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| Number | Title | Issue Date |
| 7670837 | Non-tumorigenic MDCK cell line for propagating viruses The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically,... | 03/02/2010 |
| 7368536 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/06/2008 |
| 7279329 | Expression system for producing collagen A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems and methods for the expression of the DNA molecule are also provided... | 10/09/2007 |
| 7226779 | Hybrid adenoviral vector An adenoviral vector is disclosed that includes two adenoviral ITRs, wherein the two adenoviral ITRs flank a packaging signal and a single retroviral LTR operably linked to a nucleic acid sequence of interest, wherein the adenoviral vector does not include a nucleic... | 06/05/2007 |
| 7223596 | Malignant endothelial cell line and uses thereof in models for angiogenesis An immortalized hemangiosarcoma cell line of malignant canine endothelial cells which possesses surface expression characteristics and growth factor and cytokine expression profiles typical of nonmalignant activated endothelial cells is provided. In vitro and in viv... | 05/29/2007 |
| 7169589 | Silicatein-mediated synthesis of amorphous silicates and siloxanes and use thereof Silicatein is an enzyme of silicate-forming organisms used for the synthesis of their silicate scaffold. The present invention relates to the use of highly-expressed and highly active recombinant silicatein, silicatein isolated from natural sources after gene induct... | 01/30/2007 |
| 7070944 | System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a system comprising genetic material encoding a fatty acid transport medi... | 07/04/2006 |
| 7045318 | Recombinant fusion proteins to growth hormone and serum albumin The invention describes methods of producing fusion proteins of albumin and growth hormone and products obtained by the methods. ... | 05/16/2006 |
| 7041473 | Alzheimer's disease secretase, APP substrates therefor, and uses thereof The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protei... | 05/09/2006 |
| 7038108 | Polynucleotide encoding lysyl-tRNA synthetase from This invention relates to isolated nucleic acid fragments encoding aminoacyl-tRNA synthetases and particulary lsoleucyl-, lysyl-, phenylalanyl- and prolyl-tRNA synthetases from Zea mays, Oryza sativa, Glycine max and Tritium aestivum. The invention also relat... | 05/02/2006 |
| 7033595 | Pseudotyped retroviruses and stable cell lines for their production Cells that produce inventive pseudotyped retroviruses having a broad host range have been produced. In one aspect of the invention, the cells produce retroviruses pseudotyped with at least two different viral glycoproteins, such as togaviral glycoproteins. In altern... | 04/25/2006 |
| 7015035 | RD114-based retroviral packaging cell line and related compositions and methods This invention provides a retroviral packaging cell comprising a suitable mammalian cell having therein (i) a first recombinant nucleic acid comprising MMLV gag and pol genes and a selectable marker, and (ii) a second recombinant nucleic acid comprising RD114 envelo... | 03/21/2006 |
| 6996604 | Pre-availability of a lecture to promote interactivity A method, computer program, and data processing system for promoting an interactive discussion of lecture notes prior to an actual lecture using those notes is disclosed. An first client uploads lecture notes for perusal by students. If a student has a question rega... | 02/07/2006 |
| 6913918 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 07/05/2005 |
| 6897052 | N-acetylglycosaminyl transferase genes N-acetylglycosaminyltransferase V nucleic acids, proteins encoded by the nucleic acids, and uses of the nucleic acids and proteins. ... | 05/24/2005 |
| 6897045 | Adeno-associated virus vectors The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste... | 05/24/2005 |
| 6849437 | 47153, a human glycosyltransferase family member and uses therefor The invention provides isolated nucleic acids molecules, designated 47153 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47153 nuc... | 02/01/2005 |
| 6825036 | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell A novel MDCK-derived cell line (B-702) is provided that can be grown in the absence of fetal calf serum and in suspension culture for allowing a tank culture on the production scale and needs no carrier in suspension culture, as well as a process for producing virus... | 11/30/2004 |
| 6716625 | Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use The present invention relates to fungal histidine kinases. In particular, the present invention is directed to histidine kinases from Neurospora (e.g., N. crassa), Candida (e.g, C. albicans), and Aspergillus (e.g., A. fumigatus), and related com... | 04/06/2004 |
| 6703223 | Nucleotide sequences coding for the MtrA and/or MtrB proteins The present invention provides nucleotide sequences from Coryneform bacteria which code for the MtrA and/or MtrB proteins and processes for the fermentative preparation of amino acids using bacteria in which the mtrA and/or mtrB genes are attenuated.... | 03/09/2004 |
| 6656720 | Animal cells and processes for the replication of influenza viruses Animal cells are described which can be infected by influenza viruses and which are adapted to growth in suspension in serum-free medium. Processes for the replication of influenza viruses in cell culture using these cells are furthermore described, as we... | 12/02/2003 |
