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| Number | Title | Issue Date |
| 8163555 | Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication wi... | 04/24/2012 |
| 8148152 | Method for the preparation of embryoid bodies (EBs) and uses thereof Provided are means and methods for producing embryoid bodies (EBs) from multi- or pluripotent cells. In particular, a method of generating embryoid bodies (EBs) is described comprising agitation of a liquid suspension culture of multi- or pluripotent cells in a cont... | 04/03/2012 |
| 8137971 | Preparing a population of human late stage motor neuron progenitor cells Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% v... | 03/20/2012 |
| 8124410 | Methods of finding, selecting and studying cells in heterogeneous co-cultures Co-cultures of heterogeneous cell populations in a diffusion-constrained microenvironment and methods for co-culturing are disclosed. ... | 02/28/2012 |
| 8114669 | Cell culture A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two o... | 02/14/2012 |
| 8105834 | Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using same The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of sof... | 01/31/2012 |
| 8071381 | Systems and methods for screening pharmaceutical chemicals A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A meth... | 12/06/2011 |
| RE41974 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 11/30/2010 |
| 7816138 | Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue Methods and apparatus for a bioreactor system for growing cells are provided. The bioreactor system includes a reaction chamber for cultivating harvested tissue in a culture medium, and a hydrodynamic apparatus connected to the reaction chamber that generates a cycl... | 10/19/2010 |
| 7790456 | Scalable process for cultivating undifferentiated stem cells in suspension The invention relates to a process for cultivating undifferentiated stem cells in suspension and in particular to a method for cultivating stem cells on microcarriers in vessels. The method enables stem cells to be cultivated in a scalable process for the first time... | 09/07/2010 |
| 7754484 | Use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultures The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of p... | 07/13/2010 |
| 7718430 | Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication wi... | 05/18/2010 |
| 7682827 | Microelectronic positioning for bioparticles The present invention provides a method for microelectronic positioning bioparticles, which utilizes dielectric and non-contact electrical force of cell themselves associated with multi-phase electrical signals to attain uniformity of distribution of the bioparticle... | 03/23/2010 |
| 7601535 | Cell culture media for enhanced protein production Culture media for in vitro cell culture which contain substantially saturated amounts of selected amino acids improve protein production, constrain cell growth and extend cell longevity, methods for the production and use of such media, and systems for the productio... | 10/13/2009 |
| 7514260 | Feeder independent extended culture of embryonic stem cells Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if an an... | 04/07/2009 |
| 7439037 | Use of aminoglycoside resistance gene Use of aminoglycoside resistance gene product for achieving high-density growth of animal cells. ... | 10/21/2008 |
| 7413904 | Human embryonic stem cells having genetic modifications This disclosure provides a system for obtaining genetically altered primate pluripotent stem (pPS) cells. The role of the feeder cells is replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned medium. The cells can be... | 08/19/2008 |
| 7410787 | Diagnosis of Whipple's disease The invention relates to a method for in vitro seriological diagnosis of Whipple's disease, whereby the bacteria responsible for the disease are isolated and established in a culture and brought into contact with the serum or biological fluid of an infected patient.... | 08/12/2008 |
| 7399632 | Mesenchymal precursor cell A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 07/15/2008 |
| 7361506 | Differentiation of specialized dermal and epidermal cells into neuronal cells Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting of keritinocytes and/or melanocytes; taking a sample of tissue from th... | 04/22/2008 |
| 7351584 | Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-... | 04/01/2008 |
| 7348176 | Chamber with adjustable volume for cell culture and organ assist The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates san... | 03/25/2008 |
| 7344881 | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least... | 03/18/2008 |
| 7323333 | Materials and methods for regulating process formation in cell culture The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In ... | 01/29/2008 |
| 7314759 | Continuous fluid sampler and method A method of using an aseptic sampling arrangement. The sampling arrangement includes a septum cartridge and a securing element for use with a fluid enclosure. A locking arrangement is provided to allow selective access to the septum cartridge and the securing elemen... | 01/01/2008 |
| 7312065 | of European origin and vaccines, diagnostic agents and methods of use thereof The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method ... | 12/25/2007 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7304129 | Peptides that stimulate cell survival and axon regeneration Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa at position 3 represents any amino acid and Xaa at p... | 12/04/2007 |
| 7303769 | Method for purifying pluri-differentiated mesenchymal progenitor cells There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such ... | 12/04/2007 |
| 7300789 | Bioreactor forming a rigid vessel The invention provides a bioreactor (10) for the culture of animal, vegetable, microbial of algal cells of their co-cultures, of the type including a body (12) which delimits an internal volume (14) capable of holding a culture liquid (16) and a gas volume (17) abov... | 11/27/2007 |
| 7300773 | Production of TNFR-Ig An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/27/2007 |
| 7294484 | Production of polypeptides An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/13/2007 |
| 7294481 | Method for producing recombinant proteins A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of a tumor necrosis factor receptor fused to the Fc portion of an immun... | 11/13/2007 |
| 7291484 | Processes for culturing E1-immortalized cells to increase product yields The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® (human embryonic retina) cells, to improve product yields from such cells. Feed strategies for such cells and c... | 11/06/2007 |
| 7291451 | Modulation of pericyte proliferation Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided. ... | 11/06/2007 |
| 7276371 | Stimulation of hematopoietic cells in vitro Methods, compositions, and devices for stimulating the number and/or differentiation of hematopoietic cells in vitro are provided. The methods involve contacting the hematopoietic cells with an inhibitor of dipeptidyl peptidase (DPIV) in the absence of exogenously p... | 10/02/2007 |
| 7272981 | Aseptic fluid sampler and method An aseptic sampling arrangement that provides selective access to an interior of a fluid enclosure. The sampling arrangement includes a septum cartridge and a securing element for use with the fluid enclosure. A locking arrangement is provided to allow selective acc... | 09/25/2007 |
| RE39792 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 08/21/2007 |
| 7229826 | Process for ex vivo formation of mammalian bone and uses thereof The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue culture conditions and factors resulting in the formation of bone ce... | 06/12/2007 |
| 7220538 | Composition for maintaining organ and cell viability The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs suc... | 05/22/2007 |
