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| Number | Title | Issue Date |
| 7416848 | DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r... | 08/26/2008 |
| 7413900 | Immortalized fibroblasts Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early stage mouse embryo is provided. Methods of preparing an immortalized... | 08/19/2008 |
| 7399634 | Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same The object of the present invention is to provide a method for preparing a basement membrane comprising extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells. This basement... | 07/15/2008 |
| 7393655 | Methods of identifying melanin concentrating hormone receptor antagonists This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc... | 07/01/2008 |
| 7282352 | Homogeneity and secretion of recombinant proteins in mammalian systems The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human ... | 10/16/2007 |
| 7232899 | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the developm... | 06/19/2007 |
| 7223599 | Immortalization of human post-mitotic cells The present invention provides an immortalized human cardiomyocyte cell line. The present invention further provides a method for preparing a human immortalized cell line derived from a post-mitotic primary cell culture. ... | 05/29/2007 |
| 7214368 | Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encodin... | 05/08/2007 |
| 7211406 | Potassium channel A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected with the expression vector, an antibody binding to the polypeptid... | 05/01/2007 |
| 7189567 | Method of culturing human chondrocytes This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human chondrocytes together with perichondral cells in the chondrogenic stage, as fee... | 03/13/2007 |
| 7063958 | Nucleic acids db, the receptor for leptin The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and char... | 06/20/2006 |
| 7052692 | Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularl... | 05/30/2006 |
| 7033595 | Pseudotyped retroviruses and stable cell lines for their production Cells that produce inventive pseudotyped retroviruses having a broad host range have been produced. In one aspect of the invention, the cells produce retroviruses pseudotyped with at least two different viral glycoproteins, such as togaviral glycoproteins. In altern... | 04/25/2006 |
| 7029857 | Processes for obtaining compounds employing SNORF72 receptors This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, cells comprising such vectors, antibo... | 04/18/2006 |
| 7029914 | DNA encoding SNORF36 receptors This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 r... | 04/18/2006 |
| 6943245 | Tumor suppressor CAR-1 The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the correspo... | 09/13/2005 |
| 6846674 | Genetically modified fibroblast cells The invention relates to genetically modified fibroblast cells which comprise the following properties: (a) a gene, encoding a subunit of the transcription factor AP-1, of its genome is inactivated and/or a component, acting on the AP-1 transcription factor of the s... | 01/25/2005 |
| 6794187 | Mass1 gene, a target for anticonvulsant drug development The present invention relates to a novel gene which is associated with audiogenic seizures in mice. The gene is known as the Monogenic Audiogenic Seizure-susceptible gene or mass1. The product of the mass1 gene is designated MASS1. Nucleic acid molecules that encode... | 09/21/2004 |
| 6790606 | Extracellular matrix signaling molecules Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compos... | 09/14/2004 |
| 6770444 | Methods of identifying or screening for agents that binds the Ob-Re This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for dete... | 08/03/2004 |
| 6734005 | Matrix metalloproteinases The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using al... | 05/11/2004 |
| 6723552 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc... | 04/20/2004 |
| 6713268 | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation Methods to identify agents having ocular hypotensive activity which have reduced or absent ability to stimulate iridial hyperpigmentation are disclosed. The methods reside in part in detecting the ability of a test compound to interact with the FP receptor. ... | 03/30/2004 |
| 6670151 | Porcine stem cell factor varients and recombinant cells expressing such polypeptides This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production and isolation of such polynucleotides and polypeptides. More particularly... | 12/30/2003 |
| 6670139 | Cell-free assay using oncogene-induced apoptosis to identify inhibitors of apoptosis in drug-resistant cells The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound which selectively activates apoptosis in transformed cells. ... | 12/30/2003 |
| 6670178 | In Vivo production and delivery of insulinotropin for gene therapy The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes erythropoietin or an insulinotropin (e.g., derivatives of ... | 12/30/2003 |
| 6623980 | Exo1 and Exo2, exocytotic proteins The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are... | 09/23/2003 |
| 6548269 | Ob receptor and methods for the diagnosis and treatment of body weight disorders, including obesity and cachexia The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cel... | 04/15/2003 |
| 6518021 | Method for extracting quantitative information relating to an influence on a cellular response Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Flourescent Protein (GFP, EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent prot... | 02/11/2003 |
| 6500449 | Intraocular transplantation of encapsulated cells Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. Th... | 12/31/2002 |
| 6475790 | Assay for screening agents that alter angiogenesis A multicellular in vitro assay which models the combined stages of angiogenesis is disclosed. The assay permits the evaluation of drug candidates for their potential utility in treating pathological conditions such as chronic dermal ulcers, tumors, diabet... | 11/05/2002 |
| 6468756 | Methods of identifying compounds that bind to SNORF25 receptors This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalia... | 10/22/2002 |
| 6455290 | Tankyrase homolog protein (THP), nucleic acids, and methods related to the same The present invention provides a human polypeptide homolog of human tankyrase protein (THP) and polynucleotides which identify and encode THP. In addition, the invention provides expression vectors, host cells and methods for its production. The invention... | 09/24/2002 |
| 6432702 | Mammalian growth factor nucleic acids, vectors, and host cells A truncated mammalian growth factor, displaying homology to both basic and acidic fibroblast growth factor in a single polypeptide, is disclosed herein. The growth factor is substantially smaller (i.e. has fewer amino acid residues) than the full-length m... | 08/13/2002 |
| 6416754 | Anaerobe targeted enzyme-mediated prodrug therapy A genetically-engineered anaerobic organism is provided which, under anaerobic conditions present in a solid tumor, produces an enzyme capable of catalyzing the conversion of a prodrug to its highly cytotoxic product in situ and methods of treating tumors... | 07/09/2002 |
| 6372896 | Kits for detecting fOHY030 The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung, and bone tumors, various types of skin cancers... | 04/16/2002 |
| 6372502 | Retroviral packaging cell lines and processes of using same This invention provides a mammalian cell useful for retroviral packaging comprising two plasmids, both of which comprise the 5' long terminal repeat (LTR) sequence from a helper virus, neither of which comprise a functional .psi. packaging sequence or a 3... | 04/16/2002 |
| 6348344 | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active hepar... | 02/19/2002 |
| 6329199 | Retroviral vectors produced by producer cell lines resistant to lysis by human serum Retroviral vectors which are resistant to inactivation by human serum. The retroviral vectors are produced in a cell line which is resistant to lysis by human serum, such cell lines including the HOS, Mv-1-Lu, HT1080, TE671, and human 293 cell lines, as w... | 12/11/2001 |
| 6329197 | DNA encoding galanin GALR3 receptors and uses thereof This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directe... | 12/11/2001 |
