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| Number | Title | Issue Date |
| 7312070 | β-catenin oligonucleotide microchip and method for detecting β-catenin mutations employing same The present invention relates to a β-catenin oligonucleotide microchip for detecting mutation in the mutational hot spot regions of β-catenin gene, a manufacturing process thereof and a method for detecting the β-catenin mutation employing same, wherein specific ... | 12/25/2007 |
| 7312089 | Detection of erythropoietin and erythropoietin receptor The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical ... | 12/25/2007 |
| 7312090 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 12/25/2007 |
| 7311880 | Well-less filtration device The present invention provides a well-less filtration device that includes a pre-filter layer; a support layer; and at least one layer of solid phase extraction medium disposed between the pre-filter layer and the support layer. At least a portion of the pre-filter ... | 12/25/2007 |
| 7312032 | Methods for screening ligands that activate the translocation of a steroid receptor to the nucleus in mammalian cells The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that... | 12/25/2007 |
| 7312035 | Methods of genetic analysis of yeast Arrays of oligonucleotide probes which are complementary to a plurality of S. cerevisisae and S. pombe genes are disclosed. The arrays may be used to measure the expression levels of a plurality of genes simultaneously. ... | 12/25/2007 |
| 7312068 | Capillary pins for high-efficiency microarray printing device This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention... | 12/25/2007 |
| 7312069 | Method of analyzing ligand in sample and apparatus for analyzing ligand in sample A sample analyzing method capable of high-precision analysis without being affected by vibration and optical design is provided. In the sample analyzing method, a sample containing a ligand is caused to bind to a receptor that can bind specifically to the ligand, an... | 12/25/2007 |
| 7309614 | Self-referencing biodetection method and patterned bioassays The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical ... | 12/18/2007 |
| 7308913 | Liquid filling method, liquid filling apparatus, and discharge apparatus A liquid filling apparatus includes a discharge head having a cavity for storing liquid, a nozzle communicated with the cavity, and a discharge device for discharging liquid stored in the cavity through the nozzle. In addition, the apparatus includes a liquid supply... | 12/18/2007 |
| 7306941 | Biochemical measuring chip and measuring apparatus A simple and convenient sensor and measuring apparatus utilizing the optical interference effect of an optical thin film capable of measuring the binding between biochemical substances at a high throughput and having alkali resistance. An optical thin film of silico... | 12/11/2007 |
| 7306924 | Biosensor and related method A method for collecting a microbiological substance utilizes a micro fabricated biochip having a collection chamber. A fluid sample containing a microbiological entity of interest is delivered to the collection chamber in the biochip. Then a non-uniform electric fie... | 12/11/2007 |
| 7303875 | Nano-chem-FET based biosensors Methods of detecting components of interest, e.g., nucleic acids and sugars, are provided. The methods comprise contacting one or more nanowires comprising a functional group with a sample containing the component or components of interest. In one embodiment, the fu... | 12/04/2007 |
| 7303874 | Discrimination of from closely related microorganisms by analysis of 16S and 23S rRNA with oligonucleotide microchips The present invention relates to methods and compositions for using nucleotide sequence variations of 16S and 23S rRNA within the B. cereus group to discriminate a highly infectious bacterium B. anthracis from closely related microorganisms. Sequence v... | 12/04/2007 |
| 7300756 | Epoxide polymer surfaces Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can ... | 11/27/2007 |
| 7300788 | Method for genotyping polymorphisms in humans The invention provides nucleic acid sequences that are complementary, in one embodiment, to a wide variety of human polymorphisms. The invention provides the sequences in such a way as to make them available for a variety of analyses including genotyping a large num... | 11/27/2007 |
| 7300803 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 11/27/2007 |
| 7300631 | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the... | 11/27/2007 |
| 7301015 | Genotyping kit for diagnosis of human papilloma virus infection The present invention relates to a genotyping kit for diagnosis of detecting the human papillomavirus (HPV) infection, probes for genotyping the HPV, and DNA chips including the probes. Also, the present invention relates to a method for diagnosis of HPV infection. | 11/27/2007 |
