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| Number | Title | Issue Date |
| 8158425 | Cell culture scaffold containing gel having interpenetrating polymer network structure A cell culture scaffold containing a gel having a network structure comprised of a synthetic polymer such that cultured cells spread in a shorter time and the number of adsorbed cultured cells per unit area is larger than in the case of using a gel having a network ... | 04/17/2012 |
| 8129188 | Cell culture apparatus and method of fabricating the apparatus A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materia... | 03/06/2012 |
| 8076295 | Peptide amphiphiles having improved solubility and methods of using same Disclosed herein are novel peptide amphiphile molecules and compositions discovered to possess improved solubility in aqueous buffers which, in turn, facilitates purification required for pharmaceutical applications, particularly for in vivo administration to human ... | 12/13/2011 |
| 7749761 | Hydrogel composition for cell culture apparatus A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materia... | 07/06/2010 |
| 7452720 | Apparatus for preparing a biocompatible matrix An apparatus and method of using the apparatus to prepare a biocompatible biodegradable matrix capable of supporting cells to form an implantable or engraftable surgical device. A matrix-forming fluid is contained within a chamber defined by top and bottom surfaces ... | 11/18/2008 |
| RE40555 | Preparation of agarose coated, solid agarose beads containing secretory cells Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and sec... | 10/28/2008 |
| 7435594 | Scaffold for culturing cells A cell culture scaffold containing a gel having a network structure comprised of a synthetic polymer such that cultured cells spread in a shorter time and the number of adsorbed cultured cells per unit area is larger than in the case of using a gel having a network ... | 10/14/2008 |
| 7407672 | Composition derived from biological materials and method of use and preparation The invention provides a novel composition and methods of its preparation and uses. The composition comprises as main components serum and a gelling agent and is useful in various medical applications. The composition may be used to coat a medical device, as a biolo... | 08/05/2008 |
| 7364921 | Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a... | 04/29/2008 |
| 7297331 | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 11/20/2007 |
| 7267982 | Carrier for cell culture A carrier for cell culture comprising a carrier having a cationic group and polypeptide-modified portions formed on a surface of the carrier in a sea-island structure, and a carrier for cell culture comprising a water-containing gel comprising alginic acid, wherein ... | 09/11/2007 |
| 7244552 | Artificial dermis and production method therefor Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fi... | 07/17/2007 |
| 7217570 | Organotypic intestinal culture and methods of use thereof An organotypic culture comprises an artificial stroma overlayed with epithelial cells isolated from a human colon or intestine. The stroma comprises a mixture of collagen and human fibroblasts isolated from a human colon or intestine. The culture contains a factor t... | 05/15/2007 |
| 7195912 | Hydrogel thin film containing extracellular matrix components The thin film of the invention comprises a hydrate of a vitrified gel containing one or more extracellular matrix components, which can be integrated with a retainer as required. A hydrogel thin film containing one or more extracellular matrix components such as thi... | 03/27/2007 |
| 7074552 | Method of forming vascularized kidney tissue A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to effectuate its biological function of filtering body fluids. A single dono... | 07/11/2006 |
| 7041505 | Carrier for cell culture A carrier for cell culture comprising an alginic acid gel layer laminated with a gel layer containing a cell adhesion substance, wherein the gel layer containing a cell adhesion substance has a dry thickness of less than 0.3 μm. The carrier for cell culture enables... | 05/09/2006 |
| 7022523 | Carrier for cell culture A carrier for cell culture comprising a water-containing polymer gel containing chitosan, wherein the water-containing polymer gel is coated with collagen and/or alginic acid, and a carrier for cell culture, which comprises a gel layer containing chitosan and an ino... | 04/04/2006 |
| 7011829 | Tissue filler Disclosed are a tissue filler and tissue reconstruction method using the same that enables missing or reduced tissue of a body to recover to a normal state thereof, and the tissue filler comprised by mixing mesenchymal stem cells into a hydrochloric acid solution of... | 03/14/2006 |
| 6974679 | Support with collagen base for tissue engineering and manufacture of biomaterials The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising ... | 12/13/2005 |
| 6960452 | Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins Disclosed are materials that may be used in the design of improved devices and wound treatment platforms though covalent and/or non-covalent attachment of bioactive proteins. The proteins comprise any variety of cell growth and/or healing promoting proteins, such as... | 11/01/2005 |
