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| Number | Title | Issue Date |
| 6905831 | Real time measurement of cellular responses Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally-aided observation. These observations may be m... | 06/14/2005 |
| 6905875 | Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good ... | 06/14/2005 |
| 6905873 | Recombinant p53 adenovirus methods and compositions Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p... | 06/14/2005 |
| 6902929 | Retroviral vectors, methods for their preparation and their use for gene transfer into CD4-positive cells The invention relates to the production and use of retroviral vectors for cell specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine leukemia virus (MLV) and envelope proteins of human immunodeficiency v... | 06/07/2005 |
| 6900051 | Process for obtaining mammalian insulin secreting cells in vitro and their uses The present invention relates to a process for obtaining mammalian insulin secreting cells in vitro, characterized in that it contains the following steps: a) preparation of the mammalian pancreatic tissues by removal of a pancreas, b) dissociation of the pancreatic... | 05/31/2005 |
| 6900053 | Antisense modulation of fibroblast growth factor receptor 2 expression Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast gro... | 05/31/2005 |
| 6897063 | Accessory functions for use in recombinant AAV virion production Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producin... | 05/24/2005 |
| 6897064 | Cell or tissue-culturing carrier, and culturing method A cell or tissue-culturing carrier which can effectively regenerate an intended a cell or tissue, while suppressing an excessive growth of fibroblasts, and a method of culturing a cell or tissue by using the above carrier, the cell or tissue-culturing carrier wherei... | 05/24/2005 |
| 6897045 | Adeno-associated virus vectors The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste... | 05/24/2005 |
| 6897061 | Transdifferentiation of glial cells A process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate fetal or adult mammalian glial cells into multipotent cells. The multipotent cells may further be differentiated into particular types of nervous system cells, i... | 05/24/2005 |
| 6893871 | Human ovarian mesothelial cells and methods of isolation and uses thereof The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the microenvironment of the ovarian mesothelial cells, multiple passages are at... | 05/17/2005 |
| 6890754 | Epidermis/dermis equivalents and aged skin equivalents shaped therefrom An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen. An aged dermis equivalent, the epidermis equivalent obtained and methods of producing the aged skin and/o... | 05/10/2005 |
| 6887707 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the... | 05/03/2005 |
| 6887706 | Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b) propagating the stem cells, (c) forming embryoid bodies from the stem cel... | 05/03/2005 |
| 6887704 | Methods of controlling proliferation and differentiation of stem and progenitor cells A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as... | 05/03/2005 |
| 6884621 | Method and carrier for culturing multi-layer tissue in vitro The present invention provides method and carrier for culturing multi-layered tissue in vitro, wherein few amounts of tissue blocks and cells are positioned within a porous multi-layer carrier consisting of a cavity structure. By taking advantage of the structure of... | 04/26/2005 |
| 6884585 | Induction of beta cell differentiation in human cells by stimulation of the GLP-1 receptor The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured... | 04/26/2005 |
| 6881574 | Noninvasive detection of colorectal cancer and other gastrointestinal pathology A method for isolating viable, biologically substantially pure exfoliated fecal colonocytes at normal ambient temperature is described. Immunocoprocytes and inflammatory cells indicative of certain gastrointestinal conditions and a noninvasive method for detecting c... | 04/19/2005 |
| 6881413 | Humanized biomaterials, a process for their preparation and their applications The invention relates to humanized biomaterial comprising a porous biocompatible composite material customized and implanted with monocyte derived cells preferably with macrophages. ... | 04/19/2005 |
| 6878383 | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided. The composition comprises a biodegradable acellular matrix, and passa... | 04/12/2005 |
| 6878687 | Protein HMAAD57 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 04/12/2005 |
| 6878543 | Cultures of GFAP+ nestin+ cells that differentiate to neurons Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. T... | 04/12/2005 |
| 6878545 | Method for separating viable cells from cell suspensions The invention relates to a method of separating viable cells from cell suspensions using hydrocyclones, which method can, especially, be carried out continuously. ... | 04/12/2005 |
| 6872569 | In vitro production of haploid germ cells The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method de... | 03/29/2005 |
| 6863884 | Pseudotyped retroviral vectors The present invention provides pseudotyped retroviral vectors and packaging systems and methods of using such vectors for retroviral-mediated gene transfer. In particular, the present invention provides a retroviral packaging system that comprises at least two vecto... | 03/08/2005 |
| 6858582 | Composition containing porous microparticle impregnated with biologically-active compound for treatment of infection Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mammalian cells.... | 02/22/2005 |
| 6855519 | Methods for enhancing the production of interferon in cell culture Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-dependent kinas... | 02/15/2005 |
| 6852531 | Compositions and methods for reproducing and modulating mammalian messenger RNA decapping An in-vitro system in which mammalian messenger RNA decapping occurs is provided, for use in identifying modulators, deficiencies, and other aspects of the regulation of RNA turnover. ... | 02/08/2005 |
| 6852520 | DSP-2 dual-specificity phosphatase Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation... | 02/08/2005 |
| 6852515 | Stimulation of angiogenesis via enhanced endothelial expression of syndecan-4 core The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having ... | 02/08/2005 |
| 6846676 | In Vivo production and delivery of erythropoietin or insulinotropin for gene therapy The invention provides primary and secondary cells that are transfected with a nucleic acid molecule that encodes erythropoietin, clonal or heterogenous strains of such cells, and methods of producing these cell strains. ... | 01/25/2005 |
| 6846673 | Identification of human cell lines for the production of human proteins by endogenous gene activation A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a pro... | 01/25/2005 |
| 6846674 | Genetically modified fibroblast cells The invention relates to genetically modified fibroblast cells which comprise the following properties: (a) a gene, encoding a subunit of the transcription factor AP-1, of its genome is inactivated and/or a component, acting on the AP-1 transcription factor of the s... | 01/25/2005 |
| 6844192 | Adenovirus E4 protein variants for virus production A method of packaging a recombinant viral vector is carried out by: (a) providing a packaging cell, the packaging cell containing and expressing a nucleic acid encoding a mutant adenovirus E4orf6 protein, the E4orf6 protein containing at least one mutation that rend... | 01/18/2005 |
| 6841151 | Chondrocyte cell-lines The invention relates to chondrocytes and chondrocyte cell-lines for use especially in studying arthritic conditions and also for developing skeletal tissue for use in repair and/or replacement surgery, and the use of articular chondrocyte cell-lines which mineraliz... | 01/11/2005 |
| 6841150 | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combinat... | 01/11/2005 |
| 6838284 | Cell culture medium containing growth factors and L-glutamine The invention relates to a culture medium for culturing cells, in particular human cells in a process for tissue engineering bone. The medium comprises glucose, a mineral, a vitamin, a growth factor and L-glutamine, wherein the L-glutamine is present in a concentrat... | 01/04/2005 |
| 6838262 | Isolated DNA molecule encoding rank ligand Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof. ... | 01/04/2005 |
| 6838081 | Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CD14+ cells and precursors in bone... | 01/04/2005 |
| 6838235 | Methods for in vitro fertilization Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are ... | 01/04/2005 |
