"During my service in the United States Congress, I took the initiative in creating the Internet."
Al Gore ; The basis for the later misquote by US Republicans that Gore had "invented" the Internet. Gore was the leading political champion of the modern-day Internet.
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| Number | Title | Issue Date |
| RE40555 | Preparation of agarose coated, solid agarose beads containing secretory cells Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and sec... | 10/28/2008 |
| 7416848 | DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r... | 08/26/2008 |
| 7029914 | DNA encoding SNORF36 receptors This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 r... | 04/18/2006 |
| 7029905 | Method for the cellular high-throughput-detection of receptor ligand interactions The invention relates to cells which comprise a membrane receptor which comprises a ligand-binding section, a membrane-localization signal and a mediator section, and which is characterized in that only when there is binding or, alternatively, only when there is a l... | 04/18/2006 |
| 7029857 | Processes for obtaining compounds employing SNORF72 receptors This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, cells comprising such vectors, antibo... | 04/18/2006 |
| 6858409 | Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors Compounds are disclosed having the general formula R1—X—R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 ... | 02/22/2005 |
| 6770444 | Methods of identifying or screening for agents that binds the Ob-Re This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for dete... | 08/03/2004 |
| 6709837 | Polypeptide and production thereof Disclosed are (1) a polypeptide (I) including the following amino acid sequence (II) in a molecule thereof: TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys (II) | 03/23/2004 |
| 6653097 | Human calcium channel compositions and methods Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and meth... | 11/25/2003 |
| 6635442 | Intron/exon structure of the human and mouse 댣-adrenergic receptor genes The present invention relates to the intron and exon structure of the gene encoding 댣 adrenergic receptor polypeptides of mouse and human origin, which polypeptides are useful in a procedure for studying the effects of various chemical agents on th... | 10/21/2003 |
| 6599873 | Interleukin-1 inhibitors, compositions, and methods of treatment Interleukin-1 inhibitors are provided. Compositions comprising an interleukin-1 inhibitor are provided. Methods of treating a patient comprising administering an interleukin-1 inhibitor are provided.... | 07/29/2003 |
| 6468756 | Methods of identifying compounds that bind to SNORF25 receptors This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalia... | 10/22/2002 |
| 6432655 | Method of obtaining compositions This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B recepto... | 08/13/2002 |
| 6387696 | Human calcium channel compositions and methods Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and meth... | 05/14/2002 |
| 6376243 | DNA encoding a human serotonin receptor (5-HT4B) and uses thereof This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B recepto... | 04/23/2002 |
| 6348344 | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active hepar... | 02/19/2002 |
| 6329197 | DNA encoding galanin GALR3 receptors and uses thereof This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directe... | 12/11/2001 |
| 6300087 | DNA encoding a human serotonin receptor (5-HT4B) and uses thereof This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is mammalian 5-HT4B receptor,... | 10/09/2001 |
| 6294347 | Human FCγ receptor III Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic prupura. Cells ex... | 09/25/2001 |
| 6268216 | Reagents and methods for the screening of compounds useful in the treatment of neurological diseases This invention relates to the gene sequence of a novel transcription factor specific for central 5-HT (serotonergic) neurons. The sequence and products are useful in screening methods for identifying and testing agonists and antagonists of seronergic acti... | 07/31/2001 |
| 6221616 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 re... | 04/24/2001 |
| 6221613 | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 re... | 04/24/2001 |
| 6210967 | DNA encoding a mammalian LPA receptor and uses thereof This invention provides an isolated nucleic acid encoding a mammalian LPA receptor, a purified mammalian LPA receptor, vectors comprising isolated nucleic acid encoding an mammalian LPA receptor, cells comprising such vectors, antibodies directed to a mam... | 04/03/2001 |
| 6096514 | Human calcium channel compositions and methods Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and meth... | 08/01/2000 |
| 6090623 | Recombinant human calcium channel ଲ4 subunits Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the... | 07/18/2000 |
| 6083749 | DNA encoding a human serotonin receptor (5-HT4B) and uses thereof This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B recepto... | 07/04/2000 |
| 6010872 | Recombinant production of TGF-ଲ type III receptor (betaglycan) polypeptides The invention provides cDNAs encoding the human and rodent transforming growth factor-beta (TGF-ଲ) type III receptors. Nucleic acids encoding the mammalian receptors and soluble receptor polypeptides derived from them, expression systems for their p... | 01/04/2000 |
| 6008011 | TGF-ଲ type II receptor cDNAs The mammalian TGF-ଲ type II receptor has been cloned. Nucleic acids encoding full-length and soluble receptor polypeptides, as well as fragments of such nucleic acids useful as probes, are provided. Corresponding vectors, transformed host cells, and... | 12/28/1999 |
| 5985585 | Processes using a human serotonin receptor (5-HT4B) The invention provides for processes for identifying chemical compounds which specifically bind to a human 5-HT4B having the amino acid sequence of SEQ ID NO: 2.... | 11/16/1999 |
| 5968749 | Acyl coenzyme A : cholesterol acyltransferase (ACAT) This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A: cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated wi... | 10/19/1999 |
| 5851824 | Human calcium channel -1C/-1D, -2, ଲ-1, and γsubunits and cells expressing the DNA Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and meth... | 12/22/1998 |
| 5846949 | Method for eliciting an immune response using a gene expression system that co-delivers an RNA polymerase with DNA The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the... | 12/08/1998 |
| 5807742 | Neurokinin receptor cell lines A method for producing high level expression of neuropeptide receptors and stable cell lines useful therein. This method involves culturing a cell line containing amplified copies of a cDNA sequence encoding a neuropeptide receptor containing an expressio... | 09/15/1998 |
| 5807557 | Soluble herpesvirus glycoprotein complex The invention features a preparation of a soluble herpesvirus gH/gL complex, a cell encoding a soluble herpesvirus gH/gL complex, a vaccine comprising the complex and a method of immunizing a human against a herpesvirus infection using the complex. The in... | 09/15/1998 |
| 5792846 | Human calcium channel compositions and methods Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and meth... | 08/11/1998 |
| 5783402 | Method of identifying ligands and anatgonists of G-protein coupled receptor The present invention relates, in general, to a method of identifying ligands and antagonists of ligands. In particular, the present invention relates to a method of identifying ligands and antagonists of ligands which bind to cloned G8 - or G | 07/21/1998 |
| 5776746 | Gene amplification methods The present invention provides improved methods for the amplification and expression of recombinant genes in cells. The methods of the present invention permit the isolation of cell lines which have co-amplified input recombinant sequences which encode an... | 07/07/1998 |
| 5731412 | Protein, DNA coding for same and method of producing the protein A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the... | 03/24/1998 |
| 5719042 | Nucleic acids encoding transcription factor APRF (acute phase response factor) Mammal transcription factor APRF, process for the preparation of it, DNAs encoding the product, replication and expression vector comprising the DNA, host cells transformed or tranfected with the replication and expression vector, evaluating and screening... | 02/17/1998 |
| 5714381 | DNA encoding human alpha 1 adrenergic receptors and uses thereof This invention provides an isolated nucleic acid molecule encoding a human adrenergic receptor.... | 02/03/1998 |