| 6897064 | Cell or tissue-culturing carrier, and culturing method A cell or tissue-culturing carrier which can effectively regenerate an intended a cell or tissue, while suppressing an excessive growth of fibroblasts, and a method of culturing a cell or tissue by using the above carrier, the cell or tissue-culturing carrier wherei... | 05/24/2005 |
| 6790840 | Reversibly cross-linked hydrogels A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polys... | 09/14/2004 |
| 6790606 | Extracellular matrix signaling molecules Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compos... | 09/14/2004 |
| 6743630 | Method of preparing a protein array based on biochemical protein-protein interaction A method of preparing a protein array based on biochemical protein-protein interaction is provided. An array of a first protein which includes a PDZ domain is deposited on a substrate. A second protein, which includes an amino acid sequence (S/T)—X—(V/I/L)—COO... | 06/01/2004 |
| 6730298 | Tissue formation by injecting a cell-polymeric solution that gels in vivo Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is... | 05/04/2004 |
| 6709864 | Adipogenic differentiation of human mesenchymal stem cells A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogen... | 03/23/2004 |
| 6653089 | Differential treatment of selected parts of a single cell with different fluid components The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in cer... | 11/25/2003 |
| 6642050 | Three-dimensional cell culture material having sugar polymer containing cell recognition sugar chain A cell culture material comprising a sugar containing polymer in which at least one kind of sugar chain is bonded as a side chain via a spacer molecule is made into a three-dimensional shape whereupon a three-dimensional cell material is prepared. With re... | 11/04/2003 |
| 6627422 | Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may be formed of a plurality of monofilaments twisted into yarn... | 09/30/2003 |
| 6586246 | Preparing porous biodegradable polymeric scaffolds for tissue engineering using effervescent salts Three-dimensional porous biodegradable and biocompatible, polymeric scaffolds for tissue engineering are prepared by a method involving effervescing of an effervescent salt in a gel to result in a porous structure. A polymer is dissolved in an organic sol... | 07/01/2003 |
| 6569442 | Preparation of polymer foam having gelled sol coating for intervertebral disc reformation Methods and materials are provided for reforming degenerated intervertebral discs of the spine of a vertebrate and in particular the spine of a human. Tissue is evacuated from the nucleus pulposus portion of a degenerated intervertebral disc space, and a ... | 05/27/2003 |
| 6541023 | Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained Use of collagen of aquatic origin for the production of supports for tissue engineering is disclosed. The collagen may be obtained from fish skin, preferably in its native form. Novel tissue engineering supports with a low risk of contamination are produc... | 04/01/2003 |
| 6524787 | Diagnostics and therapy based on vascular mimicry The disclosed invention is directed to methods and apparatus for detection, prognostic diagnosis, treatment and prevention of cancer and other hyperproliferative disorders in humans and animals. More particularly, the present invention is directed to vasc... | 02/25/2003 |
| 6471958 | Non-contracting tissue equivalent The present invention provides a non-contracting tissue equivalent comprising at least one cellular component and at least one non-cellular component. The tissue equivalent closely resembles normal tissue in being substantially non-contracting. In additio... | 10/29/2002 |
| 6464998 | Composition for the in vivo production of therapeutic products The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.... | 10/15/2002 |
| 6379953 | Ligands that modulate differentiation of mesenchymal stem cells Disclosed are compositions and methods for accelerating the differentiation of human MSCs into the osteogenic lineage with resultant enhanced de novo bone formation. This makes possible improved methods for bone defect repair. Thus, one aspect of the inve... | 04/30/2002 |
| 6352707 | Transplant encapsulation in a hydrogel matrix to obscure immune recognition Immune recognition of a transplant such as tissue implanted in a host mammal is obscured by encapsulating the transplant in a hydrogel matrix containing gelatin, dextran, at least one nitric oxide inhibitor and polar amino acids. The polar amino acids inc... | 03/05/2002 |
| 6303375 | Cell supporting matrix, cell culture device, and fluid treating device A matrix for supporting cells such as animal cells is provided that enables cells to be supported at high efficiency and density in a short period. The matrix contains a plurality of cone shaped pores having an average diameter opening in an upstream surf... | 10/16/2001 |
| 6300128 | Method for fixing cultured tissue and artificial skin fixed A matrix for tissue culture comprising two kinds of sponges having at least one different physical property and/or at least one different chemical property; a method for culturing tissue using said matrix for tissue culture comprising inoculating and cult... | 10/09/2001 |
| 6287558 | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule A device that includes a living cell or tissue and an agent that inhibits the ability of a host molecule to damage the cell or tissue. The device can be constructed in various forms including an implantable device, a composite microreactor and a double co... | 09/11/2001 |
