Bizarre Patents
A method of swing on a swing is disclosed, in which a user positioned on a standard swing suspended by two chains from a substantially horizontal tree branch induces side to side motion by pulling alternately on one chain and then the other.
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| Number | Title | Issue Date |
| 8188059 | Compounds and methods for modulating expression of GCGR The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or prot... | 05/29/2012 |
| 8183217 | Methods and means for obtaining modified phenotypes Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-... | 05/22/2012 |
| 8178348 | Chimeric antisense oligonucleotides of arabinofuranose analogue and deoxyribose nucleotides The present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynt... | 05/15/2012 |
| 8173595 | Methods and compositions for the inhibition of thrombus formation The present invention is directed to anti-platelet peptides that may be used in various methods for the treatment or prophylaxis of thrombosis. More specifically, the specification describes methods and compositions for making and using compositions GPIbα fragments... | 05/08/2012 |
| 8173612 | Chemotherapy involving antisense oligonucleotides for preventing and/or treating pulmonary fibrosis The invention provides, in the treatment of malignant tumors, antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene, in combination with a chemotherapy drug, typically bleomycin, cyclophosphamide, or methotrexate,... | 05/08/2012 |
| 8168603 | G-quartet oligonucleotides that target hypoxia-inducible factor 1-α (HIF1α) The present invention concerns particular G-quartet oligonucleotides that are employed for the treatment and/or prevention of cancer. In specific cases, the G-quartet oligonucleotides inhibit HIF-1α. ... | 05/01/2012 |
| 8168428 | Method to modulate hematopoietic stem cell growth The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC ... | 05/01/2012 |
| 8158597 | Modulation of diacylglycerol acyltransferase 1 expression Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 1. Methods of using these compounds for m... | 04/17/2012 |
| 8153596 | Use of SH2 STAT3/STAT1 peptidomimetics as anticancer drugs The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display... | 04/10/2012 |
| 8143230 | Compounds and methods for modulating expression of PCSK9 The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or prot... | 03/27/2012 |
| 8138159 | Composition for inhibiting function of human Flt3 To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method. ... | 03/20/2012 |
| 8133874 | Oligonucleotide or its functional homologue, a composition comprising the same and a method of treating B cell neoplasm The invention provides an oligonucleotide with a sequence of SEQ ID NO: 1 or its functional homolgue, a composition comprising the same and a method for treating B cell neoplasm by using the oligonucleotide or its functional homologue or the composition comprising t... | 03/13/2012 |
| 8133679 | Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in... | 03/13/2012 |
| 8119403 | Disease model incorporation into an artificial immune system (AIS) The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endoth... | 02/21/2012 |
| 8119402 | Methods of inhibiting T1R1/T1R3 heteromeric umami taste receptors Methods of inhibiting umami taste receptors are provided. These methods comprise contacting T1R1/T1R3 umami taste receptors with a sweet-taste inhibitor that also inhibits both the T1R1/T1R3 umami taste receptor and the T1R2/T1R3 sweet taste receptor. ... | 02/21/2012 |
| 8119404 | Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including the... | 02/21/2012 |
| 8114850 | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperp... | 02/14/2012 |
| 8105831 | Parvoviral production of HLA homozygous cells The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells. ... | 01/31/2012 |
| 8105830 | Polyspecific binding molecules and uses thereof The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-ch... | 01/31/2012 |
| 8093046 | CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions The invention provides a recombinant multi-functional chimera of CVN and 12p1. Chimeras of CVN and 12p1 present a model for targeting gp120 at two discrete sites, by two different modes of inhibition and with increasing potency versus either component alone. A chime... | 01/10/2012 |
| 8067386 | Modulation of eIF4E-BP2 expression Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diag... | 11/29/2011 |
| 8067388 | Decoy-containing pharmaceutical compositions and method of using the same A pharmaceutical composition is provided for treatment and prevention of a disease caused by expression of a gene controlled by NF-κB or ets. The composition comprises at least one decoy and a pharmaceutically acceptable carrier. The decoy is an NF-κB decoy, an et... | 11/29/2011 |
| 8067237 | Scaffolds for cell transplantation A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident c... | 11/29/2011 |
| 8062889 | Methods of evaluating a test agent in a diseased cell model The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system... | 11/22/2011 |
| 8048672 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet polypeptides, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which ... | 11/01/2011 |
| 8039256 | Culturing method of mesenchymal stem cell To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord bloo... | 10/18/2011 |
| 8034615 | Method for treating autoimmune diseases and screening method for preventive or therapeutic agent for the same A screening method for a preventive or therapeutic agent for an autoimmune disease and/or for an apoptosis inhibitor, comprising determining retinoblastoma associated protein (RBAp48) production suppressing effect or RBAp48 production inhibitory effect of a sample. | 10/11/2011 |
| 8008074 | Compositions and methods for improving bone mass through modulation of receptors of PTH and fragments thereof The present invention relates to the discovery of novel receptors for the signaling of PTH and/or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are selected from the group consisting of LRP5/6, TGFβRII, BMPRII (long ... | 08/30/2011 |
| 7998740 | Cytokine induction of selectin ligands on cells Methods and compositions for treating cells with cytokines are provided herein. ... | 08/16/2011 |
| 7998739 | Methods of activating NKT cells Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate ex... | 08/16/2011 |
| 7993918 | Tumor suppression using placental stem cells The present invention provides methods of suppression of tumor cell proliferation and tumor growth using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on ... | 08/09/2011 |
| 7985588 | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an... | 07/26/2011 |
| 7968525 | Use of RNA interference to validate new termiticide target sites and a method of termite control Methods, matrix compositions and kits for increasing the mortality of termites (R. flavipes) and interfering with termite development using RNA interference techniques to target cellulase, lignocellulase, hexamerin, broad, farnesoic acid methyl transferase, c... | 06/28/2011 |
| 7964400 | Immune potentiating compositions of cancer cells A composition of matter is disclosed, comprising an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) for a time and under conditions sufficient to enhance the antigen presenting function of said cells. Also disclo... | 06/21/2011 |
| 7955851 | Culture of human embryonic stem cells on a matrix with TGFB1 and bFGF The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in... | 06/07/2011 |
| 7951785 | NFIA in glial fate determination, glioma therapy and astrocytoma treatment Disclosed herein are compositions comprising NFIA inhibitors, as well as methods of using the same to treat glioma and astrocytomas. ... | 05/31/2011 |
| 7943377 | Process for plasmid DNA fermentation Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermen... | 05/17/2011 |
| 7943568 | Antitumor agents Compounds and methods useful for the treatment of cancer in subjects in need of such treatment. The compounds are metabolites of the compound FK228 which have been identified as possessing HDAC inhibitory activity and anticancer properties. Further provided are comp... | 05/17/2011 |
| 7927872 | ALDOs as modifiers of the IGF pathway and methods of use Human ALDO genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of ALDO are... | 04/19/2011 |
| 7923245 | Medium for ES culturing The present invention discloses a medium for a serum-free medium capable of culturing ES cells for a long period while maintaining their undifferentiated state without using feeder cells, and a basal medium for producing the medium thus described. The basal medium o... | 04/12/2011 |
