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| Number | Title | Issue Date |
| 8080419 | Process for recycling solid supports for cultivation of anchorage-dependent cells This invention relates to methods for use in industrial production of proteins. Specifically, the present invention provides a method of recycling solid supports for cultivation of anchorage-dependent cells such as, e.g., microcarriers and Fibra-Cel® disks. Solid s... | 12/20/2011 |
| 8017395 | Seeding cells on porous supports The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the ... | 09/13/2011 |
| 7799563 | Carrier fiber assembly for tissue structures Methods and structures are disclosed where carrier fiber is used to enable the assembly of two and three dimensional structures of autologous tissue. Tissue is harvested from the donor, integrated with a carrier fiber, and assembled into complex forms rapidly. The s... | 09/21/2010 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7195912 | Hydrogel thin film containing extracellular matrix components The thin film of the invention comprises a hydrate of a vitrified gel containing one or more extracellular matrix components, which can be integrated with a retainer as required. A hydrogel thin film containing one or more extracellular matrix components such as thi... | 03/27/2007 |
| 7192769 | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exog... | 03/20/2007 |
| 7179643 | Device and a process for expansion of haemopoeitic stem cells for therapeutic use A sterilizable bio-reactor comprising a three-dimensional reactor culture assembly substantially equivalent to a bone marrow micro environment, an inert bio-compatible scaffolding material located on a base of the reactor culture assembly to provide a micro environm... | 02/20/2007 |
| 7122371 | Modular cell culture bioreactor An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits fluidly connecting the at least one reservoir with the plurality of cha... | 10/17/2006 |
| 7101545 | Method for using human intervertebral disc cells There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a growth factor, or a cytokine or a bioactive agent to form monolayer pr... | 09/05/2006 |
| 7087431 | Ex vivo generation of functional leukemia cells in a three-dimensional bioreactor The present invention provides cultured leukemia cells. The method comprises isolating mononuclear cells, which contain leukemia cells, culturing the leukemia cells in a chamber having a scaffolding covered or surrounded with culture medium, where the scaffolding al... | 08/08/2006 |
| 7029838 | Prevascularized contructs for implantation to provide blood perfusion This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs followi... | 04/18/2006 |
| 7015038 | Method and apparatus for preparing and culturing cells A method and an apparatus for preparing and culturing cells, particularly bone marrow stromal cells. The method includes the steps of placing an oxygenator and a scaffold in a container, such as a syringe, withdrawing bone marrow stromal cells with the syringe, even... | 03/21/2006 |
| 7008634 | Cell growth substrates with tethered cell growth effector molecules Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substr... | 03/07/2006 |
| 6960427 | Process for producing a vascularized bioartificial tissue and an experimental reactor for carrying out the process The invention concerns a process for producing a three-dimensional bioartificial tissue having viable cells in or on a matrix, and by which cells and matrix can be cultivated into a tissue or a precursor of a tissue, a vascularized tissue of biological materials, ob... | 11/01/2005 |
| 6943008 | Bioreactor for cell culture A bioreactor for cell culture includes a chamber having three channels therethrough for conducting fluids, the three channels including an upper channel, a middle channel, and a lower channel, each the channel having an inlet and an outlet approximately opposite alo... | 09/13/2005 |
| 6911201 | Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationa... | 06/28/2005 |
| 6902932 | Helically organized silk fibroin fiber bundles for matrices in tissue engineering The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provide... | 06/07/2005 |
| 6875605 | Modular cell culture bioreactor and associated methods An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits fluidly connecting the at least one reservoir with the plurality of cha... | 04/05/2005 |
| 6759245 | Cell culture systems and methods for organ assist devices The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are gro... | 07/06/2004 |
| 6667049 | Relic process for producing bioresorbable ceramic tissue scaffolds A relic process is used to produce bioresorbable ceramic scaffolds that can be used for in vitro or in vivo growth of human or animal tissue such as bone or cartilage. The process involves impregnating an organic fabric template with metal and phosphate c... | 12/23/2003 |
