Did You Know...
...that the Eveready Battery began as an invention called the "electric flowerpot," which was a tube with a battery and light bulb inside? The idea was to fasten this gizmo to the side of a flowerpot so it would illuminate the flowers from the bottom. The idea died on the vine and the businessman who licensed the flower pot, Conrad Huber, was left with a pile of useless tubes -- until he found a way to market them as batteries to light the world!
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| Number | Title | Issue Date |
| 7964402 | Methods for culture and production of single cell populations of human embryonic stem cells We used Accutase™, a commercially available cell detachment solution, for single cell propagation of pluripotent hESCs. Unlike trypsin dissociation, Accutase treatment does not significantly affect the plating efficiency of hESC dissociation into single cells. Cul... | 06/21/2011 |
| 7547546 | Progenitor cells from wharton's jelly of human umbilical cord Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC−/− progenitor cells, and is useful to grow and repair human tissues inclu... | 06/16/2009 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7250294 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells This invention provides populations of neural progenitor cells and differentiated neurons, obtained by culturing pluripotent cells in special growth cocktails. The technology can be used to produce progenitors that proliferate through at least ˜40 doublings, while ... | 07/31/2007 |
| 7166477 | Muscle sample prepared for prion assay A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a complexing agent which forms a complex with a higher specific gravit... | 01/23/2007 |
| 7109028 | Methods of isolating hepatic progenitors This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming a... | 09/19/2006 |
| 7049141 | Use of collagenase in the preparation of neural stem cell cultures The invention provides a method for using collagenase to dissociate neural stem cells in neural stem cell cultures. The collagenase treatment results in an increased cell viability and an increased number of proliferated neural stem cells over time. ... | 05/23/2006 |
| 7045349 | Method of islet isolation using process control Advanced Islet Separation Technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic islets in a tissue suspension in physiologic process solution, utili... | 05/16/2006 |
| 6900051 | Process for obtaining mammalian insulin secreting cells in vitro and their uses The present invention relates to a process for obtaining mammalian insulin secreting cells in vitro, characterized in that it contains the following steps: a) preparation of the mammalian pancreatic tissues by removal of a pancreas, b) dissociation of the pancreatic... | 05/31/2005 |
| 6869771 | Method for distributing equal volumes of attached confluent living cells A method for distributing an equal volume of attached confluent living cells in each well of a multi-well plate used in a bioassay, comprising the following steps: (a) growing attached living cells on a medium until the cells are confluent; (b) treating the a... | 03/22/2005 |
| 6833270 | Apparatus and method for isolating cells from organs An apparatus and method for extracting cells from organs in which a digestion chamber includes at least one inlet and at least one outlet, and a separator for retaining the organ and permitting the cells and the physiologically compatible medium to exit the outlet. ... | 12/21/2004 |
| 6825027 | Method of production of purified hepatitis a virus particles and vaccine preparation The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present invention is also directed to an HAV vaccine composition comprising a pr... | 11/30/2004 |
| 6585969 | Non-viable keratinocyte cell composition or lysate for promoting wound healing Cultures of keratinocyte cells are provided which are free from nonautologous fibroblasts and organ extracts, and which have a high speed of cell amplification for a minimum seeding density. The cultures can be cryopreserved in a buffered isotonic medium ... | 07/01/2003 |
| 6489164 | Isolation of cells from organ tissue using sonication A method for isolating specific viable cell types from surrounding organ tissue is provided. The method entails the use of sonication in conjunction with tissue dissociating agents to free the cells of interest. A specific application of the method is the... | 12/03/2002 |
| 6383805 | Epithelial cell cultures for in vitro testing A method and a medium for culturing epithelial cells of both normal and malignant origin is provided. The method entails physically disaggregating tissue samples, placing the resulting fragments onto a surface comprised of basement membrane matrix compone... | 05/07/2002 |
| 6365405 | Compositions of chondrocytes, preparation and utilization This invention concerns compositions of chondrocytic cells, notably human ones, and the methods for preparing and using them. More specifically, the invention describes the production of autologous human chondrocyte suspensions, employing recombinant enzy... | 04/02/2002 |
| 6242252 | Hepatic progenitors and method of isolating same This invention relates to methods of isolating hepatic progenitors utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatic progenitors and to a method of treating liver dysfunction as well a... | 06/05/2001 |
| 6238922 | Use of collagenase in the preparation of neural stem cell cultures The invention provides a method for using collagenase to dissociate neural stem cells in neural stem cell cultures when passaging aggregated neural stem cells. The collagenase treatment results in an increased cell viability and an increased number of pro... | 05/29/2001 |
| 6168944 | Methods for cultivating cells and propagating viruses This invention relates to methods for the cultivating cells, and in particular to methods for propagating recombinant viruses for gene therapy.... | 01/02/2001 |
| 6162643 | Hepes based basal nutrient medium for the isolation and culturing of stem cells Novel media and methods are disclosed for the growth of stem cells. The media are serum-free, companion cell or feeder layer free and organotypic, matrix free solutions for the isolation and cultivation of clonally competent basal epithelial cells. The me... | 12/19/2000 |
