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| Number | Title | Issue Date |
| 7332582 | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, and is capable of eliciting an anti-... | 02/19/2008 |
| 7309489 | Mouse CD40 ligand-specific antibodies and hybridomas There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding r... | 12/18/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7220411 | Compositions comprising anti-CCR5 antibody This invention provides a composition for inhibiting HIV-1 infection comprising at least two compounds in synergistically effective amounts for inhibiting HIV-1 infection, wherein at least one of the compounds prevents the productive interaction between HIV-1 and an... | 05/22/2007 |
| 7138119 | Compositions and methods for inhibition of HIV-1 infection This invention provides a composition which comprises an admixture of three compounds, wherein: (a) one compound is an antibody which binds to a CCR5 receptor; (b) one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope g... | 11/21/2006 |
| 7030225 | Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission of the secondary signal (costimulatory signal) essential for the activ... | 04/18/2006 |
| 6987171 | Human CD28 specific monoclonal antibodies for antigen-non-specific activation of T-lymphocytes The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all sub-groups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically.... | 01/17/2006 |
| 6893813 | Methods for treatment of HIV and other infections using a T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods for expandin... | 05/17/2005 |
| 6875609 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 04/05/2005 |
| 6849258 | LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated ... | 02/01/2005 |
| 6803039 | Human monoclonal antibody against a costimulatory signal transduction molecule AILIM Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety... | 10/12/2004 |
| 6790662 | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides This invention provides a method of isolating CD8+ cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8+ cells but does not activate the CD8+ cells once bound. This invention also pr... | 09/14/2004 |
| 6787354 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 09/07/2004 |
| 6737059 | Methods of inhibiting inflammatory processes and alleviating symptoms associated with multiple sclerosis Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the multiple sclerosis disease, by adminstering to a patient a phamaceuticall... | 05/18/2004 |
| 6689607 | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also p... | 02/10/2004 |
| 6685947 | T helper cell epitopes The present invention provides T helper cells epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQ... | 02/03/2004 |
| 6602503 | Recombinant anti-VLA-4 antibody molecules The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific and non-specific inflammation, including asthma and inflamma... | 08/05/2003 |
| 6596536 | Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses An isolated antibody that specifically binds a peptide coded by a nucleotide sequence coding for a variable region of chain of an human T lymphocyte receptor, said nucleotide sequence having a nucleotide sequence chosen from any of: V segme... | 07/22/2003 |
| 6541611 | LO-CD2b antibody A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when the immune response is mediated by the activation and pro... | 04/01/2003 |
| 6514758 | Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods f... | 02/04/2003 |
| 6515111 | Monoclonal antibody which inhibits transendothelial migration of human mononuclear leukocytes The present invention relates to a monoclonal antibody against human mononuclear leukocytes which is capable of inhibiting transmigration of human mononuclear leukocytes after their adhesion to vascular endothelial cells, and to a hybridoma producing this... | 02/04/2003 |
| 6511665 | Antibodies to interleukin-1 receptors The present invention provides monoclonal antibodies and binding proteins which specifically bind to the IL-1 receptor. Also provided are methods for detecting IL-1 receptors on cells, and for detecting soluble IL-1 receptors in serum.... | 01/28/2003 |
| 6498006 | Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods f... | 12/24/2002 |
| 6485970 | Immunointeractive antibody The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to determine the presence and levels of particular TABMs provides... | 11/26/2002 |
| 6482598 | Antibody recognizing a small subset of human hematopoietic cells The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myelo... | 11/19/2002 |
| 6403091 | Methods for inhibiting the rejection of a transplant organ in a subject with 5C8-specific antibodies This invention provides for a method for inhibiting rejection of a transplant organ in a subject which comprises administering to the subject an antibody capable of binding to a protein which is specifically recognized by monoclonal antibody 5c8 produced ... | 06/11/2002 |
| 6365404 | Hematopoietic cell method for treatment of HIV infection The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to "capture" virons in a sterile micro-environment. The host's CD4 T-cell lymphoc... | 04/02/2002 |
| 6365343 | Intercellular adhesion molecule powder formulation The present application discloses a finely divided, dry powdered pharmaceutical composition which is specially adapted to be administered as an insufflate which includes the following ingredients: (a) an pharmacologically effective amount of sICAM-1; (b) an am... | 04/02/2002 |
| 6352832 | Anti-CCR2 antibodies and methods of use therefor The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates ... | 03/05/2002 |
| 6331615 | Nucleic acid molecule encoding heavy or light chain of an antibody which specifically recognizes a protein specifically recognized by monoclonal antibody 5c8 (anti-CD40 ligand) The present invention provides for an isolated nucleic acid molecule encoding a light chain protein of an antibody, wherein the antibody binds specifically to a protein specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having AT... | 12/18/2001 |
| 6316257 | Modified rapid expansion methods ("modified-REM") for in vitro propagation of T lymphocytes The present invention provides a modified rapid expansion method (termed "low-PBMC-REM" or "modified-REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral... | 11/13/2001 |
| 6312692 | Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided.... | 11/06/2001 |
| 6300090 | Methods of use of viral vectors to deliver antigen to dendritic cells This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxi... | 10/09/2001 |
| 6280957 | Costimulatory blockade and mixed chimerism in allo-transplantation Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation.... | 08/28/2001 |
| 6274347 | Method of producing a cell surface bound lam-1 specific antibody A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis are disclosed. Also disclosed are methods for the specific... | 08/14/2001 |
| 6271028 | Hematopoietic cell method for treatment of HIV infection The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to "capture" virions in a sterile micro-environment. The host's CD4 T-cell lympho... | 08/07/2001 |
| 6268214 | Vectors encoding a modified low affinity nerve growth factor receptor In the course of therapy following an allogeneic bone marrow transplant (allo-BMT) in which lymphocytes were removed from the transplant, donor lymphocytes are introduced after a delay to reconstitute immunity in the patient. According to the invention, t... | 07/31/2001 |
| 6242176 | Papillomavirus cellular receptor The present invention provides methods and reagents for treating or preventing papillomavirus infection. In one aspect, the invention provides reagents and methods for attenuating the ability of papillomavirus to bind to cells by blocking access of papill... | 06/05/2001 |
| 6242579 | Antigen found on a small subset of human hematopoietic cells which binds to monoclonal antibody MG1 The subject invention pertains to an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells and binds to monoclonal antibody MG1... | 06/05/2001 |
| 6235525 | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyt... | 05/22/2001 |
