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| Number | Title | Issue Date |
| 7547547 | Bioprocess for producing uniform embryoid bodies from embryonic stem cells in a high density bioreactor The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES) cell-derived tissues. To counter this, the invention provides a novel bioproces... | 06/16/2009 |
| RE40555 | Preparation of agarose coated, solid agarose beads containing secretory cells Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and sec... | 10/28/2008 |
| 7329537 | Micro-pattern embedded plastic optical film device for cell-based assays In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a ... | 02/12/2008 |
| 7323323 | Preparation and xenotransplantation of porcine islets The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient m... | 01/29/2008 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7311926 | Biocomposite materials and methods for making the same A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide m... | 12/25/2007 |
| 7297331 | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 11/20/2007 |
| 7297538 | Encapsulated cell indicator system The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system... | 11/20/2007 |
| 7247481 | Process for culturing cells sampled for biopsy The present invention provide: a novel process for culturing animal cells and a kit for culturing animal cells, in which, even if the number of cells as sampled for biopsy is extremely small, the proliferation can sufficiently be maintained so as to enable to carry ... | 07/24/2007 |
| 7238526 | Methods and cell line useful for production of recombinant adeno-associated viruses Methods for efficient production of recombinant AAV employ a host cell which comprising AAV rep and cap genes stably integrated within the cell's chromosomes, wherein the AAV rep and cap genes are each operatively linked to regulatory sequences capable of directing ... | 07/03/2007 |
| 7229808 | Bioreactor The present invention relates to a process for producing a bioreactor using viable immobilized biological material and to the bioreactor itself. More particularly, the present invention relates to a process for producing a siliceous layer capable of biomass i... | 06/12/2007 |
| 7195912 | Hydrogel thin film containing extracellular matrix components The thin film of the invention comprises a hydrate of a vitrified gel containing one or more extracellular matrix components, which can be integrated with a retainer as required. A hydrogel thin film containing one or more extracellular matrix components such as thi... | 03/27/2007 |
| 7192769 | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exog... | 03/20/2007 |
| 7101545 | Method for using human intervertebral disc cells There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a growth factor, or a cytokine or a bioactive agent to form monolayer pr... | 09/05/2006 |
| 7056726 | membrane for encapsulation chamber of cells producing at least a biologically active substance and bioartificial organ comprising same The invention concerns a semipermeable chamber for encapsulation of cells producing at least a biological substance of interest, characterised in that it consists of a porous polycarbonate biocompatible film modified at the surface by generated polar sites and cover... | 06/06/2006 |
| 7041504 | Cancer cell-inhibiting culture medium produced by culturing restricted entrapped cancer cells Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 05/09/2006 |
| 6972194 | Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of treating diabetes mellitus. In the invention a new method of cultiva... | 12/06/2005 |
| 6958148 | Linkage of agents to body tissue using microparticles and transglutaminase Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the group... | 10/25/2005 |
| 6893634 | Encapsulated cells producing cytochrome P450 The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the treatment of cancer or any other relevant disease with said capsules a... | 05/17/2005 |
| 6872569 | In vitro production of haploid germ cells The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method de... | 03/29/2005 |
| 6872387 | Three-dimensional hydrogel/cell system Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that make them suitable for a variety of uses, including uses for in vitro t... | 03/29/2005 |
| 6846675 | Skin substitutes and uses thereof The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior ... | 01/25/2005 |
| 6818230 | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 11/16/2004 |
| 6808705 | Agarose coated agarose beads containing cancer cells which produce cancer-cell proliferation-suppressing material Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 10/26/2004 |
| 6790441 | Sertoli cells as biochambers According to the present invention, there is provided a biological chamber system having a biochamber defined by outer walls of Sertoli cells. Also provided is a transplantation facilitator including a biochamber. A method of making biochambers by co-culturing facil... | 09/14/2004 |
| 6783964 | Microencapsulated pancreatic islet cells Methods of treating and forming biocompatible microcapsules that contain living cells are provided, to improve the function of the microcapsules. In particular, methods of treating islet cells or microcapsules containing islet cells are provided. Culture of isolated... | 08/31/2004 |
| 6780643 | Cancer cell-inhibiting culture medium produced by culturing restricted entrapped cancer cells Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 08/24/2004 |
| 6730314 | Culturing encapsulated chondrocytes under reduced oxygen partial pressure to produce cartilage implants A process is provided for the production of a human cartilage implant from chondrocytes cultured in vitro, which come as close as possible to the original with respect to their biochemical composition and biomechanical properties. Up to 20% vol. of human serum is us... | 05/04/2004 |
| 6713293 | Encapsulated cells containing an amplified expression vector as a drug delivery device The present invention provides a drug delivery device comprising encapsulated cells that contain multiple copies of an expression cassette. The drug delivery device of the present invention is useful to supply an animal, including a human, with a therapeutically des... | 03/30/2004 |
| 6703017 | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures The subject invention concerns new methods which make it possible, for the first time, to grow functional islet-producing stem cells (IPSCs), islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in in vitro cultures. The subject invention also conc... | 03/09/2004 |
| 6699470 | Mesh-gel constructs for cell delivery containing enzymes and/or enzyme inhibitors to control gel degradation A cell delivery device is prepared comprising a controllable degradable gel phase, meshed within a polymer substrate for use in tissue-engineering. The gel phase comprises a degradable, natural or synthetic polymer, and includes a suspension of living cel... | 03/02/2004 |
| 6680184 | Encapsulating liquid with hydrocolloid membrane stable from about -20 to 90 degrees C without bursting A temperature-stable droplet is provided containing a temperature-stable hydrocolloid membrane. The hydrocolloid membrane encapsulates a liquid that contains at least one enzyme, a cell, a biological agent, a pharmaceutical agent, an immunological agent, ... | 01/20/2004 |
| 6649384 | System and method for encapsulating biological material by applying electrostatic charge to capsules A method and system for the effective and consistent encapsulation of viable (i.e., living or physiologically active) biological material (preferably, pancreatic islets also known as islets of Langerhans) with a polymeric material (preferably, a biocompat... | 11/18/2003 |
| 6641832 | Increasing blood flow to tissue with angiogenic material containing polymer and vascularizing compound An angiogenic material is prepared which promotes extensive vascularization when implanted in animal tissue. The angiogenic material is preferably used in microcapsule coatings and microspheres for implantation in animals. In microcapsules, the angiogenic... | 11/04/2003 |
| 6632446 | Coating substrates by polymerizing macromers having free radical-polymerizable substituents Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 10/14/2003 |
| 6627422 | Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may be formed of a plurality of monofilaments twisted into yarn... | 09/30/2003 |
| 6616912 | Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells A bi-component microporous hollow fiber membrane structure is provided for in vivo propagation of cells and use in testing of the effect of medical treatments on cells within the structure. The structure has an inner structure fabricated from a first bio-... | 09/09/2003 |
| 6592886 | Producing stable cross-linked alginate gel by binding surplus cations with anions A stable cross-linked alginate gel such as in the form of alginate gel beads encapsulating transplant materials is produced by binding surplus multivalent cations remaining after cross-linking alginate with the cations. A cross-linked alginate gel contain... | 07/15/2003 |
| 6582391 | Hybrid matrix implants and explants An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin (a) a plurality of vertebrate cells; and (b) a plurality of microspheres each of which consists primarily of one or more of the following mat... | 06/24/2003 |
| 6558665 | Encapsulating particles with coatings that conform to size and shape of the particles Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of different densities are provided in a container as upper and... | 05/06/2003 |
