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| Number | Title | Issue Date |
| 7906329 | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fra... | 03/15/2011 |
| 7833787 | Method for recloning Chinese hamster ovary (CHO) cells A new method for selecting clones and recloning mammalian cells which are of importance for the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention relates to methods of depositi... | 11/16/2010 |
| 7776590 | Stable cell lines expressing hERG A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided. ... | 08/17/2010 |
| 7771997 | Enhanced expression and stability regions Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a... | 08/10/2010 |
| 7645609 | Method for controlling sialylation of proteins produced by mammalian cells The invention provides media and methods for culturing mammalian cells whereby the sialylation of a protein produced by the cells is increased. The medium can contain N-acetylmannosamine and, optionally, galactose. The medium may also comprise fructose and mannose. ... | 01/12/2010 |
| 7432246 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 10/07/2008 |
| 7425446 | Antibody composition-producing cell The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 09/16/2008 |
| 7423135 | β-actin and rpS21 promoters and uses thereof The invention relates to isolation of novel β-actin and ribosomal protein S21 (rpS21) promoters and uses thereof. In particular, this invention features nucleotide sequences for rodent β-actin promoters including, hamster, rat, and mouse, and hamster rpS21 promote... | 09/09/2008 |
| 7419799 | Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... | 09/02/2008 |
| 7399612 | VEGF-binding fusion proteins and nucleic acids encoding the same Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for loca... | 07/15/2008 |
| 7396664 | VEGF-binding fusion proteins and nucleic acids encoding the same Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local admin... | 07/08/2008 |
| 7390660 | Methods for growing mammalian cells in vitro The invention relates to a method for reducing glucose consumption during cultivation of animal cells, which comprises cultivating animal cells in the presence of a bi- or tricarbonic acid or a salt thereof at a concentration of about 1 to 50 mmol/l. ... | 06/24/2008 |
| 7384744 | Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products An expression vector for eukaryotic cells comprising a gene which codes for a protein of interest, functionally linked to a hamster-ubiquitin/S27a-promoter and a gene which codes for a fluorescent protein. Preferably the expression vector also contains an amp... | 06/10/2008 |
| 7381560 | Expression and use of anti-CD20 antibodies Disclosed are immunologically active antibodies directed against the CD20 antigen, as well as host cells comprising nucleic acid sequences encoding the light chains and heavy chains of immunologically active antibodies wherein the cell is capable of expressing and s... | 06/03/2008 |
| 7368285 | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo... | 05/06/2008 |
| 7364878 | Method for simultaneous production of multiple proteins; vectors and cells for use therein The invention relates to the field of biochemistry, molecular biology, pharmacology and diagnosis. More specifically the present invention relates to the production of proteins in a host cell. Even more specifically, the invention relates to a method for improving e... | 04/29/2008 |
| 7335491 | Production of anti-abeta An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 02/26/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7323332 | Preparation method of insect cell extract solution for cell-free protein synthesis, the insect cell extract solution and cell-free synthesis method of protein using the insect cell extract solution The present invention provides a preparation method of an insect cell extract solution for cell-free protein synthesis, the insect cell extract solution, a protein synthesis method in a cell-free system, which uses the insect cell extract solution, and a kit for cel... | 01/29/2008 |
| 7300773 | Production of TNFR-Ig An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/27/2007 |
| 7294484 | Production of polypeptides An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative as... | 11/13/2007 |
| 7273727 | Fusion proteins for prodrug activation The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is ... | 09/25/2007 |
| 7267965 | Means and methods for regulating gene expression The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the pr... | 09/11/2007 |
| 7264950 | Reaction system for performing in the amplification of nucleic acids A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said ... | 09/04/2007 |
| 7262039 | Polypeptide This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transfo... | 08/28/2007 |
| 7262025 | Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5′ upstream from a myeloproliferative sarcoma virus (MPSV) promoter. ... | 08/28/2007 |
| RE39792 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 08/21/2007 |
| 7238776 | TNF binding proteins The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein... | 07/03/2007 |
| 7232668 | Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities Fc fusion proteins of human G-CSF with increased biological activities relative to rhG-CSF on a molar basis are disclosed. The hG-CSF-L-vFc fusion protein comprises hG-CSF, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The F... | 06/19/2007 |
| 7226759 | Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities Fc fusion proteins of human G-CSF with increased biological activities relative to rhG-CSF on a molar basis are disclosed. The hG-CSF-L-vFc fusion protein comprises hG-CSF, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The F... | 06/05/2007 |
| 7220556 | Preparation of factor XIIIa by gene manipulation The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene mani... | 05/22/2007 |
| 7211406 | Potassium channel A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected with the expression vector, an antibody binding to the polypeptid... | 05/01/2007 |
| 7208316 | Polynucleotide overexpressed in tumors The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/24/2007 |
| 7208273 | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when admin... | 04/24/2007 |
| 7208312 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/24/2007 |
| 7195915 | Vectors for animal cells and use thereof Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated ... | 03/27/2007 |
| 7192741 | DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory s... | 03/20/2007 |
| 7189535 | Modulators of the function of receptors of the TNF/NGF receptor family and other proteins Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided. ... | 03/13/2007 |
