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| Number | Title | Issue Date |
| 8163537 | Nested permeable support device and method for using the nested permeable support device A nested permeable support device is described herein that can be used to perform various experiments to test new therapeutic compounds (new chemical entities). In one application, the nested permeable support device is used to perform a first pass assay to determin... | 04/24/2012 |
| 8080411 | Shallow multi-well plastic chip for thermal multiplexing Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip ... | 12/20/2011 |
| 8080410 | Centrifugal device and method for performing binding assays The invention relates to a device for performing binding assays. In particular, the invention relates to a centrifugal device for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic ... | 12/20/2011 |
| 8007745 | Anti-clogging device and method for in-gel digestion applications An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method o... | 08/30/2011 |
| 7998432 | Multidisciplinary automatic analyzer for in vitro diagnosis The device comprises reaction unit cuvettes (22) for different types of tests, a vertical axis rotor (7) which is associated with a rotation drive means and provided with a horizontal gear-teeth crown (8) delimiting radially outwardly open cavit... | 08/16/2011 |
| 7985579 | Specimen culturing assembly suitable for use in in-vitro fertilization and in other cell culturing procedures An assembly is disclosed that is to be used for the culturing of specimens such as embryos and gametes for use in in vitro fertilization. The assembly includes an annular ring which is affixed to the stage of an optical viewing instrument, such as a microscope. The ... | 07/26/2011 |
| 7943100 | Cuvette for in vitro diagnosis The device comprises reaction unit cuvettes for different types of tests, a vertical axis rotor which is associated with a rotation drive means and provided with a horizontal gear-teeth crown delimiting radially outwardly open cavities for receiving the reaction uni... | 05/17/2011 |
| 7927867 | Device for evaluating in vitro cell migration under flow conditions, and methods of use thereof The current invention is directed towards a device that useful for studying cell migration. It is preferred that the device is configured to study stem cell, particularly hematopoetic stem/precursor cell homing. The device allows for detailed analysis of the various... | 04/19/2011 |
| 7858365 | Sample block apparatus and method for maintaining a microcard on a sample block A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a micr... | 12/28/2010 |
| 7851208 | Optical reader system and method for monitoring and correcting lateral and angular misaligments of label independent biosensors An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In... | 12/14/2010 |
| 7842499 | Substrates, devices, and methods for cellular assays The present invention relates to the field of molecular diagnostics. In particular, the present invention provided improved substrates and methods of using liquid crystals and other biophotonically based assays for quantitating the amount of an analyte in a sample. ... | 11/30/2010 |
| 7700347 | Methods and apparatuses for conducting assays in animals The invention provides apparatuses, systems, and methods for conducting assays in aquatic animals. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate morphological, anatomical, or behavioral cha... | 04/20/2010 |
| 7695954 | Micropatterned plate with micro-pallets for addressable biochemical analysis A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some ... | 04/13/2010 |
| 7642088 | Device for susceptibility testing of bacterial pathogens and vaccine strains in poultry Device for susceptibility testing of bacterial pathogens and vaccine strains in poultry with a microtiter plate comprising a plurality of wells and at least one well with a coating containing an antibiotic of a marker of a vaccine strain for the vaccination of poult... | 01/05/2010 |
| 7582472 | Apparatus and method for liquid sample testing There is provided a device for partitioning a liquefied sample into discrete volumes. The device includes a bottom member; a top member disposed adjacent the bottom member; and at least one channel member disposed between the top and bottom members. The at least one... | 09/01/2009 |
| 7560272 | Specimen collection and assay container The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows thr... | 07/14/2009 |
| 7534600 | Rapid bacterial quantification The invention provides devices and methods for rapid quantification of microorganisms and cells. In one embodiment, the devices comprise a container having an upper compartment and a lower compartment, wherein the upper compartment is connected to a passage through ... | 05/19/2009 |
| 7501278 | Extracellular potential measuring device and method for fabricating the same A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of th... | 03/10/2009 |
| 7452712 | Sample block apparatus and method of maintaining a microcard on a sample block A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a micr... | 11/18/2008 |
