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| Number | Title | Issue Date |
| 8187880 | Composite materials comprising supported porous gels containing metal-affinity ligands This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked... | 05/29/2012 |
| 8183042 | Multi-layered implant prepared by a method of tissue repair using a multi-layered matrix A multi-layered matrix, a method of tissue repair using the same, and multi-layered implant prepared thereof are provided. The multi-layered matrix comprises a first element and a second element connected thereto, and the second element comprises a hollow cavity. Th... | 05/22/2012 |
| 8183041 | Method of tissue repair using a multi-layered matrix A multi-layered matrix, a method of tissue repair using the same, and multi-layered implant prepared thereof are provided. The multi-layered matrix comprises a first element and a second element connected thereto, and the second element comprises a hollow cavity. Th... | 05/22/2012 |
| 8163556 | Method of cell culture observation, carbon substrate for cell culture observation, and method for manufacture thereof The invention provides a substrate suitable for cell culture observation and a method of observation using the same. Crystalline carbon such as a graphite powder is mixed into a thermosetting resin such as a furan resin, and the mixture is molded in the shape of a s... | 04/24/2012 |
| 8114670 | Skin equivalent culture Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in o... | 02/14/2012 |
| 8097457 | Liquid crystalline substrates for culturing cells The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix componen... | 01/17/2012 |
| 8097456 | Nanotopographic compositions and methods for cellular organization in tissue engineered structures The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types. ... | 01/17/2012 |
| 8080418 | Method of making a three dimensional cell culture matrix This invention relates three dimensional porous cell culture matrices or scaffolds which have directional porous structure. More particularly, this invention relates to three dimensional porous cell culture matrices or scaffolds for cell culture which are derived fr... | 12/20/2011 |
| 8076137 | Tissue engineered cellular sheets, and methods of making same The disclosure provides methods and compositions to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body re... | 12/13/2011 |
| 8071382 | Porous nanofiber mesh for three-dimensional cell culture Disclosed is a mesh for cell culture in which linear nanofiber is cross-linked to form a network, wherein the linear nanofiber is composed of polyhydroxyalkanoate; or polyhydroxyalkanoate, and collagen, gelatin or their mixture. The mesh for cell culture of the pres... | 12/06/2011 |
| 8062890 | Defined surfaces of self-assembled monolayers and stem cells A method for the construction of arrays from self-assembling monolayers is described. The arrays have particular utility for the screening of peptides ligands that can foster the growth of cells in culture. This technique has been used to identify peptide ligands th... | 11/22/2011 |
| 8034618 | PTH containing cell growth matrix Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffu... | 10/11/2011 |
| 8034617 | Cell culture in culture media free of components of animal origin The present invention relates to a process for animal, preferably human, diploid anchorage-dependent cell culture, in the absence of exogenous components of primary animal origin, and to a cell culture medium substantially free of exogenous components of primary ani... | 10/11/2011 |
| 8003388 | Method for creating perfusable microvessel systems A method for creating networks of perfusable microvessels in vitro. A mandrel is drawn through a matrix to form a channel through the matrix. Cells are injected into the channel. The matrix is incubated to allow the cells to attach inside the channel. The channel is... | 08/23/2011 |
| 7993922 | Three-dimensional tissue equivalent using macromass culture The present invention provides a three-dimensional tissue equivalent for in-vivo and in-vitro uses. The three dimensional tissue equivalent of the present invention is a non-contractile cellular sheet cultured over a porous scaffold using a macromass culturing techn... | 08/09/2011 |
| 7972852 | Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same A reconstructed artificial tissue is obtained by seeding and culturing desired homogeneous or heterogeneous cells having an ability to form a basement membrane on the basement membrane specimen constructed by the following process: the cells having an ability to for... | 07/05/2011 |
| 7947500 | Liquid crystalline substrates for culturing cells The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix componen... | 05/24/2011 |
| 7919319 | Cultured cell and method and apparatus for cell culture One or more cells can be cultured when confined in space by barriers. The distance between barriers can be comparable to the size of a cell to be cultured. The space between barriers can also be sufficiently small to allow control of cell properties or monitoring of... | 04/05/2011 |
| 7906332 | Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; ... | 03/15/2011 |