| 7300633 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 11/27/2007 |
| 7301628 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 11/27/2007 |
| 7301642 | Apparatus and method of assay in utilizing attenuated total reflection A surface plasmon resonance (SPR) assay apparatus is loaded with a sensor unit. The sensor unit has a sensing surface and a flow channel, which has an entrance end opening and an exit end opening, and causes analyte fluid introduced through the entrance end opening ... | 11/27/2007 |
| 7297515 | Zinc finger proteins Novel zinc finger proteins and nucleic acids encoding the proteins are provided. The zinc finger proteins interact with ZNF202, a zinc finger protein that regulates the expression of a variety of genes involved in lipid metabolism and transportation. Modulation of t... | 11/20/2007 |
| 7297500 | Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 11/20/2007 |
| 7297502 | Devices and methods for analyte assays with built-in result reporting using recognizable symbols The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample. The invention provides devices having a positive control area covered with an opaque, movable material, such as an ink, dye, or other material, that... | 11/20/2007 |
| 7294502 | Device for collecting liquid samples The invention relates to a device for collecting samples of fluids, in particular of body fluids such as saliva, said device comprising an absorbent pad and two housing parts which are connected to the latter in a movable manner and can enclose the absorbent pad. Th... | 11/13/2007 |
| 7295316 | Fluorescent detector with automatic changing filters A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices. ... | 11/13/2007 |
| 7293459 | Image-based sensing of acceleration A system includes a support, a pendular element, an elastic restraint, an image sensor, and a processing system. The elastic restraint couples the pendular element to the support and applies to the pendular element a restraining force that opposes movement of the pe... | 11/13/2007 |
| 7293411 | Energy scavengers which adjust their frequency by altering liquid distributions on a beam A selectively configurable beam and systems utilizing such are disclosed. The distribution of mass of the beam can be selectively adjusted or altered by adjusting one or more characteristics of the beam. Specific strategies utilizing continuous electro-wetting, and ... | 11/13/2007 |
| 7294478 | Microarray reaction cartridge An apparatus and method are provided for shipping, storing, and high-throughput processing of microarrays. An exemplary microarray cartridge according to the present invention includes a body having a cavity defined by an outer surface and two dimple features in flu... | 11/13/2007 |
| 7291504 | Assay involving detection and identification with encoded particles A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the ... | 11/06/2007 |
| 7292333 | Optical interrogation system and method for 2-D sensor arrays An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (e.g., grating coupled waveguide sensors) located in a 2D specimen plate (e.g., microplate). ... | 11/06/2007 |
| 7291471 | Cleavable oligonucleotide arrays Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described. ... | 11/06/2007 |
| 7292336 | Method and instrument for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of... | 11/06/2007 |
| 7291497 | Medical device for analyte monitoring and drug delivery The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and i... | 11/06/2007 |
| 7292742 | Waveguides for performing enzymatic reactions The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic en... | 11/06/2007 |
| 7292758 | Optoelectronic fiber photodetector The invention provides an optical fiber photodetector including a photoconductive element, such as a semiconducting element, having a fiber length. The semiconducting element is characterized as a non-composite material in at least one fiber direction. At least one ... | 11/06/2007 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7291496 | Ultrasensitive biochemical sensor An electronic sensor is provided for detecting the presence of one or more analytes of interest in a sample. The sensor preferably comprises a field effect transistor in which conductance is enhanced by analyte binding to receptors in the active region. An array of ... | 11/06/2007 |
| 7288371 | Discrimination of from closely related microorganisms by analysis of 16S and 23S rRNA with oligonucleotide microchips The present invention is directed to a novel method of discriminating a highly infectious bacterium Bacillus anthracis from a group of closely related microorganisms. Sequence variations in the 16S and 23S rRNA of the B. cereus subgroup including B.... | 10/30/2007 |
