Bizarre Patents
Behavior Modification Wristwatch
A wristwatch including a watch band and a watch body having an octagon shaped perimeter and being red in color and having the word STOP thereon to resemble a stop sign.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6737054 | Myocardial grafts and cellular compositions useful for same Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the he... | 05/18/2004 |
| 6737051 | Cell compositions containing macrophages, presenting anti-infectious and hematopoietic properties The invention relates to a cell composition containing macrophages, presenting anti-infectious and hematopoietic properties. More particularly, the invention relates to a cell composition containing macrophages, myeloid cells and progenitors; said cell compositions ... | 05/18/2004 |
| 6733971 | Method for identifying an agent that affects a hedgehog signaling pathway The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provi... | 05/11/2004 |
| 6730507 | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration This invention responds to a long felt need, by providing in one embodiment, a helper virus based on the Ad2 serotype for use in the Cre/loxP system for the generation of Ad vectors deleted of all Ad protein coding sequences. Using this and helper virus based on Ad5... | 05/04/2004 |
| 6730514 | Stable human oral cancer cell carcinoma cell line The present invention is directed to a stable, continuous, human oral squamous cell carcinoma cell line from the floor of the mouth of a habitual tobacco consumer using a variety of growth supplements and complement mediated lysis to obtain a fibroblast free culture... | 05/04/2004 |
| 6727230 | Immune stimulation by phosphorothioate oligonucleotide analogs Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by s... | 04/27/2004 |
| 6720153 | Luciferase reporter bioassay of parathyroid hormone compounds This invention is directed to a bioassay for determining the functionality of parathyroid hormone compounds. More particularly, this invention is directed to a bioassay wherein the compound to be tested is added to a culture of parathyroid hormone receptor expressin... | 04/13/2004 |
| 6716975 | Antisense modulation of EDG1 expression Antisense compounds, compositions and methods are provided for modulating the expression of EDG1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding EDG1. Methods of using these compounds for mo... | 04/06/2004 |
| 6716425 | Method of preventing cancer recurrence Methods for treating cancer in a mammalian patient having cancer and a functional immune system, and for preventing recurrences of cancer following completion of cancer therapy, are described. The methods involve administration of a course of therapy with modified T... | 04/06/2004 |
| 6713302 | Growth differentiation factor-6 Growth differentiation factor-6 (GDF-6) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-6 polypeptide and polynucleotide sequences. ... | 03/30/2004 |
| 6713247 | Human CNS cell lines and methods of use therefor Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to pre... | 03/30/2004 |
| 6709864 | Adipogenic differentiation of human mesenchymal stem cells A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogen... | 03/23/2004 |
| 6703017 | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures The subject invention concerns new methods which make it possible, for the first time, to grow functional islet-producing stem cells (IPSCs), islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in in vitro cultures. The subject invention also conc... | 03/09/2004 |
| 6703016 | Apoptotic bodies, monocyte derived cells containing the same, a process for their preparation and their uses as vaccines The present invention relates to apoptotic bodies derived from human tumor cells or cell lines recovered from patient's tumor biopsy and induced to apoptotis, said apoptotic bodies having the following characteristics: they maintain plasma membrane integr... | 03/09/2004 |
| 6703485 | Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a B... | 03/09/2004 |
| 6692957 | Method for separating cells The present invention is directed to a method of separating cells of interest which method comprises: determining cells of interest; selecting a promoter specific for the cells of interest; introducing a nucleic acid molecule encoding green fluorescent pr... | 02/17/2004 |
| 6692750 | Alphavirus expression vector The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having translation enhancing activity. Such vectors can be used to ... | 02/17/2004 |
| 6686197 | Method for producing preparations of mature and immature pancreatic endocrine cells, the cell preparation and its use for treatment of diabetes mellitus A method for preparing a preparation of mammalian pancreatic endocrine cells comprising the steps: dissociating intact pancreatic tissue into a cell suspension comprising single cells and cell aggregates; enriching said cell suspension with regard to the ... | 02/03/2004 |
| 6686200 | Methods and compositions for the large scale production of recombinant adeno-associated virus This invention provides novel methods and compositions for use in the efficient and large-scale production of recombinant adeno-associated virus (AAV). Described herein are new producer cell lines, recombinant adenovirus or herpes virus vectors and AAV co... | 02/03/2004 |