| 7888119 | Tissue substitutes comprising stem cells and reduced ceria A biocompatible composite includes a solid biocompatible material and a plurality of living human progenitor or living stem cells attached thereto. The biocomposite provides a stable interface with endogenous tissue and the implanted composition resulting in acceler... | 02/15/2011 |
| 7879607 | Elastomeric device for cell seeding on the bottom of a filter An article is provided herein for use in seeding cells on at least one filter extending across at least one well of an assay device. The article includes an elastomeric body having spaced-apart first and second surfaces, and at least one channel extending between, a... | 02/01/2011 |
| 7846728 | Tissue engineering in vivo with vascularized scaffolds The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing larg... | 12/07/2010 |
| 7846727 | Substratum having a pattern of cell-culture controlling substance The present invention relates to a substrate for cell culture capable of controlling at least one function selected from adhesion, proliferation, differentiation, survival, maintenance of undifferentiated state, and apoptosis of a cell. The substrate comprises an im... | 12/07/2010 |
| 7795027 | Extracellular matrix composite materials, and manufacture and use thereof Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft... | 09/14/2010 |
| 7759120 | Seeding implantable medical devices with cells Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are i... | 07/20/2010 |
| 7732204 | Cell culture method and apparatus for mechanically stimulating cells A cell culture assembly and a method for culturing cells that provide mechanical stimulation to cells. The cell culture assembly can include a flow chamber positioned in a fluid path and a support comprising cells positioned within the flow chamber to expose the cel... | 06/08/2010 |
| 7700355 | Methods of producing a porous matrix for culturing and recovering cells A porous matrix, preparation thereof, and methods of using the same. The porous matrix of calcium alginate is prepared using a plurality of particles containing a multivalent cation, admixing the particles with ionic cross-linked polysaccharides and water to form a ... | 04/20/2010 |
| 7635592 | Tissue engineering scaffolds promoting matrix protein production Matrix-enhancing molecules, such as TGF-β, are conjugated to or immobilized on scaffolds to increase ECM production by cells for tissue engineering, tissue regeneration and wound healing applications. The matrix-enhancing molecule is conjugated to a tether, such as... | 12/22/2009 |
| 7622298 | Method for creating perfusable microvessel systems Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with f... | 11/24/2009 |
| 7579189 | Aligned scaffolds for improved myocardial regeneration The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contai... | 08/25/2009 |
| 7541187 | Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix Method of providing a substrate with a ready-to-use uniformly distributed extracellular matrix is disclosed. This method includes applying extracellular matrix components to a substrate area; incubating the extracellular matrix components to allow polymerization the... | 06/02/2009 |
| 7534609 | Method of expanding undifferentiated hemopoietic stem cells A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic stem cells; and (b) culturing the undifferentiated hemopoietic stem ... | 05/19/2009 |
| 7504258 | Tissue engineered cellular sheets, methods of making and use thereof The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body res... | 03/17/2009 |
| 7442546 | Method of modulating inflammatory response A method of immunomodulation by contacting the bodily fluid of a patient with renal tubule cells outside of the kidney. ... | 10/28/2008 |
| RE40555 | Preparation of agarose coated, solid agarose beads containing secretory cells Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and sec... | 10/28/2008 |
| 7440160 | Electro-optical light modulating element, electro-optical display and modulating medium The invention relates to electrooptical light modulating elements, to electrooptical displays containing elements of this type, and to display systems, e.g. television screens and computer monitors, and to the modulating media used therein. The inventive light modul... | 10/21/2008 |
| 7439057 | Convective flow tissue assembly The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components that provide for the circulation of culture media and cell suspensions... | 10/21/2008 |
| 7435594 | Scaffold for culturing cells A cell culture scaffold containing a gel having a network structure comprised of a synthetic polymer such that cultured cells spread in a shorter time and the number of adsorbed cultured cells per unit area is larger than in the case of using a gel having a network ... | 10/14/2008 |
| 7422900 | System and method for forming a connective tissue construct A system and method are provided for forming a connective tissue construct, such as a tendon construct, in vitro. A substrate is provided with at least two anchors secured thereto in spaced relationship. Fibroblast cells are provided on the substrate in the absence ... | 09/09/2008 |
| 7422879 | Process for producing porous polymer films Porous films are provided which include a blend of a film forming polymer and a non-film forming material, the film having a network of pores or channels throughout the film. The porous polymer films are formed between 0° and 80° C., retain porosity at elevated te... | 09/09/2008 |
