provides an array of polymers and methods of forming arrays of polymers by providing a substrate having a first layer including one or more dielectric coatings on a solid support and a second layer including a plurality of polymers disposed on ... | 02/14/2012 |
| 8114582 | Fluorescence polarization instruments and methods for detection of exposure to biological materials by fluorescence polarization immunoassay of saliva, oral or bodily fluids The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and dete... | 02/14/2012 |
| 8114581 | Methods and compositions for detecting neoplastic cells Methods and compositions for identifying neoplastic cells in a biological sample are provided. ... | 02/14/2012 |
| 8110348 | Methods and compositions for the diagnosis and treatment of schizophrenia Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the ... | 02/07/2012 |
| 8110349 | Method for producing biomolecule diagnostic devices A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activat... | 02/07/2012 |
| 8110347 | Diagnostic method for detecting cancer by measuring amount of cytokine like IL-6 The present invention relates to a diagnostic method for predicting the possible recurrence of tumors in cancer patients. The method comprises culturing blood cells from a patient suffering from cancer in the presence of a cytokine stimulating factor, where after th... | 02/07/2012 |
| 8105766 | Method of measuring pyrophosphate Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenas... | 01/31/2012 |
| 8097404 | Composition and method for cell permeabilization comprising N-octyl-β-D-glucopyranoside, sodium polyphosphates, rubidium chloride and/or lithium chloride for detecting living cells on a membrane The present invention relates to a composition for the permeabilization of the walls of microorganisms comprising the combination of octyl-β-D-glucopyranoside (NOG), sodium polyphosphates (HMP), and a salt chosen from lithium chloride or rubidium chloride, and a me... | 01/17/2012 |
| 8092989 | Targeting the histone code as a bacterial strategy for selectively modulating gene expression The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins in... | 01/10/2012 |
| 8092988 | Medium and method of deriving and using a mutated bacteria strain A new strain of Bacillus anthracis derived from the Sterne vaccine strain of Bacillus anthracis by growth on a high-nitrate-concentration, 3-amino-L-tyrosine growth medium. ... | 01/10/2012 |
| 8088569 | Immunogens for treatment of neoplastic and infectious disease The present invention relates to prophylactic and therapeutic methods of immunization against neoplastic and infectious diseases. The invention provides a method for identification of novel immunogens and compositions of such immunogens that are useful for eliciting... | 01/03/2012 |
| 8088570 | Method for screening an agent for preventing or ameliorating wrinkles There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a... | 01/03/2012 |
