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| Number | Title | Issue Date |
| 7312319 | Neurotrophic factor (NT-4) immunoassay systems A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucl... | 12/25/2007 |
| 7265201 | Human chemotactic cytokine The present invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to proteins or polypeptides referred to herein as isolated and/or recombinant human eotaxin, including synthetic polype... | 09/04/2007 |
| 7250404 | Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and e... | 07/31/2007 |
| 7244616 | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced express... | 07/17/2007 |
| 7241740 | Peptides as solubilizing excipients for transforming growth factor beta proteins The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubi... | 07/10/2007 |
| 7208292 | Nucleic acid encoding an interleukin-9 receptor variant This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is delete... | 04/24/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7166702 | Cytotoxic conjugates comprising a chemokine receptor targeting agent Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune... | 01/23/2007 |
| 7157418 | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immu... | 01/02/2007 |
| 7132508 | Mammalian chemokine reagents A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also prov... | 11/07/2006 |
| 7056698 | Nucleic acids encoding interleukin-9 receptor variants This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is delete... | 06/06/2006 |
| 7049396 | Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes Methods of inhibiting leukocyte O2− production and attracting leuckocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These p... | 05/23/2006 |
| 7041813 | Canine herpes virus alpha transinducing factor nucleic acid molecules The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genome... | 05/09/2006 |
| 7008781 | Method of enhancing the biological activity of ligands Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are described. Nucleic acids encoding these novel fusion polypeptide ligands enabl... | 03/07/2006 |
| 6969609 | Recombinant vector expressing multiple costimulatory molecules and uses thereof The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect... | 11/29/2005 |
| 6852515 | Stimulation of angiogenesis via enhanced endothelial expression of syndecan-4 core The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having ... | 02/08/2005 |
| 6777205 | Host cells expressing recombinant human erythropoietin The gene coding for human erythropoietin (EPO) was obtained from human genomic DNA. Thc gene used does not include sequences from regions at i 5′ of the first translated ATG and ii 3′ of the stop codon of the EPO gene. The gene was cloned into an expression plas... | 08/17/2004 |
| 6689365 | Single-chain fertility hormones with fsh and LH activity Glycosylated or nonglycosylated proteins of the formula FSHଲ-(linker1)n1 -LHଲ(1-X)-(linker2)n2 - wherein FSHଲ is a vertebrate follicle stimulating hormone ଲ subuni... | 02/10/2004 |
| 6652848 | Dendritic cell hybrids Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic cell hybrids.... | 11/25/2003 |
| 6566097 | Feline cytokine protein A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinan... | 05/20/2003 |
| 6451759 | Noncleavable Fas ligand This invention generally provides polypeptides comprising a noncleavable form of a Fas ligand and having a capacity to activate a Fas receptor-mediated pathway involved in cell death, pharmaceutical compositions of such polypeptides, nucleic acids encodin... | 09/17/2002 |
| 6451305 | Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand Methods for stimulating a T cell response to a tumor cell in a subject with a tumor which involve modifying the tumor cell to express a CD2 ligand and a CD28 or CTLA4 ligand, are disclosed. Methods wherein the tumor cell is obtained from the subject and m... | 09/17/2002 |
| 6365356 | Receptors that regulate cell signaling relating to chemokines A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group consisting of a CXC receptor, a CC receptor and a CXXXC receptor... | 04/02/2002 |
| 6348192 | Interleukin-2 mutein expressed from mammalian cells Glycosylated interleukin-2 muteins are described. A method of producing the muteins using mammalian cells is included. The muteins may be incorporated into pharmaceutical preparations useful for, e.g., cancer therapy.... | 02/19/2002 |
| 6284485 | Nucleic acids encoding osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6238914 | Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a non-mammalian virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is ex... | 05/29/2001 |
| 6238889 | Molecular cloning and expression of the Pro8 isoform of human IL-3 The invention relates to nucleotide sequences encoding human interleukin-3 (hIL-3) as well as recombinant DNAs, expression cassettes, transformed host cells, and recombinant expression methods comprising such sequences. Additionally, the invention describ... | 05/29/2001 |
| 6187550 | Methods and cell lines for screening compositions and genes for ability to interact with IL-1ଲ and ice processing Embodiments of the present invention are directed to non-naturally occurring cells and methods for screening compositions and genes which interact with interleukin 1 beta and interleukin-1 beta converting enzyme (ICE) processing, methods and non-naturally... | 02/13/2001 |
| 6117991 | Biologically active synthetic thyrotropin and cloned gene producing same Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.... | 09/12/2000 |
| 6103501 | Single chain glycoprotein hormones comprising two ଲ and one subunits and recombinant production thereof Single-chain agonists and/or antagonists of the glycoprotein hormones are disclosed. These proteins are of the formula 댡 -(linker1)m --(linker2)n -댢 ... | 08/15/2000 |
| 6060270 | Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on culturing adult kidney cells in a culture media treated with comb... | 05/09/2000 |
| 6001649 | Chemokine NC28 (monocyte chemotactic protein-3, MCP-3) polypeptides and their recombinant production A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal amino acids also exhibit chemotactic activity. The polypeptides may be used as anticancer agents or immunomodul... | 12/14/1999 |
| 5985613 | Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "to inhibit the replication of viruses, in particular of retroviruses An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is encoded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; or ii) is encoded by DNA sequences which are degenerate to those... | 11/16/1999 |
| 5981214 | Production of proteins using homologous recombination Methods and compositions are provided for expression of mammalian genes in culture. An amplifiable gene is introduced by homologous recombination in juxtaposition to a target gene, the resulting combination of amplifiable gene and target gene transferred ... | 11/09/1999 |
| 5976522 | Lymphocyte chemoattractant factor and uses thereof Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.... | 11/02/1999 |
| 5958737 | Single-chain ଲ subunit dimers of the glycoprotein hormones and recombinant materials related thereto Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. In one embodiment of these single-chain forms, the and ଲ subunits of the wild-type heterodimers or their var... | 09/28/1999 |
| 5916770 | Macrophage stimulating protein variant and method for producing the same The present invention relates to a macrophage stimulating protein wherein a cysteine residue at position 672 from the N-terminus in the amino acid sequence of native form macrophage stimulating protein is deleted or substituted by another amino acid resid... | 06/29/1999 |
| 5874250 | DNA encoding for a protein containing the extracellular domain of lymphocyte activation gene 3 The present invention relates to a protein containing the extracellular domain of LAG-3, and DNA sequences coding for the protein and the pharmaceutical and biological uses of the protein.... | 02/23/1999 |
| 5858721 | Three-dimensional cell and tissue culture system The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue ar... | 01/12/1999 |
| 5834245 | PRLTS proteins and DNA's encoding the same A gene is provided which is present in the deletion region of a chromosome common in lung cancer, hepatocellular carcinoma and colorectal cancer and encodes a novel protein, a protein encoded by the gene (PRLTS protein), and a method of discriminating tum... | 11/10/1998 |