| 6645736 | Calcium independent cytosolic phospholipase A2/B enzymes The invention provides a novel calcium-independent cytosolic phospholipase A2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.... | 11/11/2003 |
| 6645509 | Polypeptide expressed in the horny layer of epidermis and use thereof The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is involved in horny layer cell cohesion. The invention also... | 11/11/2003 |
| 6641526 | Development of normal offspring from oocytes injected with freeze-dried spermatozoa The invention provides a method for freeze-drying spermatozoa to obtain at least one reconstituted spermatozoon whose head (nucleus) is capable of fertilizing an oocyte to produce a live offspring. The motility of spermatozoa which have been freeze-dried ... | 11/04/2003 |
| 6593138 | Cryopreserving somatic cells with an arabinogalactan containing cryopreservation medium Methods and compositions for cryopreserving somatic cells are provided. In one embodiment, a cell cryopreservation medium is provided which includes an effective amount of arabinogalactan to maintain the viability of cells upon freezing, storage and thawi... | 07/15/2003 |
| 6569642 | Receptor that binds trail A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provid... | 05/27/2003 |
| 6555325 | System for detection of a functional interaction between a compound and a cellular signal transduction component The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion ch... | 04/29/2003 |
| 6541197 | Vehicles for stable transfer of green fluorescent protein gene and methods of use for same The present invention describes an efficient retroviral or viral based method that allows easy and quick identification of gene transfer in living, transduced mammalian cells. Retroviral and viral vector producer cells were generated containing a gene for... | 04/01/2003 |
| 6527689 | Maternally transcribed protein The invention provides a human maternally transcribed protein (HMTP) and polynucleotides which identify and encode HMTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods ... | 03/04/2003 |
| 6525186 | Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful of serologic diagnosis of canine leishmaniosis and protein obtained A chimeric polypeptide encoded by a chimeric gene formed by DNA sequences that encode four antigenic determinants of L. infantum is disclosed. These antigenic determinants are obtained from rLiP2a, rLiP2b, rLiH2A and rLiPO. The protein obtained, has a mol... | 02/25/2003 |
| 6500653 | Nucleic acids and polypeptides which resemble RHO and which interact with cell signaling pathways and proteins The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction... | 12/31/2002 |
| 6475775 | PARG, a GTPase activating protein which interacts with PTPL1 The invention describes nucleic acids encoding the PARG protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods... | 11/05/2002 |
| 6455298 | Animal cells and processes for the replication of influenza viruses Animal cells are described which can be infected by influenza viruses and which are adapted to growth in suspension in serum-free medium. Processes for the replication of influenza viruses in cell culture using these cells are furthermore described, as we... | 09/24/2002 |
| 6451549 | Secreted renilla luciferase A polynucleotide encoding a secreted form of wild type Renilla luciferase. Also provided is a polynucleotide encoding a secreted modified form of wild type Renilla luciferase. Additionally, the polypeptides encoded by the polynucleotides of the present in... | 09/17/2002 |
| 6432709 | Encapsidation cell lines and expression vectors for transcomplementation of defective retroviral vectors The present invention relates to novel cell lines, so-called transcomplementation cell lines, which enable the packaging of recombinant retroviral RNAs carrying nucleotide sequences of interest. The present invention aims at transferring and expressing th... | 08/13/2002 |
| 6369211 | MAGE-3 peptides presented by HLA class II molecules The invention describes the HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ | 04/09/2002 |
| 6338964 | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration A cell culture medium which is low in dissolved carbon dioxide is disclosed. The medium contains less than about 1 g/L added sodium bicarbonate and includes an organic buffer and a metal complexing agent. The medium is preferably essentially free of added... | 01/15/2002 |
| 6333167 | Methods and reagents for identifying inhibitors of proteolysis of membrane-associated proteins The present disclosure provides DNA constructs, genetically modified host cells and methods for identifying inhibitors of proteolysis of membrane-associated protease substrates including, but not limited to, amyloid precursor protein, a Notch protein and ... | 12/25/2001 |
| 6312926 | mRNA capping enzymes and uses thereof The present invention provides an isolated nucleic acid encoding a mammalian capping enzyme. The present invention further provides an isolated nucleic acid encoding a mammalian (Guanine-7-) methyltransferase enzyme. The present invention also provides an... | 11/06/2001 |
| 6303331 | Vertebrate apoptosis gene: compositions and methods The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant ... | 10/16/2001 |