| 6562374 | Biodegradable porous polymer scaffolds for tissue engineering prepared from an effervescent mixture and its preparation The present invention provides a method for preparing biodegradable porous polymer scaffolds for tissue engineering, comprising: a) fabricating a polymer sample from a polymer solution containing at least one biodegradable polymer and an effervescent mixture; ... | 05/13/2003 |
| 6399380 | Native-state histoculturing skin extracellular support Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal surface of the skin is adjacent to the matrix and the external s... | 06/04/2002 |
| 6379963 | Process for producing a vascularized bioartificial tissue and an experimental reactor for carrying out the process The invention concerns a process for producing a three-dimensional bioartificial tissue having viable cells in or on a matrix, and by which cells and matrix can be cultivated into a tissue or a precursor of a tissue, a vascularized tissue of biological ma... | 04/30/2002 |
| 6365149 | Porous tissue scaffoldings for the repair or regeneration of tissue The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers ... | 04/02/2002 |
| 6281007 | Methods and apparatus for the conditioning of ligament replacement tissue Apparatus and methods are disclosed for maturing an elongate replacement tissue construct in vitro prior to use of the replacement construct in vivo as, for example, a ligament. The tissue is seeded with specific cells, exposed to a maturation fluid, and ... | 08/28/2001 |
| 6146892 | Fibrillar matrices Methods and compositions are described that provide three-dimensional fibrillar matrices useful as, among other things, structural prosthetics and scaffolds for cells. The porous fibrillar matrices of the present invention have desirable mechanical proper... | 11/14/2000 |
| 6140039 | Three-dimensional filamentous tissue having tendon or ligament function A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal cells along with connective tissue proteins naturally secreted... | 10/31/2000 |
| 6093558 | Binding protein of biologically active compositions to an adhesive formulation on a substrate Compositions and methods are provided for adhering and binding biologically active proteins and protein-containing composites to substrates. Adhesive formulations comprising a nonproteinaceous polymer of monomeric units comprising an aromatic moiety subst... | 07/25/2000 |
| 6080579 | Method for producing human intervertebral disc cells There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a growth factor, or a cytokine or a bioactive agent to form m... | 06/27/2000 |
| 6045818 | Cell growth substrates with tethered cell growth effector molecules Disclosed are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a s... | 04/04/2000 |
| 6022743 | Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro A stromal cell-based three-dimensional cell culture system is prepared which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal cells and connective tissue proteins naturally secreted by the... | 02/08/2000 |
| 6017760 | Isolation and culture of porcine hepatocytes A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and ... | 01/25/2000 |
| 5906828 | Cell growth substrates with tethered cell growth effector molecules Disclosed are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a s... | 05/25/1999 |
| 5902741 | Three-dimensional cartilage cultures The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using TGF-ଲ in the culture medium. In accordance with the i... | 05/11/1999 |
| 5858721 | Three-dimensional cell and tissue culture system The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue ar... | 01/12/1999 |
| 5849579 | Native-state histoculturing method for skin Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal surface of the skin is adjacent to the matrix and the external s... | 12/15/1998 |
| 5849588 | Methods of use of a three-dimensional liver cell and tissue culture system The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro in an environment that more closely approximates that found... | 12/15/1998 |
| 5846828 | Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing heart valves is disclosed. Specifically, the present invention relates to an apparatus and method for dynamically seeding and culturing heart valves with human cel... | 12/08/1998 |
| 5792603 | Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing vascular grafts is disclosed. Specifically, the present invention relates to an apparatus and method for seeding and culturing vascular grafts with human cells. Th... | 08/11/1998 |
| 5786215 | Method for culturing animal cells An apparatus and method for the in vitro culturing of animal cells, e.g., mammalian cells, to attain mass growth of the cells per se and/or to recover cell-secreted products of interest therefrom, in which an integral culture and gassing element is formed... | 07/28/1998 |
