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| Number | Title | Issue Date |
| 7915041 | Hybridoma capable of producing anti-dectin-1 monoclonal antibody A hybridoma capable of producing a monoclonal antibody against dectin-1, and a monoclonal antibody which specifically reacts with dectin-1. ... | 03/29/2011 |
| 7361345 | Anti-CD40 antibodies capable of blocking B-cell activation Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the... | 04/22/2008 |
| 7335508 | Porous plasma protein matrices and methods for preparation thereof The present invention relates to porous freeze-dried plasma protein matrices having an open channel structure and a concentration gradient of plasma proteins crosslinked by the action of thrombin, and methods of producing said matrices. The compositions of the prese... | 02/26/2008 |
| 7312089 | Detection of erythropoietin and erythropoietin receptor The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical ... | 12/25/2007 |
| 7309489 | Mouse CD40 ligand-specific antibodies and hybridomas There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding r... | 12/18/2007 |
| 7300763 | Method of testing myelotoxicity with the use of flow cytometer The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing smears. To this end, markers for discriminating and identifying hematop... | 11/27/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7220411 | Compositions comprising anti-CCR5 antibody This invention provides a composition for inhibiting HIV-1 infection comprising at least two compounds in synergistically effective amounts for inhibiting HIV-1 infection, wherein at least one of the compounds prevents the productive interaction between HIV-1 and an... | 05/22/2007 |
| 7217565 | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. ... | 05/15/2007 |
| 7205280 | Methods of suppressing microglial activation Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS ... | 04/17/2007 |
| 7193064 | Anti-CD40 monoclonal antibody An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. ... | 03/20/2007 |
| 7183108 | Selection and uses of lactic acid bacteria strains modulating non-specific immunity The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. The strains can also be incorporated in food supplements such as fe... | 02/27/2007 |
| 7153686 | Compositions of enriched central nervous system stem cell and progenitor cell populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. ... | 12/26/2006 |
| 7063845 | Human anti-CD40 antibodies The invention is directed to human antibodies that bind CD40 (e.g., human CD40), methods of producing the antibodies and methods of use. Invention human CD40 antibodies include antibodies that can modulate one or more activities of CD40, such as increasing or decrea... | 06/20/2006 |
| 7037719 | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. ... | 05/02/2006 |
| 7030225 | Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission of the secondary signal (costimulatory signal) essential for the activ... | 04/18/2006 |
| 7022521 | Methods and compositions for treating platelet-related disorders using MPL pathway inhibitory agents The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of circulating platelets to low or below normal levels. Methods and pharmaceutical... | 04/04/2006 |
| 6987171 | Human CD28 specific monoclonal antibodies for antigen-non-specific activation of T-lymphocytes The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all sub-groups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically.... | 01/17/2006 |
| 6972125 | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r... | 12/06/2005 |
| 6951645 | Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy A “cocktail” combination of two monoclonal antibodies respectively acting on different sites of the platelet GPIIb-IIIa complex has been disclosed. This “cocktail” combination can completely block receptor function of the GPIIb-IIIa complex, inhibit platelet... | 10/04/2005 |
| 6916628 | Method for the measurement of soluble CD14 proteins separately The present invention provides a method for qualitative determination of low molecular weight soluble CD14 proteins separately. The present invention also provides antibodies specific to high molecular weight soluble CD14 proteins. Further, the present invention pro... | 07/12/2005 |
| 6913747 | Humanized immunoglobulin reactive with B7 therewith The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune... | 07/05/2005 |
| 6875580 | Antibodies specific for plasmacytoid dendritic cells The invention provides immunological reagents (antibodies) capable of binding to plasmacytoid dendritic cells (pDC), to cell lines which express such antibodies and to a process for identifying and purifying plasmacytoid dendriticcells from tissues containing pDC us... | 04/05/2005 |
| 6849258 | LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated ... | 02/01/2005 |
| 6803039 | Human monoclonal antibody against a costimulatory signal transduction molecule AILIM Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety... | 10/12/2004 |
| 6756481 | IL-23 receptor binding compositions Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described... | 06/29/2004 |
| 6737059 | Methods of inhibiting inflammatory processes and alleviating symptoms associated with multiple sclerosis Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the multiple sclerosis disease, by adminstering to a patient a phamaceuticall... | 05/18/2004 |
| 6733980 | Diagnostic method for detection of molecular forms of eosinophilic cationic protein (ISO-ECPS) Diagnostic methods comprise measuring specifically the level of at least one iso-eosinophilic cationic protein (iso-ECP) in a sample from an individual to be diagnosed, and comparing the measured level of the iso-ECP with a predetermined level of the iso-ECP. The is... | 05/11/2004 |
| 6713249 | Cell matrix plaques of initial bone formation An isolated and essentially purified cell matrix plaque of initial bone formation comprising of αvβ3 integrin and rapid assays using such cell matrix plaques to measure potentials of factors, regimens or tissues for stimulation and/or inhibit... | 03/30/2004 |
| 6709833 | Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of... | 03/23/2004 |
| 6680176 | Identification of candidate ligands which modulate antigen presenting cells The present invention relates to the identification of candidate ligands which modulate antigen presenting cells. Specifically, ligands which superactivate antigen presenting cells are identified.... | 01/20/2004 |
| 6670123 | Method for detecting hematopoietic stem cells The present invention provides an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a purified KIAA0918 protein, ... | 12/30/2003 |
| 6627740 | Monoclonol antibody which binds to a polypeptide having pre-B cell growth supporting ability The present invention provides a monoclonal antibody which binds to a polypeptide as set forth in SEQ ID NO: 1 as described herein.... | 09/30/2003 |
| 6620915 | Monoclonal antibodies specific for integrin -d subunit The present invention relates to monoclonal antibodies immunospecific for 댝 integrin, and antibodies that compete with said antibodies for 댝 binding.... | 09/16/2003 |
| 6610483 | Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof The present invention provides a method for the identification of a pattern of changes in cellular responses induced by the selective inhibition of a signaling molecule, by determining the specific effects of a selective inhibitor on a mutant form of a si... | 08/26/2003 |
| 6605279 | Therapeutic compositions for inhibiting the interactions of B7-1 and B7-2 with their natural ligands Disclosed is a composition for inhibiting the interactions of B7-1 and B7-2 with their natural ligands. Such compositions comprise an antibody specific for B7-2 and an antibody specific for B7-1, in a pharmaceutically acceptable carrier. The composition m... | 08/12/2003 |
| 6541611 | LO-CD2b antibody A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when the immune response is mediated by the activation and pro... | 04/01/2003 |
| 6485970 | Immunointeractive antibody The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to determine the presence and levels of particular TABMs provides... | 11/26/2002 |
| 6485928 | Use of granulysin as an antimicrobial agent The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population. Of particular interest is the use of the active fragment ... | 11/26/2002 |
| 6482598 | Antibody recognizing a small subset of human hematopoietic cells The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myelo... | 11/19/2002 |