| 6146891 | Methods for cultivating cells and propagating viruses This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses.... | 11/14/2000 |
| 6107543 | Culture of totipotent embryonic inner cells mass cells and production of bovine animals The use of totipotent embryonic stem cells to provide substantially identical cells for embryo cloning techniques is described. The method includes the culture of loose suspensions of inner cell mass cells of bovine animals to retrieve large populations o... | 08/22/2000 |
| 5994619 | Production of chimeric bovine or porcine animals using cultured inner cell mass cells Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substan... | 11/30/1999 |
| 5925531 | Human bone marrow endothelial cell line and methods of use thereof The present invention provides immortalized human bone marrow endothelial cells which are useful for the study of tumor metastasis. In particular, the human bone marrow endothelial cell lines provided by the invention provide an in vitro model system for ... | 07/20/1999 |
| 5906934 | Mesenchymal stem cells for cartilage repair It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges f... | 05/25/1999 |
| 5905042 | Cultured inner cell mass cell lines derived from bovine or porcine embryos Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substan... | 05/18/1999 |
| 5888705 | Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo A method of inducing the proliferation and/or differentiation of human adult pancreatic cells entails contacting primary cultures of such cells with Hepatocyte Growth Factor/Scatter Factor (HGF/SF), thereby inducing a proliferation of ଲ-epithelial c... | 03/30/1999 |
| 5879939 | Isolation of cells from organ tissue using sonication A method for isolating specific viable cell types from surrounding organ tissue is provided. The method entails the use of sonication in conjunction with tissue dissociating agents to free the cells of interest. A specific application of the method is the... | 03/09/1999 |
| 5866167 | Non-viable total keratinocyte lysate for promoting wound healing Cultures of keratinocyte cells are provided which are free from nonautologous fibroblasts and organ extracts, and which have a high speed of cell amplification for a minimum seeding density. Preferably, a culture contains no more than about 10% autologous... | 02/02/1999 |
| 5855620 | Matrix substrate for a viable body tissue-derived prosthesis and method for making the same Disclosed is a process for treating body tissues such as vascular structures to remove barriers to recellularization before and after implantation in a human host. The body tissue, for example a heart valve, is subjected to a hypotonic/hypertonic treatmen... | 01/05/1999 |
| 5851833 | Neomorphogenesis of urological structures in vivo from cell culture Methods and artificial matrices for the growth and implantation of urological structures and surfaces are disclosed in which urothelial cells are grown in culture on biodegradable, biocompatible, fibrous matrices formed of polymers, such as polyglycolic a... | 12/22/1998 |
| 5827735 | Pluripotent mesenchymal stem cells and methods of use thereof A scar inhibitory factor protein isolate from mammalian basement membranes is provided that inhibits lineage commitment and differentiation of stem cells in vitro and in vivo. The protein isolate is characterized by its ability to inhibit stem cell commit... | 10/27/1998 |
| 5814511 | Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics Described is a substantially purified human breast epithelial cell (Type I HBEC) displaying the following characteristics: variable cell shape; smooth cell colony boundary; deficiency in gap junctional intercellular communication; positive expression of e... | 09/29/1998 |
| 5637486 | Methods of identifying potentially therapeutically effective agents and cell strains for use therein The present invention is to a method of screening agents for potential therapeutic efficacy. The method comprises exposing a cell strain that is sensitive to apoptotic agents to known apoptotic agents and to a potential therapeutic agent. The cell strain ... | 06/10/1997 |
| 5622857 | High performance cell culture bioreactor and method A high performance hollow fiber bioreactor having concentric hollow fiber bundles: a central hollow fiber bundle supplies media, and an outer array supplies oxygen needed for cell culture. Useful to expand therapeutic cells such as stem cells ex vivo, and... | 04/22/1997 |
| 5100799 | Method for releasing cell cultures from microcarriers This invention relates to a method for releasing cell cultures from microcarriers in which a trypsin solution is directed through a container with the microcarriers therein in a flow-through process. The released cells are immediately withdrawn from the c... | 03/31/1992 |
| 5081030 | Release of cells from affinity matrices The present invention comprises a process for release from the cell-receptor complex of positively selected cells in viable, functional condition, where a ligand involved in the particular receptor-ligand interaction utilized for the affinity purification... | 01/14/1992 |
| 4556639 | Method and apparatus for dislodging cultured cells A method for dislodging cultured cells has the steps of preparing a culture container which has a growing surface on which cultured cells are grown, and which is filled with a culture solution in contact with the cultured cells, supporting the culture con... | 12/03/1985 |
| 4339537 | Method of culturing biological substances Biological substances such as tissues, cells, vaccines and viruses are cultured by the steps of: introducing a culture solution having the substances suspended therein into a closed culture vessel having a plurality of disc-like implantation plates arrang... | 07/13/1982 |
| 4304866 | Transplantable sheets of living keratinous tissue A method of producing transplantable sheets of living keratinous tissue by culturing keratinocytes in a culture vessel and subsequently enzymatically detaching a sheet of keratinous tissue employing an enzyme, such as Dispase, is disclosed herein.... | 12/08/1981 |
