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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8058066 | Cellular factor-containing solution compositions The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), ... | 11/15/2011 |
| 7892830 | Clonal culture of human pluripotent stem cells While culture medium and systems have been described that permit the culture and proliferation of human embryonic stem cells in feeder free and animal product free conditions, these conditions will not readily support cloning of an embryonic stem cell culture meanin... | 02/22/2011 |
| 7795026 | Methods for obtaining human embryoid body-derived cells The invention is directed to novel cells that are derived from human embryoid bodies. Such embryoid body-derived (EBD) cells are relatively uncommitted or progenitor (e.g., pluripotent) cells. EBD cells, while not immortal, display long-term proliferation in culture... | 09/14/2010 |
| 7572632 | Dry powder cells and cell culture reagents and methods of production thereof Methods and compositions involving nutritive media, media supplements, media subgroup and buffer formulations are provided. Powder buffer formulations that produce particular ionic and pH conditions upon reconstitution with a solvent are also disclosed. Methods of p... | 08/11/2009 |
| 7439064 | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferring, insuli... | 10/21/2008 |
| 7429483 | Use of nerve growth factor for the storage, culture or treatment of cornea The nerve growth factor (NGF) is used for the storage of corneas in culture, for the production and the storage in vitro of single cell populations of the corneal morphological and functional unit (i.e. epithelium, stroma/keratocytes and endothelium) and of the conj... | 09/30/2008 |
| 7416887 | Methods for use of MPL ligands with primitive human stem cells Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin supports both mega... | 08/26/2008 |
| 7374934 | Cell populations and methods of production thereof The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth f... | 05/20/2008 |
| 7374937 | Isolation and expansion of human marrow stromal cells The invention includes in vitro methods of inducing and enhancing proliferation of human marrow stromal cells for use in, for example, gene therapy and transplantation methods. The invention also includes a method of assessing the expandability (i.e., proliferative ... | 05/20/2008 |
| 7371575 | Process for ex vivo formation of mammalian bone and uses thereof The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue culture conditions and factors resulting in the formation of bone ce... | 05/13/2008 |
| 7371576 | CD56 positive human adult pancreatic endocrine progenitor cells The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into insulin producing cells or into insulin producing cell aggregates. ... | 05/13/2008 |
| 7354730 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 04/08/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7344884 | Peptides promoting cell adherence, growth and secretion The present invention provides specific peptides identified as having cell adhesion, growth, expression or secretion-enhancing activities. Many of the peptides of the invention may be produced in large quantity by such means as chemical synthesis or recombinant DNA ... | 03/18/2008 |
| 7329726 | Physiologically active peptides A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in... | 02/12/2008 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7304129 | Peptides that stimulate cell survival and axon regeneration Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa at position 3 represents any amino acid and Xaa at p... | 12/04/2007 |
| 7294481 | Method for producing recombinant proteins A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of a tumor necrosis factor receptor fused to the Fc portion of an immun... | 11/13/2007 |
| 7279301 | Methods of determining deficiencies in intracellular levels on cysteine and glutathione The present invention provides a method for determining an antioxidant deficiency in a lymphocyte by determining the level of intracellular cysteine in the lymphocyte by measuring lymphocyte growth in a serum-free cell culture medium comprising cumene hydroperoxide ... | 10/09/2007 |
| RE39792 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 08/21/2007 |
| 7252799 | Methods for sterilizing preparations containing albumin Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, na... | 08/07/2007 |
| 7247478 | Keratinocytes useful for the treatment of wounds The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds. ... | 07/24/2007 |
| 7247424 | Screening method for a substance having hypoglycemic activity by using STAT-induced inhibitor of STAT function-1 The present invention discloses a screening method for a substance, which could be a therapeutic agent for diabetes with insulin resistance through regulating a function of a molecule involved in insulin signaling pathway. More specifically, the present invention di... | 07/24/2007 |
| 7247481 | Process for culturing cells sampled for biopsy The present invention provide: a novel process for culturing animal cells and a kit for culturing animal cells, in which, even if the number of cells as sampled for biopsy is extremely small, the proliferation can sufficiently be maintained so as to enable to carry ... | 07/24/2007 |
| 7229826 | Process for ex vivo formation of mammalian bone and uses thereof The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue culture conditions and factors resulting in the formation of bone ce... | 06/12/2007 |
| 7220538 | Composition for maintaining organ and cell viability The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs suc... | 05/22/2007 |
| 7217294 | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joi... | 05/15/2007 |
| 7217570 | Organotypic intestinal culture and methods of use thereof An organotypic culture comprises an artificial stroma overlayed with epithelial cells isolated from a human colon or intestine. The stroma comprises a mixture of collagen and human fibroblasts isolated from a human colon or intestine. The culture contains a factor t... | 05/15/2007 |
| 7192768 | Synchronization of the cytoplasmatic and the nuclear maturation of oocytes The present invention relates to a method for in vitro maturation of oocytes comprising the steps of: (a) culturing one or more GV oocytes in a culture medium, the culture medium comprising a nuclear maturation inhibiting substance and comprising one or... | 03/20/2007 |
| 7189567 | Method of culturing human chondrocytes This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human chondrocytes together with perichondral cells in the chondrogenic stage, as fee... | 03/13/2007 |
| 7169605 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 01/30/2007 |
| 7166277 | Remyelination of neurons using multipotent neural stem cell progeny The invention provides methods for producing myelin forming cells from multipotent self-renewing central nervous system neural stem cells as well as methods of using one or more cells from a multipotent self-renewing central nervous system neural stem cell populatio... | 01/23/2007 |
| 7153686 | Compositions of enriched central nervous system stem cell and progenitor cell populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. ... | 12/26/2006 |
| 7125658 | Small protein that interacts with a ribonucleotide reductase subunit and uses thereof The present invention provides for an isolated Sml1 protein or a homologue thereof. The present invention also provides for a screening assay for identifying compounds that are capable of reducing the division rate of a cell by altering an interaction between a ribo... | 10/24/2006 |
| 7115418 | Methods of proliferating undifferentiated neural cells The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents which affect proliferation differentiation survival phenotype or func... | 10/03/2006 |
| 7101710 | Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid A method of harvesting mesenchymal stem cells from human amniotic fluid uses a two-stage culture protocol comprising culturing human amniocytes and then culturing mesenchymal stem cells. For culturing human amniocytes, primary amniocyte cultures are set up using rou... | 09/05/2006 |
| 7101711 | Phosphoepoxides, method for making same and uses The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3, ... | 09/05/2006 |
| 7097832 | Intramyocardial injection of autologous bone marrow A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and/or administered in combination with a pharmaceutical drug, protein, gene or other fa... | 08/29/2006 |
| 7078189 | Preparing membrane receptors from extracellular baciloviruses Method of producing a recombinant membrane receptor protein by introducing a baculovirus expression vector encoding the membrane receptor protein into a host cell, culturing the resultant host cell for a sufficient time to permit expression of the membrane receptor ... | 07/18/2006 |
| 7078224 | Cell concentration and lysate clearance using paramagnetic particles Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of cells or a homogenate of mammalian tissue. Methods are also disclosed for... | 07/18/2006 |
