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| Number | Title | Issue Date |
| 7319035 | Biological scaffolding material The invention provides methods of generating a natural, living biological matrix that can serve as, or form a part of, a natural biological scaffold. The matrix is generated by incubating together biological cells and cellular debris. Any naturally occurring cell ca... | 01/15/2008 |
| 7319034 | Modifications of apoptin Phosphorylated Apoptin is described. Apoptin is tumor-specifically phosphorylated and part of the Apoptin apoptotic pathway in tumor cells is elucidated. New therapeutic possibilities, for example, novel therapeutic compounds that can work alone or, sequentially to,... | 01/15/2008 |
| 7316897 | Process, device and reagent for cell separation A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, including treating the biological specimen to modify in a differential manner selected rare cells and other cells and causing differential migrat... | 01/08/2008 |
| 7316927 | Culture of goblet cells The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention... | 01/08/2008 |
| 7316896 | Egg freezing and storing tool and method An egg freezing and storing instrument has an egg freezing and storing tube made of a liquid nitrogen-resistant material; and a metal cylindrical protection member for protecting the tube. The tube has a body part; and an egg-storing small-diameter part having an in... | 01/08/2008 |
| 7312065 | of European origin and vaccines, diagnostic agents and methods of use thereof The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method ... | 12/25/2007 |
| 7311904 | Tissue matrices comprising placental stem cells, and methods of making the same A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tis... | 12/25/2007 |
| 7309589 | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing A method for identifying an RNA form of a bacteria, comprising reverse transcribing RNA material; conducting PCR using primers for a first highly conserved genetic sequence generic of the bacteria; conducting nested PCR using primers for a second highly conserved ge... | 12/18/2007 |
| 7309232 | Methods for treating dental conditions using tissue scaffolds The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA ... | 12/18/2007 |
| 7306943 | Keratinocytes useful for the treatment of wounds The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds. ... | 12/11/2007 |
| 7303906 | Competent bacteria The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced... | 12/04/2007 |
| 7303912 | Cultures of GFAP nestin cells that differentiate to neurons Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. T... | 12/04/2007 |
| 7303769 | Method for purifying pluri-differentiated mesenchymal progenitor cells There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such ... | 12/04/2007 |
| 7297538 | Encapsulated cell indicator system The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system... | 11/20/2007 |
| 7297539 | Medium for growing human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 11/20/2007 |
| 7297331 | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for ... | 11/20/2007 |
| 7294509 | Pre-adipose cell lines This invention relates to new immortalized human pre-adipose cell lines capable of differentiating into adipose cells and methods of obtaing the immortalized cells. In particular, the present invention pertains to immortalized pre-adipocyte cell lines derived from w... | 11/13/2007 |
| 7294508 | Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, and removing the inner cell m... | 11/13/2007 |
| 7291597 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral bl... | 11/06/2007 |
| 7288521 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA, VEGFB, PLGF, VEGF121, VEGF145, VEGF165, VEGF... | 10/30/2007 |
| 7285646 | Ultrapure transferrin for pharmaceutical compositions The present invention relates to an ultrapure human transferrin, and to methods for manufacturing the ultrapure transferrin. The transferrin may be holo-, apo- or at any desired degree of iron saturation. The invention further relates to the use of ultrapure transfe... | 10/23/2007 |
| 7285383 | Method for selective inactivation of viral replication Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determini... | 10/23/2007 |
| 7282366 | Hepatocytes for therapy and drug screening made from embryonic stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 10/16/2007 |
| 7279330 | Method for identifying modulating compounds of neurotransmitters A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compo... | 10/09/2007 |
| 7270810 | Veto cells effective in preventing graft rejection and devoid of graft versus host potential A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b) administering to the recipient a dose including non-alloreactive anti-third part... | 09/18/2007 |
| 7267981 | Human foreskin fibroblasts for culturing ES cells A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith. ... | 09/11/2007 |
| 7262288 | Nucleic acids encoding human telomerase reverse transcriptase and related homologs The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 08/28/2007 |
| 7259015 | Vector system Provided are retroviral vector genomes and vector systems comprising the genomes. In particular, a retroviral vector genome comprising two or more NOIs, operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more... | 08/21/2007 |
| 7259011 | Pluripotent adult stem cells The invention relates to isolated human pluripotent adult stem cells which express CD13, CD34, CD56 and CD117, and which do not express CD1O, which are capable of differentiating in all three germ lineages and differentiated cells derived therefrom. ... | 08/21/2007 |
| 7256042 | Process for making hepatocytes from pluripotent stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 08/14/2007 |
| 7252996 | Ancillary composition for the preparation of committed mature dentritic cells The invention consists in the use of a maturation agent comprising a mixture of ribosomal and/or membrane fractions for the preparation of mature dendritic cells from immature dendritic cells. ... | 08/07/2007 |
| 7250293 | Complementing cell lines A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid human cells transformed by adenovirus E1 sequences either operatively ... | 07/31/2007 |
| 7250292 | Hypertonic reduction of chilling injury This invention relates generally to cryopreservation and a method for preventing injury caused by cooling and warming of tissue and for reducing the toxicity of vitrification solutions. The present method achieves reduction or elimination of injury by increasing the... | 07/31/2007 |
| 7250294 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells This invention provides populations of neural progenitor cells and differentiated neurons, obtained by culturing pluripotent cells in special growth cocktails. The technology can be used to produce progenitors that proliferate through at least ˜40 doublings, while ... | 07/31/2007 |
| 7247478 | Keratinocytes useful for the treatment of wounds The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds. ... | 07/24/2007 |
| 7247481 | Process for culturing cells sampled for biopsy The present invention provide: a novel process for culturing animal cells and a kit for culturing animal cells, in which, even if the number of cells as sampled for biopsy is extremely small, the proliferation can sufficiently be maintained so as to enable to carry ... | 07/24/2007 |
| 7247427 | Leptin assay The invention provides a method for determining the presence of leptin in a sample. ... | 07/24/2007 |
| 7247477 | Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells There is provided a simplified and inexpensive method for the in-vitro identification, isolation and culture of human vasculogenic progenitor cells. The method and the progenitor cells isolated thereby can be used for in-vitro vascular engineering, treatment of cong... | 07/24/2007 |
| 7247480 | Method for producing dendritic cells Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of pro... | 07/24/2007 |
| 7244616 | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced express... | 07/17/2007 |