| 6682730 | Transplants for myocardial scars A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar... | 01/27/2004 |
| 6682929 | Adenovector complementing cells The invention provides cells, particularly NCI-H460 cells and Calu-1 cells, for the propagation of replication-deficient adenoviral vectors. The cells are lung carcinomas with either a wild-type p53 gene or a heterozygous K-ras mutation. The cells compris... | 01/27/2004 |
| 6680191 | Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are d... | 01/20/2004 |
| 6677156 | Non-adenoviral gene product-based complementing cells for adenoviral vectors The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene... | 01/13/2004 |
| 6673606 | Therapeutic uses for mesenchymal stromal cells Human mesenchymal stromal cells can be induced to differentiate into oligodendrocytes and neurons, respectively. For these cell types, therefore, MSCs can be a therapeutic source, either in vitro or in vivo, in the context of treating pathologies of the c... | 01/06/2004 |
| 6673611 | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of... | 01/06/2004 |
| 6673603 | Cell paste comprising keratinocytes and fibroblasts The present invention provides the use and composition of matter of angiogenic or other growth factors expressed by combining various types and stages of differentiation of allogeneic human cell strains or lines in unencapsulated pastes (mixed with or app... | 01/06/2004 |
| 6673768 | Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating) Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the inv... | 01/06/2004 |
| 6670139 | Cell-free assay using oncogene-induced apoptosis to identify inhibitors of apoptosis in drug-resistant cells The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound which selectively activates apoptosis in transformed cells. ... | 12/30/2003 |
| 6670188 | Packaging systems for human recombinant adenovirus to be used in gene therapy The invention provides improved methods and products based on adenoviral materials which can advantageously be used in for instance gene therapy. In one aspect an adenoviral vector is provided which has no overlap with a suitable packaging cell line which... | 12/30/2003 |
| 6670180 | Cell culture media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.... | 12/30/2003 |
| 6670178 | In Vivo production and delivery of insulinotropin for gene therapy The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes erythropoietin or an insulinotropin (e.g., derivatives of ... | 12/30/2003 |
| 6667176 | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells This disclosure provides a system for obtaining expression libraries from primate pluripotent stem (pPS) cells. pPS cells can be maintained in vitro without requiring a layer of feeder cells to inhibit differentiation. The role of the feeder cells is repl... | 12/23/2003 |
| 6660471 | Enhanced replication of HCV RNA This invention provides methods of generating cells that stably replicate sub-genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and that stably replicate HCV sub-genomic replicons. The invent... | 12/09/2003 |
| 6656730 | Oligonucleotides conjugated to protein-binding drugs Ligand-conjugated oligomeric compounds are described wherein ligands are conjugated to one or more sites on an oligomeric compound including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The ligand can be attached via an optional linkin... | 12/02/2003 |
| 6653098 | Method of producing mouse and human endostatin Methods for producing mouse and human endostatin are disclosed. Methods for refolding and purifying endostatin from inclusion bodies expressed in bacteria and nucleic acids encoding full-length and truncated forms of endostatin are also disclosed.... | 11/25/2003 |
| 6653134 | Isolated stromal cells for use in the treatment of diseases of the central nervous system Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and admini... | 11/25/2003 |
| 6649072 | Method for producing autologous platelet-rich plasma A novel method for producing an autologous platelet rich blood composition is described. The resulting blood composition is useful in procedures for enhancing bone fusion, hemostasis, and repairing soft tissue in animals.... | 11/18/2003 |
| 6649367 | Human cancer cell line malignantly altered by expression of angiogenic factor A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low angiogenesis-inducing ability, and selecting a cell that over... | 11/18/2003 |
| 6645943 | Method of down-regulating gene expression Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmacological formulation comprising a chimeric oligonucleotide complementary to the gene is orally administered to an animal. The oligonucleotide administered has... | 11/11/2003 |
| 6645727 | Antibody compositions for preparing enriched mesenchymal progenitor preparations The present invention relates to antibody composition that are useful in preparing enriched mesenchymal progenitor cell preparations. The invention also relates to kits for carrying out the processes and to the cell preparations prepared by the processes.... | 11/11/2003 |
