Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7642089 | Immunosubtraction method Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminat... | 01/05/2010 |
| 7449329 | Blood test kit A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to permeate through, while agglutinated red blood cells cannot. The apparatus a... | 11/11/2008 |
| 7396674 | Reaction vessel Reaction vessel 1 for assaying of a subject substrate molecule comprises a translucent narrow tube 2 which has a liquid feed port 4 at one end, and which is intended to be packed with microparticles 5 as solid phase support on which a rea... | 07/08/2008 |
| 7368282 | Process and device for determining the activity of enzymes in liquids, or the concentration and/or activity of inhibitors in liquids A process and device are disclosed to determine the activity of enzymes in liquids in a largely automatic manner. The device for carrying out this process has a column (1) with a chromatographic carrier for treating a measurement sample. The carrier is mixed ... | 05/06/2008 |
| 7364899 | Device for monitoring haptotaxis The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including b... | 04/29/2008 |
| 7358486 | Cleaning and reconditioning of an inline automated chemical analysis system A method, system, and mixture for simultaneously cleaning and reconditioning at least a part of a sampling pathway of an inline automated mass spectrometry system are disclosed. A sampling pathway including a probe or a nebulizer, in one example, may be simultaneous... | 04/15/2008 |
| 7326561 | Flow-thru chip cartridge, chip holder, system and method thereof A system for performing hybridization assays comprises a cartridge for housing a flow through device, where the cartridge includes a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and a fluid... | 02/05/2008 |
| 7323140 | Moving microdroplets in a microfluidic device The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms ... | 01/29/2008 |
| 7320862 | Microfluidic extraction method The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier. ... | 01/22/2008 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7274447 | Material porosity pressure impulse testing system A system and method for determining porosity of a material enables rapid testing of materials by detecting test particle penetration. The material is held by a test chamber wherein a test particle solution covers a surface of the material. The test chamber is pressu... | 09/25/2007 |
| 7261812 | Multi-column separation devices and methods Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types ma... | 08/28/2007 |
| 7217562 | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluid... | 05/15/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7192784 | Method of measurement in chromatography A substantial amount of a marker reagent associated with a measurement is measured in a marker reagent measurement area, and the substantial amount of the marker reagent is reflected by a result obtained in a reaction result measurement area where a reaction with a ... | 03/20/2007 |
| 7166443 | Methods, compositions, and automated systems for separating rare cells from fluid samples The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly a... | 01/23/2007 |
| 7166459 | Test device and method of making same The present invention discloses a test device including a support member; a top member mounted to the support member, wherein in the support member and the top member are configured such that they together define a discrete chamber. The discrete chamber includes a f... | 01/23/2007 |
| RE39457 | Liquid specimen container and attachable testing modules A biological fluid collection container comprising a cup member, a lid assembly removably mounted to the cup member comprising a housing with a downwardly extending cylindrical skirt, a luer lock with a throughgoing bore extending from one side of the lid housing. A... | 01/02/2007 |
| 7128876 | Microdevice and method for component separation in a fluid The present invention relates to a microdevice for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, and, in combination with a microchannel formed in the first surface, defines a separation conduit for sep... | 10/31/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7105339 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/12/2006 |
| 7074327 | Sample preparation for parallel chromatography Systems and methods are provided for preparing samples for chromatographic separations and then chromatographically separating the prepared samples, preferably in a high-throughput fashion utilizing multiple parallel first (fluid) processing regions in fluid communi... | 07/11/2006 |
| 7070988 | Oligosaccharide synthesizer After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an... | 07/04/2006 |
| 7069151 | Mapping of differential display of proteins The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of ... | 06/27/2006 |
| 7049558 | Apparatus and method for heating microfluidic volumes and moving fluids A device and method for the temperature control, concentration, volume measurement and transport of microfluidic volumes are provided. The device includes one or more heating elements having a resistive material that varies with temperature. The heating elements are... | 05/23/2006 |
| 7028536 | Sealing interface for microfluidic device A threadless interface for a fluidic system includes a microfluidic device having an outer surface and an internal near-surface channel having a first width and disposed at a first depth relative to the outer surface, with the first width being less than about two t... | 04/18/2006 |
| 7022516 | Well unit for detecting cell chemotaxis and separating chemotactic cells The present invention aims at providing a well unit to be used in fabricating an apparatus whereby movements of cells based on their own actions can be accurately and easily detected, in detecting the chemotaxis of cells due to a chemotactic factor or the inhibition... | 04/04/2006 |
| 7011970 | Automatic bio-manipulation factory system for manipulating a single cell This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of cells, controls the rotation-orientation of the extracted cell automat... | 03/14/2006 |
| 6977172 | Method and apparatus for targeting localized electroporation The invention comprises an apparatus and a method of effecting localized electroporation in a relatively small target area and for introducing foreign matter into cellular material in which the target area is located. The cellular material may be in vitro, in ovo or... | 12/20/2005 |
| 6953686 | Methods of DNA purification and purified DNA The present invention provides methods for the purification of plasmid DNA that includes removal of host cell impurities, such as endotoxins, RNA, proteins, and chromosomal DNA, from an aqueous solution containing plasmid DNA and methods for separation and purificat... | 10/11/2005 |
| 6949376 | Nucleic acid amplification reaction station for disposable test devices An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber eithe... | 09/27/2005 |
| 6949355 | Methods, compositions, and automated systems for separating rare cells from fluid samples The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly a... | 09/27/2005 |
| 6932940 | Optical detection in bio-separation device using axial radiation input In a bio-separation system, incident radiation (e.g., from a laser or LED source) for detection of separated analytes is directed at the detection zone axially along the separation medium, instead of through the boundary walls of the detection zone. In one embodimen... | 08/23/2005 |
| 6929779 | Optical detection in bio-separation device using axial radiation output In a bio-separation system, emitted radiation signals representative of sample analytes are collected from the detection zone axially along the separation medium, instead of through the boundary walls of the detection zone or the separation column. In one embodiment... | 08/16/2005 |
| 6924151 | Stable factor VIII/vWF-complex There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex. ... | 08/02/2005 |
| 6923907 | Separation column devices and fabrication methods Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits... | 08/02/2005 |
| 6893879 | Method for separating analyte from a sample An analyte is separated from a fluid sample by introducing the sample into a cartridge having an extraction chamber containing capture material for capturing the analyte. The sample is forced to flow through the extraction chamber to capture the analyte with the cap... | 05/17/2005 |
| 6887693 | Device and method for lysing cells, spores, or microorganisms A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase in the lysing chamber for capturing the sample components to be lysed... | 05/03/2005 |
| 6878540 | Device for lysing cells, spores, or microorganisms A device for use with an ultrasonic transducer to lyse components of a fluid sample comprises a cartridge having a lysing chamber, an inlet port in fluid communication with the lysing chamber, and an outlet port for exit of the sample from the lysing chamber. The in... | 04/12/2005 |
| 6833238 | Petal-array support for use with microplates Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that pro... | 12/21/2004 |
