Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7972768 | Wet combustion engine This invention relates to systems, apparatus and methods of operating a wet combustion engine and apparatus therefore, capable of biologically burning fuels within a wet combustion chamber within a bioproactor system, including but not limited to, organic carbon con... | 07/05/2011 |
| 7862992 | Dynamic fermentation controller One or more set point values are generated by a dynamic fermentation controller for one or more of temperature, pH, and enzyme dosage for a fermentation system. The one or more set point values are output to one or more controllers of the fermentation system. The ge... | 01/04/2011 |
| 7585617 | Method and device for thermal conditioning of a cell The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and for quantitatively and qualitatively detecting the released ingredien... | 09/08/2009 |
| 7563565 | Method of preparing bio-identical hormones The embodied composition is a dose of bio-identical hormones in a solvent with a vasodilator, a hormone modulator, and a carrier for balancing and maintaining Cortisol level in a human. The dose comprises progesterone ranging from about 0.005 wt % to about 41 wt %; ... | 07/21/2009 |
| 7435581 | Integrated bio-reactor monitor and control system Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. The controller receives information related to a c... | 10/14/2008 |
| 7393656 | Methods and compositions for risk stratification The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and... | 07/01/2008 |
| 7381535 | Methods and compositions for detecting receptor-ligand interactions in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 06/03/2008 |
| 7354729 | High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro... | 04/08/2008 |
| 7354730 | High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc... | 04/08/2008 |
| 7320889 | Cell cultivation device and method A device and a method for the cultivation of cells is disclosed that utilizes external pneumatic pressure responsive to liquid level sensors to gently recirculate and cause turbulence in cell growth medium to promote cell growth without any shearing action and witho... | 01/22/2008 |
| 7314708 | Method and apparatus for electronic synthesis of molecular structures A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antig... | 01/01/2008 |
| 7312089 | Detection of erythropoietin and erythropoietin receptor The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical ... | 12/25/2007 |
| 7270996 | Automated bioculture and bioculture experiments system The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, ase... | 09/18/2007 |
| 7270947 | Method for controlling biooxidation reactions Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate ... | 09/18/2007 |
| RE39815 | Method for determining ion channel activity of a substance A method for determining the ion channel activity of a substance comprises the steps of (i) expressing the substance as a heterologous protein in a host cell, and (ii) determining changes in permeability of the plasma membrane of the host cell induced by expression ... | 09/04/2007 |
| 7235353 | Predicting hepatotoxicity using cell based assays Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of p... | 06/26/2007 |
| 7217505 | Method for determining whether condition is symptom of metabolic syndrome The use of cortisol agonist for preparing a system for diagnosis of the metabolic syndrome and related conditions as belly fatness, insulin resistancy including increased risk of developing senile diabetes, i.e. diabetes type II, high blood fats and high blood press... | 05/15/2007 |
| 7189527 | Bacterial oxidation of sulphide ores and concentrates A process for bacterial oxidation of sulphide ores and concentrates in which the ore or concentrate is leached with a bacterial culture containing one or more strains of both Sulfobacillus and Thermoplasma. ... | 03/13/2007 |
| 7184671 | Optical transmission controller An optical transmission controller for controlling an optical transmission system is presented. The optical transmission controller according to the present invention includes a laser controller, a modulator block controller, and a modulation driver controller. In s... | 02/27/2007 |
| 7183108 | Selection and uses of lactic acid bacteria strains modulating non-specific immunity The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. The strains can also be incorporated in food supplements such as fe... | 02/27/2007 |
| 7169599 | Fluid interface for bioprocessor systems An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an ou... | 01/30/2007 |
| 7160719 | Bioartificial liver system A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes... | 01/09/2007 |
| RE39449 | Apparatus for cryopreservation and recovery of red blood cells A system dynamically adjusts the delivery rate of a cryopreservation solution to red blood cells to permit freezing. The delivery rate is preferably determined according to an equation that maintains a linear change of red blood cell osmolarity over time so as to pr... | 12/26/2006 |
| 7141421 | Control of metabolism with human 2-oxoglutarate carrier The present invention is directed to compositions and methods related to the use of human OGC as an uncoupling protein. ... | 11/28/2006 |
| 7125658 | Small protein that interacts with a ribonucleotide reductase subunit and uses thereof The present invention provides for an isolated Sml1 protein or a homologue thereof. The present invention also provides for a screening assay for identifying compounds that are capable of reducing the division rate of a cell by altering an interaction between a ribo... | 10/24/2006 |
| 7112403 | Method for the identification of anesthetics Human and mouse TREK-1 potassium transport proteins are disclosed as well a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia a... | 09/26/2006 |
| 7101719 | Support and method for cell based assays Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different po... | 09/05/2006 |
| 7037254 | Controlled environment device The present invention relates to devices and methods for providing controlled environments for surgical procedures, as well as transplantation and wound healing. In particular, one embodiment of the present invention provides devices and methods to provide an anaero... | 05/02/2006 |
| 7026132 | Method of monitoring the effect of Cathepsin S inhibitors The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed sub... | 04/11/2006 |
| 7023547 | Apparatus including a biochip for imaging of biological samples and method Imaging apparatus which images the changes in height of reactive spots on the surface of a slide requires the surface roughness of the slide to be small enough to distinguish the changes in height from the roughness features of the slide. ... | 04/04/2006 |
| 7020560 | Methods for cell-based combinatorial logic A method for cell-based combinatorial logic includes the steps of providing at least one genetically engineered cell, the genetically engineered cell having at least one transcriptional unit. The transcriptional unit includes a gene and a promoter, wherein applicati... | 03/28/2006 |
| 7011939 | Apparatus and method for electrophysiological testing A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, Xenopus oocytes. The invention furthe... | 03/14/2006 |
| 7002670 | Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance An improved optical sensor and method for measuring concentration of a chemical constituent where measurement interference from other chemical compounds is present in the solution is provided. More specifically, the invention relates to a system for measuring the am... | 02/21/2006 |
| 6984526 | Spectrophotometric method for determining the viability of a sample containing platelets A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared wit... | 01/10/2006 |
| 6979733 | Epoxide hydrolases, nucleic acids encoding them and methods of making and using them The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are us... | 12/27/2005 |
| 6974197 | Portable glovebox and filtration system A portable containment system includes a glovebox apparatus, a self-contained filter unit, and removable conduits extending therebetween. The glovebox apparatus includes a first module for releasably covering a first sidewall opening. The first module, which has bod... | 12/13/2005 |
| 6955589 | Delivery system for magnetorheological fluid A magnetorheological fluid delivery system includes a mixing and tempering vessel. Fluid is admitted to the vessel via a plurality of tangential ports, creating a mixing of the fluid in the vessel and promoting homogeneity. Fluid may be reconstituted in the vessel b... | 10/18/2005 |
| 6942650 | Evacuator An improved smoke evacuation system (10), a method for removing gaseous byproducts of surgical procedures, and noxious vapors from chemicals, is provided. The smoke, and vapor evacuation system includes a vacuum head (18) positioned at a surgical site ... | 09/13/2005 |
| 6942963 | Methods for identifying treatments for neurotoxicity in Alzheimer's disease caused by β-amyloid peptides The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includ... | 09/13/2005 |
| 6942962 | Computer monitoring and control of fermentation It is desirable to enhance reproducibility and control of batch fermentation processes. Some examples of these processes include: alcoholic beverage manufacture, and acetone and pharmaceutical production. A cellular yield curve defines the relationship between subst... | 09/13/2005 |
