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| Number | Title | Issue Date |
| 7947499 | Method of dynamically culturing embryonic stem cells The present invention is of a method of dynamically generating human embryoid bodies which can be used for generating lineage specific cells and cell lines. Specifically, the present invention can be used to generate ESC-differentiated cells for cell-replacement the... | 05/24/2011 |
| 7588938 | Neural stem cell-collagen-bioreactor system to construct a functional embryonic brain-like tissue A method of generating tissue from stem and progenitor cells is disclosed. Primary mammalian stem cells and progenitor cells are placed in an extracellular matrix. The matrix is maintained in a culture medium and a microgravity environment. ... | 09/15/2009 |
| 7476541 | Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue Methods and apparatus for a bioreactor system for growing cells are provided. The bioreactor system includes a reaction chamber for cultivating harvested tissue in a culture medium, and a hydrodynamic apparatus connected to the reaction chamber that generates a cycl... | 01/13/2009 |
| 7456019 | Three-dimensional cell to tissue development process An improved three-dimensional cell to tissue development process using a specific time varying electromagnetic force, pulsed, square wave, with minimum fluid shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of p... | 11/25/2008 |
| 7410792 | Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning tissue engineered medical products. The microprocessor control providing measurement and control of the tissue displacement and subsequent determination of material and growth properties. The m... | 08/12/2008 |
| 7410798 | Culture system for rapid expansion of human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 08/12/2008 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7347872 | Connective tissue substitutes, method of preparation and uses thereof The present invention relates to connective tissue substitute implant and method of preparation thereof. The implant is essentially composed of two bone anchors joined at the proximal ends by matrix layers and/or filaments coated by supplementary biocompatible matri... | 03/25/2008 |
| 7341863 | Method for the degradation of MTBE and TBA A method for the degradation of methyl-tertiary-butyl-ether (MTBE) and tertiary-butanol (TBA) using a mixture of Pseudomonas putida is described. The method enables almost complete remediation of MTBE and TBA in situ in contaminated water and/or soil. ... | 03/11/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7323333 | Materials and methods for regulating process formation in cell culture The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In ... | 01/29/2008 |
| 7297539 | Medium for growing human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 11/20/2007 |
| 7291500 | 3-dimensional clinostat for cell culture In order to grow an object to be cultivated or grown, a growth object is encapsulated in a vessel, and the growth object is grown without substantial influence of gravity. ... | 11/06/2007 |
| 7264805 | Proteins with a high immunoreactivity and a method for the production thereof The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced using a fluidized bed reactor in conjunction with a conventional protein-chemic... | 09/04/2007 |
| 7160719 | Bioartificial liver system A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes... | 01/09/2007 |
| 7153665 | Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement. ... | 12/26/2006 |
| 7144716 | Recovery method for immobilized biocatalysts Processes for the production of a product by the enzymatic treatment of a soluble or particulate substrate with a particulate, immobilized enzyme, by treating a process liquor containing the substrate in a bioreactor to produce a slurry of effluent immobilized enzym... | 12/05/2006 |
| 7128463 | Portable mixer A portable mixer comprising a frame assembly. Wheels are operatively mounted on the frame assembly. A deck assembly is pivotally mounted on the frame assembly for tilting forwardly and rearwardly. A mixing bag is suspended from the frame assembly. ... | 10/31/2006 |
| 7112441 | 3-dimensional klinostat for culture of cells In order to grow an object to be cultivated or grown, a growth object is encapsulated in a vessel, and the growth object is grown without substantial influence of gravity. ... | 09/26/2006 |
| 7071005 | Method and device for concentrating selected groups of microorganisms A method and device are described to concentrate target organisms from a mixture of organisms. Beads (1) made of material such as nylon, polystyrene or glass are coated with antibodies of specific microorganisms. The beads (1) are contained in an enclo... | 07/04/2006 |
| 7067307 | Bioartificial device for the storage, cultivation and/or multiplication of cells The bioartificial reactor has a reactor vessel. A cell culture chamber in the reactor, in particular for liver cells, is divided off from a flow chamber for a nutritive medium and from a flow chamber for plasma and blood by semipermeable walls. At least one flow cha... | 06/27/2006 |
| 6998264 | Replication of biological tissue Biological tissues are grown in a low shear, microgravity environment by culturing connective tissue cells to form a three-dimensional structure, which is thereafter co-cultured with endothelial and epithelial cells to replicate naturally occurring tissues. Preferab... | 02/14/2006 |
