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| Number | Title | Issue Date |
| 8148148 | Neural progenitor cell populations This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates diff... | 04/03/2012 |
| 8129184 | Cancer stem cell antigen vaccines and methods Method of stimulating an immune response (e.g., to treat cancer) include administering to a patient a composition including dendritic cells that present cancer stem cell antigens. Compositions including cancer stem cell antigens are also provided herein. ... | 03/06/2012 |
| 8101409 | Ultra-nanocrystalline diamond as a biomaterial for enhancing proliferation and differentiation of neural stem cells Compositions for promoting growth and/or differentiation of a stem cell are disclosed. The composition comprises: a) a diamond film; b) a stem cell cultured on the diamond film; and c) a medium bathing the stem cell. The stem cell may be a mammalian neural stem cell... | 01/24/2012 |
| 8043853 | Postnatal gut neural crest stem cells The present invention relates to compositions and methods employing postnatal (e.g., adult) neural crest stem cells. The stem cells are multipotent and differentiate when transplanted in vivo. Transplantation methods are provided for therapeutic, diagnostic, and res... | 10/25/2011 |
| 8030072 | Method of isolating epidermal neural crest stem cells The present invention describes novel methods for isolating a substantially pure cell population of non-embryonic epidermal neural crest stem cells from the bulge-region of mammalian hair follicles. Also disclosed is the substantially pure cell population of follicu... | 10/04/2011 |
| 7981863 | Treatment of Parkinson's disease with PDGF The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent th... | 07/19/2011 |
| 7943376 | Platelet derived growth factor (PDGF)-derived neurospheres define a novel class of progenitor cells The present invention is related to the discovery of a novel class of neural progenitor cells, which proliferate in response to platelet derived growth factor (PDGF) and differentiate into neurons and oligodendrocytes but not astrocytes. Progeny of the progenitor ce... | 05/17/2011 |
| 7807462 | Method for producing a functional neuron The present invention relates to the production of functional neurons from adult human mesenchymal stem cells using a retinoid. A retinoid, when used in the absence of a growth factor, transdifferentiates mesenchymal stem cells into functional neurons that exhibit s... | 10/05/2010 |
| 7795021 | Lineage restricted glial precursors from the central nervous system A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astro... | 09/14/2010 |
| 7785882 | Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them The present invention relates to an enriched or purified preparation of isolated hippocampal neural progenitor cells and progeny thereof. The present invention also relates to a method of separating neural progenitor cells from a mixed population of cell types from ... | 08/31/2010 |
| 7732201 | Method for production of neuroblasts A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, an... | 06/08/2010 |
| 7732200 | Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture The subject invention pertains to compositions and methods for culturing nerve tissue in vitro and nerve grafts produced using such methods. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disea... | 06/08/2010 |
| 7709255 | Nerve cells obtained by electric pulse treatment of ES cells It is an object of the present invention to apply a novel method of preparing neural cells from ES cells. The method of the present invention is characterized by the electric pulse treatment of differentiating ES cells. Nerve cells obtained by the method of the pres... | 05/04/2010 |
| 7666672 | Cell lines The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302. ... | 02/23/2010 |
| 7632678 | Cancer stem cells and uses thereof Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of being passaged in high frequency. These NB TICs have chromosomal abnormal... | 12/15/2009 |
| 7629169 | Methods for the production of platelet-derived growth factor-responsive neural precursor cells This invention provides platelet-derived growth factor-responsive neural precursor (PRP) cells and methods of producing such cells in vivo or in vitro. These cells can further be used to generate neurons, oligodendrocytes and/or astrocytes. ... | 12/08/2009 |
| 7595194 | Isolation of mammalian CNS glial-restricted precursor cells Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocy... | 09/29/2009 |
| 7544511 | Stable neural stem cell line methods A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible cultures of human and other mammalian neurons in commercially useful mass q... | 06/09/2009 |
| 7468277 | Enriched preparation of human fetal multipotential neural stem cells The present invention relates to a method of separating multipotential neural progenitor cells from a mixed population of cell types. This method includes selecting a promoter which functions selectively in the neural progenitor cells, introducing a nucleic acid mol... | 12/23/2008 |
| 7442545 | Neural colony forming assay A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a method for identifying neural stem cells or neural progenitor cells compri... | 10/28/2008 |
| 7439066 | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelo... | 10/21/2008 |
| 7435586 | Method of purification of cells The present invention relates generally to a method for the generation of a substantially homogeneous population of undifferentiated cells. More particularly, the present invention relates to the purification of a substantially homogeneous population of stem cells a... | 10/14/2008 |
| 7419827 | Cell lines Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-... | 09/02/2008 |
| 7419825 | Isolation of neural stem cells using gangliosides and other surface markers During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem c... | 09/02/2008 |
| 7419826 | Human schwannoma cell line In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7 genes. The cell line has a unique splice site mutation of the NF2 gene. T... | 09/02/2008 |
| 7416888 | Cell lines The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302. ... | 08/26/2008 |
| 7413898 | Cells and methods for estimation of effects on neurological dysfunction The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowt... | 08/19/2008 |
| 7410797 | Meningeal-derived stem cells Stem cell lines derived from meningeal tissue such as dura mater, pia mater, or arachnoid mater, are disclosed. In various embodiments, the stem cell lines include greater than 80%, greater than 90%, or greater than 99% of pluripotent meningeal-derived stem cells. I... | 08/12/2008 |
| 7405284 | Reducing cellular dysfunction caused by mitochondrial gene mutations A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitocho... | 07/29/2008 |
| 7393830 | Prolactin induced increase in neural stem cell numbers The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for l... | 07/01/2008 |
| 7381561 | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided. ... | 06/03/2008 |
| 7368115 | Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP) The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating polypetide (PACAP). In a preferred embodiment, additional growth factors are a... | 05/06/2008 |
| 7364921 | Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a... | 04/29/2008 |
| 7361505 | Multipotent neural stem cell compositions The invention provides in vitro cell culture compositions consisting of neurospheres and culture medium, wherein the neurospheres consist of undifferentiated cells that are nestin+, glial fibrillary acid protein (GFAP)−, neurofilament (NF) | 04/22/2008 |
| RE40209 | Cell potential measurement apparatus having a plurality of microelectrodes A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct measurements accurately and efficiently as well as can improve conve... | 04/01/2008 |
| 7323333 | Materials and methods for regulating process formation in cell culture The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In ... | 01/29/2008 |
| 7323334 | Screening and therapeutic methods relating to neurogenesis The invention provides methods of identifying compounds that modulate neurogenesis. The methods involve providing a compound that modulates prokineticin receptor signaling; contacting a neural stem or progenitor cell with the compound; and determining the ability of... | 01/29/2008 |
| 7320872 | Ependymal neural stem cells and method for their isolation The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis... | 01/22/2008 |
| 7314724 | Therapeutic applications of laminin and laminin-derived protein fragments Laminin and specific laminin-derived protein fragments are disclosed as potent inhibitors of Alzheimer's disease type amyloidoses. A specific region is identified within laminin which interacts with the Alzheimer's disease beta-amyloid protein and contributes to the... | 01/01/2008 |
| 7312025 | Methods and systems for extended in vitro culture of neuronal cells A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal... | 12/25/2007 |