| 7442542 | Shallow multi-well plastic chip for thermal multiplexing Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip ... | 10/28/2008 |
| 7439056 | Peelable and resealable devices for arraying materials Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the f... | 10/21/2008 |
| 7438856 | Microfluidic devices and methods Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in... | 10/21/2008 |
| 7435578 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 10/14/2008 |
| 7432511 | Method of operating liquid in the vacuum or low-pressure environment and observing the operation and device for the operation and observation A method of operating liquid in a vacuum or low-pressure environment and observing the operation and a device for the operation and the observation respectively, including the steps of preparing a housing, putting the housing in the vacuum or low-pressure environmen... | 10/07/2008 |
| 7429492 | Multiwell plates with integrated biosensors and membranes The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane. ... | 09/30/2008 |
| 7429479 | Inverted orientation for a microplate A method of conducting amplification comprising loading a liquid polynucleotide sample into a well of a microplate and covering the well of the microplate with a cover, such that the cover fluidly seals the liquid polynucleotide sample within the well. The method th... | 09/30/2008 |
| 7429316 | Planar patch-clamp cartridge with integrated electrode A planar patch-clamp cartridge includes a common ground electrode through a conductive medium reaching into each extracellular chamber. The cartridge is first primed with intracellular solution injected from dispensing tips inserted from above into the intracellular... | 09/30/2008 |
| 7427512 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on t... | 09/23/2008 |
| 7425712 | Method of operating liquid in the vacuum or low-pressure environment and observing the operation and device for the operation and observation A method of operating liquid in a vacuum or low-pressure environment and observing the operation and a device for the operation and the observation respectively, including the steps of preparing a housing, putting the housing in the vacuum or low-pressure environmen... | 09/16/2008 |
| 7419823 | Device and method for monitoring leukocyte migration A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. Th... | 09/02/2008 |
| 7410804 | Process of parallel sample presentation A process of forming an array of powder samples arranged in predefined locations where all samples have a flat surface in a common plane has been developed. A main support having at least N perforations from a first surface of the main support through a second surfa... | 08/12/2008 |
| 7410616 | Device for the controlled exposure of reservoir-based sensors Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reserv... | 08/12/2008 |
| 7407815 | Liquid crystal cassette A functional cassette for the detection of ligands comprises a first inner housing, a second middle housing and a third outer housing and each housing is at least partially rotatable relative to an adjoining housing. The first inner housing contains a central well a... | 08/05/2008 |
| 7399628 | Body for flow-through cells and the use thereof A system of flow-through cells is obtained by assembling a body with a base plate. The body has a first spring element and a first stop, disposed on opposite end sections of the body, at least one second spring element and a corresponding second stop, disposed on op... | 07/15/2008 |
| 7396677 | Method of preparing nucleic acids for detection A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit con... | 07/08/2008 |
| 7396674 | Reaction vessel Reaction vessel 1 for assaying of a subject substrate molecule comprises a translucent narrow tube 2 which has a liquid feed port 4 at one end, and which is intended to be packed with microparticles 5 as solid phase support on which a rea... | 07/08/2008 |
| 7390463 | Microcolumn-based, high-throughput microfluidic device A biological assay device for use in molecular biology, pharmaceutical research, genomic analysis, combinatorial chemistry, and in the general field of the analysis of molecules that may be deposited on supports of various kinds is provided. Specifically, the presen... | 06/24/2008 |
| 7390676 | System and method for programmable illumination pattern generation A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on t... | 06/24/2008 |
| 7390648 | Microelectromechanical devices useful for manipulating cells or embryos, kits thereof, method of making same, and methods of use thereof The present invention relates generally to microelectromechanical systems (MEMS) devices for the manipulation of cells or groups of cells, such as oocytes, embryos, and sperm. In particular, the present invention relates to Cell Labeling MEMS devices (2F), Mi... | 06/24/2008 |
| 7387891 | Optical instrument including excitation source An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to... | 06/17/2008 |