| 6946242 | Method for maintaining the viability of sperm A rocker for extended, refrigerated storage or transport of fish sperm comprising a platform for sperm containers, drive mechanism, a power supply with an on/off switch or rheostat, and water resistant housing. This device imparts continuous rocking motion to the sp... | 09/20/2005 |
| 6933144 | Apparatus for growing cells A cell-culture apparatus forms an extra-capillary space between at least one hollow fiber and an enclosed chamber. Cells are placed in the extra-capillary space to grow. A media reservoir holds a cell-culture medium. The cell-culture medium is allowed to pass throug... | 08/23/2005 |
| 6902909 | Methods for efficient production of mammalian recombinant proteins A process has been developed for the production of human recombinant polypeptides using transformed mammalian cells cultured in a horizontally rotating culture vessel modulated to create low shear, high mass transfer conditions. The resulting recombinant polypeptide... | 06/07/2005 |
| 6890755 | Recovery of fetal cells from maternal blood using chaotic advection To extract fetal cells from a sample of maternal blood or a fluid derived from maternal blood, sample liquid is moved over a collector surface bearing a ligand for the fetal cells. Chaotic advection in the liquid enhances the efficiency of cell collection. ... | 05/10/2005 |
| 6815204 | Method for improving transfer in a biological reaction chamber The invention relates to a method of improving the transfer in an annular biological reaction chamber defined by coaxial inner and outer walls (11, 12) and in which there flows a liquid reaction medium containing a culture of microorganisms or of cells from v... | 11/09/2004 |
| 6730498 | Production of functional proteins: balance of shear stress and gravity The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a... | 05/04/2004 |
| 6703217 | Methods and devices for remediation and fermentation The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized in an open chamber defined by two rotating disks. The fluid force of nutrient fluids flowing into the chamber opposes the c... | 03/09/2004 |
| 6660509 | Methods and devices for remediation and fermentation Abstract of the Invention The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support com... | 12/09/2003 |
| 6607910 | Two chamber cell culture vessel A two-chamber perfusion bioreactor counteracts a significant amount of shear stress while allowing high nutrient transfer and removal of waste and/or valuable bio-products, e.g., protein, hormones, growth factors, and monoclonal antibodies without disturb... | 08/19/2003 |
| 6544788 | Disposable perfusion bioreactor for cell culture A disposable bioreactor for perfusion cell culture. Cells are grown in a plastic bag that is rocked and aerated on a mechanical platform. The bioreactor bag contains a filter that allows liquid to be removed from the bioreactor-without losing cells. Nutri... | 04/08/2003 |
| 6492163 | Cell culture tube and multiple roller tube cell culture system using the same A cell tube for ex vivo culturing animal cells and a multiple roller tube cell culture system are disclosed. Suitable for use in culturing cells, the tube has at its opposite end walls two openings through which culture media can come in and out. The open... | 12/10/2002 |
| 6479252 | Cell culture apparatus and methods of use Provided is a cell culture apparatus for culturing cells, and optionally, for performing magnetic separation of cells desired to be cultured. The cell culture apparatus preferably comprises a frame; two membranes, preferably each being gas permeable, whic... | 11/12/2002 |
| 6455310 | Cell culture apparatus and method for culturing cells Provided is a cell culture apparatus for culturing cells, and optionally, for performing magnetic separation of cells desired to be cultured. The cell culture apparatus preferably comprises a frame; two membranes, preferably each being gas permeable, whic... | 09/24/2002 |
| 6444459 | Apparatus having pitted or cratered inner surface for culturing biological material and methods thereof An apparatus for culturing biological material such as cells and methods of using the apparatus are disclosed. The apparatus may comprise a rough or uneven growth surface. The growth surface may be added to or formed as an integral part of the apparatus. ... | 09/03/2002 |
| 6410309 | Cell culture apparatus and methods of use Provided is a cell culture apparatus for culturing cells, and optionally, for performing magnetic separation of cells desired to be cultured. The cell culture apparatus preferably comprises a frame; at least one gas permeable membrane securedly sealed in ... | 06/25/2002 |
| 6261805 | Sialyiation of N-linked glycoproteins in the baculovirus expression vector system The present disclosure utilizes a novel approach to protein preparation in the baculovirus expression vector system (BEVS). Specifically, the present invention analyzes the effects of microgravity/low shear on complex glycosylation of proteins prepared vi... | 07/17/2001 |
| 6251653 | Method of improved mixing of a varicella-infected cell culture in roller bottles A method for enhancing the mixing of a varicella-infected cell culture in a roller bottle by the introduction of controlled cross-sectional flow perturbations in roller bottle rotation is disclosed. The effectiveness of the method is demonstrated by achie... | 06/26/2001 |
| 6214617 | Centrifugal fermentation process The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the r... | 04/10/2001 |
