Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7439064 | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferring, insuli... | 10/21/2008 |
| 7291122 | Hemofiltration methods for treatment of diseases in a mammal A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal ... | 11/06/2007 |
| 7285646 | Ultrapure transferrin for pharmaceutical compositions The present invention relates to an ultrapure human transferrin, and to methods for manufacturing the ultrapure transferrin. The transferrin may be holo-, apo- or at any desired degree of iron saturation. The invention further relates to the use of ultrapure transfe... | 10/23/2007 |
| 6733746 | Hematopoietic cell culture nutrient supplement The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the serum-free supplement of the present invention. The present invention also ... | 05/11/2004 |
| 6617161 | Serum-free cell growth medium A chemically defined-serum free growth medium for the in vitro and ex vivo of cells and cell lines. The medium consists of about a one to one ratio (v/v) of two basal growth media containing -ketoglutarate, insulin, transferrin, selenium, bovine se... | 09/09/2003 |
| 6617159 | Serum free medium for chondrocyte cells Serum free media for growth and proliferation of chondrocytes and mesenchymal stem cells in culture are provided. A serum free medium for growth of chondrocytes includes a serum free composition comprising FGF-2, linoleic acid, ascorbic acid, B-mercaptoet... | 09/09/2003 |
| 6413772 | Cell structure media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.... | 07/02/2002 |
| 6372493 | Hormone-secreting cells maintained in long-term culture Methods are provided for the establishment and maintenance in long term culture of hormone secreting cells. Cells are derived from tumorous or non-tumorous animal or human tissues, including ovary, endometrium, trophoblast, pituitary, thyroid, and pancrea... | 04/16/2002 |
| 6224860 | Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free medium A serum-free medium which supports the proliferation and differentiation of CD34+ cells purified from normal bone marrow, peripheral blood of patients treated with cytokines, and umbilical cord blood is described. The recipe for the formulation... | 05/01/2001 |
| 6103530 | Cultures of human CNS neural stem cells Isolation, characterization, proliferation, differentiation and transplantation of mammalian neural stem cells is disclosed.... | 08/15/2000 |
| 6043092 | Cell culture media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.... | 03/28/2000 |
| 6017760 | Isolation and culture of porcine hepatocytes A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and ... | 01/25/2000 |
| 5945337 | Method for culturing CD34+ cells in a serum-free medium A serum-free medium which supports the proliferation and differentiation of CD34+ cells purified from normal bone marrow, peripheral blood of patients treated with cytokines, and umbilical cord blood is described. The recipe for the formulatio... | 08/31/1999 |
| 5908782 | Chemically defined medium for human mesenchymal stem cells A composition and method for maintaining the viability of human mesenchymal precursor cells in a serum-free environment which composition includes (1) a minimum essential medium; (2) serum albumin; (3) an iron source; (4) insulin or an insulin-like growth... | 06/01/1999 |
| 5858783 | Production of normal mammalian organ culture using a medium containing mem-alpha, leibovitz L-15, glucose galactose fructose Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under micro-gravity culture conditions and form three dimensional cells aggregates with normal ce... | 01/12/1999 |
| 5849585 | Isolating and culturing Schwann cells A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as her... | 12/15/1998 |
| 5576194 | Recombinant protein production Recombinant Factor VIII production is increased by supplementing the serum-free culture of mammalian host cells containing the gene therefor in a serum-free nutrient media with lipoprotein obtained from a mammalian source, preferably low density human lip... | 11/19/1996 |
| 5474930 | Non-tumorigenic cell lines for expression of genes Non-tumorigenic cell lines capable of indefinite growth in serum-free media are disclosed. The cell lines are capable of expressing exogenously introduced genes, and may be derived from mouse embryo cells. Methods for producing proteins utilizing these ce... | 12/12/1995 |
| 5447861 | Continuous mammalian cell lines having monocyte/macrophage characteristics and their establishment in vitro Continuous mammalian cell lines having characteristics of immature monocytes and/or macrophages which have been established from normal mammalian cells, continuous human cell lines having characteristics of immature monocytes and/or macrophages which are ... | 09/05/1995 |
| 5409827 | Blended bovine sera cellular growth media and their methods of production and use The present invention provides media and methods for the maintenance or promotion of growth of a cellular line, particularly a hybridoma cellular line. A serum blend is disclosed comprising fetal bovine serum and agamma bovine calf serum. The serum blend ... | 04/25/1995 |
| 5342777 | Cell culture medium for human liver epithelial cell line The present invention relates to cell medium developed to support long term multiplication and permanent establishment of a cell line of human liver epithelial cells. The medium may contain an effective cell growth promoting amount of calcium ions; an eff... | 08/30/1994 |
| 5155036 | Serum-free medium containing retinoic acid useful for cultivating human/human hybridomas A serum-free medium for cultivating a human monoclonal antibody-producing human/human hybridoma, said medium comprising a serum-free complete medium and at least 10-12 M but not more than 10-6 M of retinoic acid or its salt.... | 10/13/1992 |
| 5063157 | Serum-free culture medium for mammalian cells The present invention provides a serum-free culture medium for mammalian cells, especially non-adherent cells, containing a base medium, transferrin, insulin and selenite, wherein it contains or consists of 2 to 10 mg./liter transferrin, 2 to 10 mg./liter insu... | 11/05/1991 |
| 4927762 | Cell culture medium with antioxidant Cells grown in chemically defined (serum free) media are protected against endogenous oxidizing agents by a nontoxic antioxidant with free thiol groups, at cell densities less than about 105 cells/ml, especially DL-penicillamine, N-acetylcystei... | 05/22/1990 |
| 4757005 | Method and cell line for obtaining plasminogen activators A method of increasing the yield of plasminogen activator from a plasminogen activator-producing cell line by adapting said cell line to grow in a suitable growth medium essentially free of fetal calf serum is disclosed. Also disclosed are cell lines capa... | 07/12/1988 |
| 4743552 | Method for growth in tissue culture of normal colonic epithelial cells and method for determination of preneoplastic color cells The invention concerns a method for the routine primary culture of human colonic epithelial cells within a monolayer. 12-0-tetradecanoylphorbol-13-acetate (TPA) enhanced DNA synthesis an average of 8 fold when assayed by [3 h]dThd labeling indi... | 05/10/1988 |
| 4654304 | Composition for cell cultivation, production and use thereof The present inventiona is directed to a mammalian serum-originated growth factor-containing composition useful in cell cultivation. The composition of the present invention is substantially free of active microorganisms and other harmful substances which ... | 03/31/1987 |
| 4615977 | Method for the cultivation of normal diploid cells and cultivation medium used therefor A method and medium for the multiplication of normal diploid cells from mammals is described, comprising cultivating the cells in a culture medium containing an amine derivative or derivatives represented by the general formula: NR1 R2 | 10/07/1986 |
| 4608341 | Living, fast-growing thyroid cell strain, FRTL-5 A fast growing, continuous, functional rat thyroid cell strain, FRTL-5, which maintains functional characteristics of iodide uptake and thyroglobulin synthesis over prolonged periods of culture is cloned from FRTL cells obtained from primary cultures of F... | 08/26/1986 |
| 4560655 | Serum-free cell culture medium and process for making same A defined serum-free medium that is capable of growing a wide range of suspension and monolayer cells includes a serum substitute composed of fetuin, transferrin, phosphatidylcholine, e.g., 1-oleoyl-2-palmitoyl-phosphatidylcholine, linoleic acid and chole... | 12/24/1985 |
| 4443546 | Process and composition for propagating mammalian cells A serum-free medium for use in propagating cells. A process involving growing normal mammalian cells in vitro in a serum-free medium. The process includes providing the cells to be grown with various hormones as well as required nutrients in a serum-free envir... | 04/17/1984 |
| 4440860 | Stimulating cell growth Compositions and methods for promoting cell growth featuring, in one aspect, cell culture media containing milk or colostrum and fibronectin; fibronectin is preferably pre-coated onto the culture substrate.... | 04/03/1984 |
